Actions of Jenacain in details
Jenacain acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Jenacain has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Jenacain pharmacology
Jenacain stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia. Jenacain lacks surface anesthetic activity. The onset of action is rapid (2 to 5 minutes) and the duration of action is relatively short (average 1 to 1½ hours), depending upon the anesthetic technique, the type of block, the concentration, and the individual patient.
Jenacain is readily absorbed following parenteral administration and is rapidly hydrolyzed by plasma cholinesterase to aminobenzoic acid and diethylaminoethanol.
A vasoconstrictor may be added to the solution of Jenacain to promote local hemostasis, delay systemic absorption, and increase duration of anesthesia.
References
- NCIt. "Procaine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Procaine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Jenacain are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Jenacain. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
