What are the possible side effects of Isosorbide Dinitrate?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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a light-headed feeling, like you might pass out;
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worsening angina pain;
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fast or slow heart rate; or
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pounding heartbeats or fluttering in your chest.
Isosorbide Dinitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use Isosorbide Dinitrate. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication.
Common side effects may be more likely to occur, such as:
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headache; or
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flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Isosorbide Dinitrate in details
Applies to Isosorbide Dinitrate: capsule extended release, tablet, tablet chewable, tablet extended release
In addition to its needed effects, some unwanted effects may be caused by Isosorbide Dinitrate (the active ingredient contained in Isosorbide Dinitrate). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Isosorbide Dinitrate:
Rare
- Bluish-colored lips, fingernails, or palms
- dark urine
- difficulty with breathing
- dizziness or lightheadedness
- fever
- headache
- pale skin
- rapid heart rate
- sore throat
- unusual bleeding or bruising
- unusual tiredness or weakness
- Arm, back, or jaw pain
- blurred vision
- chest pain or discomfort
- chest tightness or heaviness
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fainting
- fast or irregular heartbeat
- sweating
If any of the following symptoms of overdose occur while taking Isosorbide Dinitrate, get emergency help immediately:
Symptoms of overdose:
- Blurred or loss of vision
- bulging soft spot on the head of an infant
- change in consciousness
- change in the ability to see colors, especially blue or yellow
- cold, clammy skin
- convulsions
- disturbed color perception
- double vision
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of constant movement of self or surroundings
- halos around lights
- headache, severe and throbbing
- increased sweating
- loss of appetite
- loss of consciousness
- nausea
- night blindness
- overbright appearance of lights
- paralysis
- sensation of spinning
- slow heartbeat
- tunnel vision
- vomiting
What is the most important information I should know about Isosorbide Dinitrate?
- Isosorbide Dinitrate extended-release may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Isosorbide Dinitrate extended-release with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Isosorbide Dinitrate extended-release may cause dizziness or light-headedness; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Check with your doctor before you drink alcohol while you are taking Isosorbide Dinitrate extended-release. Drinking alcohol may increase the risk of low blood pressure with Isosorbide Dinitrate extended-release.
- Isosorbide Dinitrate extended-release may give you daily headaches. This should become less noticeable with time. Do not change how you use Isosorbide Dinitrate extended-release to avoid these headaches. Talk with your doctor for ways to lessen this side effect.
- Isosorbide Dinitrate extended-release should not be used to stop an attack of angina; it is intended only for prevention of an attack.
- Isosorbide Dinitrate extended-release may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Isosorbide Dinitrate extended-release.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Isosorbide Dinitrate extended-release while you are pregnant. It is not known if Isosorbide Dinitrate extended-release is found in breast milk. If you are or will be breast-feeding while you use Isosorbide Dinitrate extended-release, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high doses, Isosorbide Dinitrate extended-release may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Isosorbide Dinitrate extended-release stops working well. Do not take more than prescribed. Some people who use Isosorbide Dinitrate extended-release for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as physical DEPENDENCE. If you stop taking Isosorbide Dinitrate extended-release suddenly, you may have WITHDRAWAL symptoms. These may include rapid heartbeat, chest pain, and even heart attack.
Isosorbide Dinitrate contraindications
Do not use Isosorbide Dinitrate if you are taking sildenafil (Viagra). Serious, life-threatening side effects can occur if you take Isosorbide Dinitrate while you are using sildenafil.
You should not use this medication if you are allergic to Isosorbide Dinitrate, isosorbide mononitrate (Imdur, ISMO, Monoket), or nitroglycerin, or if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling).
Before taking Isosorbide Dinitrate, tell your doctor if you have congestive heart failure, low blood pressure, or kidney disease.
Isosorbide Dinitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medication. Do not stop taking Isosorbide Dinitrate. Ask your doctor before using any headache pain medication.
Only the sublingual tablet should be used to treat an angina attack that has already begun.
Isosorbide Dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack.
It is important to keep taking this medicine as directed to prevent an angina attack. Get your prescription refilled before you run out of medicine completely.
Do not stop taking Isosorbide Dinitrate suddenly. Stopping suddenly could cause a severe angina attack.
References
- DailyMed. "ISOSORBIDE DINITRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DTP/NCI. "ISOSORBIDE DINITRATE: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Isosorbide dinitrate: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Isosorbide Dinitrate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Isosorbide Dinitrate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology
