What happens if I overdose Iron?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry stools; blood or streaks of blood in the stool; bluish skin or nails; changes in the amount of urine produced; chest pain; coma; dizziness; dry mouth or eyes; fainting; fast or difficult breathing; fast or irregular heartbeat; flushing; increased thirst or hunger; seizures; severe nausea, vomiting, diarrhea, or stomach pain; severe or unusual tiredness or drowsiness; shortness of breath; sluggishness; unusually pale skin; vomit that looks like blood or coffee grounds.
Proper storage of Iron suspension:
Store Iron suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Iron suspension out of the reach of children and away from pets.
Overdose of Iron in details
Overdose with Feridex I.V. (ferumoxides injectable solution) has not been reported. Acute toxicity is apt to be related to Iron overload, acute back pain and allergic events. Chronic administration of therapeutic Iron in excess of the total amount of Iron needed for Iron stores may lead to hemosiderosis.
A study of (59Fe) complexed Iron-dextran utilizing isotonic saline in a 4-hour in vitro dialysis run indicated that less than 0.5% of the injected radio labeled Iron traversed the dialysis membrane. Feridex I.V. contains Iron associated with dextran. Whether Feridex I.V. (ferumoxides injectable solution) is dialyzable is not known.
What should I avoid while taking Iron?
Avoid taking carbonyl Iron within 2 hours before or 2 hours after you take other medicines. Carbonyl Iron can make it harder for your body to absorb other medicines.
Iron warnings
As with all Iron preparations, a dark colouration of the stool may occur which is without clinical significance.
PREGNANCY AND LACTATION Reproduction studies in animals did not show any foetal risk. Controlled studies in pregnant women after the first trimester have not shown any undesirable effects on mother and neonates. There is no evidence of a risk during the first trimester and the possibility of a negative influence to the foetus is unlikely to occur. Mother’s milk contains Iron bound to lactoferrin. It is not known how much Iron from the complex is passed into mother’s milk. The administration of Iron¨ is unlikely to cause undesirable effects to the nursed child.
What should I discuss with my healthcare provider before taking Iron?
Some medical conditions may interact with Iron suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have stomach or bowel problems (eg, colitis, Crohn disease, diverticulitis, ulcers)
- if you have hemolytic anemia, pernicious anemia, or other types of anemia, or if you have a condition that may cause anemia (eg, sickle cell disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency)
- if you have blood problems (eg, porphyria, thalassemia) or you have had multiple blood transfusions
Some MEDICINES MAY INTERACT with Iron suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Doxycycline, mycophenolate, penicillamine, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Iron suspension
This may not be a complete list of all interactions that may occur. Ask your health care provider if Iron suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Iron precautions
The Hemoccult Test (selective for Hb) for the proof of occulted blood is not affected accordingly, the Iron therapy does not need to be discontinued when testing for occulted blood.
Chewable Tablet: Iron overload of the organism (haemochromatose, chronic haemolysis), Iron utilisation disorders (lead anaemia, sidero-achrestic anaemia), thalassaemia, megaloblastic anaemia resulting from vitamin B12 deficiency.
In cases of infection- and tumour-associated anaemia, the substituted Iron is deposited in the RES. Iron mobilisation and utilisation will not take place until the primary cause has been relieved.
Anaemia due to infection or malignancy. Do not impact the daily insulin management of diabetes patient (0.03 bread unit per chewable tablet).
What happens if I miss a dose of Iron?
Take the missed dose as soon as you remember. However, if it is almost time to take next dose, skip the dose you missed and take the next regularly scheduled dose as directed. Do not take a double dose.
References
- DrugBank. "Iron". http://www.drugbank.ca/drugs/DB01592 (accessed September 17, 2018).
- MeSH. "Trace Elements". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- EPA Chemicals under the TSCA. "Iron: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
