Icazole Pregnancy

• Pregnancy of Icazole in details
• Icazole breastfeeding
• Icazole reviews

Pregnancy of Icazole in details

Congenital abnormalities (eg, skeletal, genitourinary tract, cardiovascular and ophthalmic malformations, chromosomal abnormalities, and multiple malformations) have been reported during postmarketing surveillance; however, a causal relationship has not been established.

Icazole is contraindicated for the treatment of onychomycosis during pregnancy. Although Icazole is approved for the treatment of various fungal infections, when treatment of a systemic fungal infection is needed in pregnant females, Icazole should be avoided, especially during the first trimester (Chapman 2008; Galgiani 2016; HHS [OI adult 2017]; Pappas 2016; Perfect 2010; Wheat 2007).

Icazole breastfeeding

Alternate therapy may be preferred. A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Expected benefits of therapy should outweigh the potential risk of nursing; breastfeeding is not recommended if there is doubt. Excreted into human milk: Yes (small amount) Comments: The effects in the nursing infant are unknown.

Exposure to this drug in the nursing infant has been calculated at about 450 times lower than in the mother. It has been estimated through data in the literature that fully breastfed infants (aged 3 to 12 months) would receive 1.48% of the mother's weight-adjusted dose and reach a plasma level of 0.77% of the mother's plasma level.

See references

References for pregnancy information

1. BarOz B, Moretti ME, Bishai R, Mareels G, VanTittelboom T, Verspeelt J, Koren G "Pregnancy outcome after in utero exposure to Icazole: A prospective cohort study." Am J Obstet Gynecol 183 (2000): 617-20
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Sporanox oral solution (Icazole)." Janssen Pharmaceutica, Titusville, NJ.
5. "Product Information. Sporanox (Icazole)." Janssen Pharmaceutica, Titusville, NJ.
6. "Product Information. Sporanox injection (Icazole)" Ortho Biotech Inc, Raritan, NJ.

References for breastfeeding information

1. "Product Information. Sporanox oral solution (Icazole)." Janssen Pharmaceutica, Titusville, NJ.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. Sporanox injection (Icazole)" Ortho Biotech Inc, Raritan, NJ.
5. "Product Information. Sporanox (Icazole)." Janssen Pharmaceutica, Titusville, NJ.
6. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

References

1. DailyMed. "ITRACONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Itraconazole (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. Human Metabolome Database (HMDB). "Itraconazole: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology