Ketoprofen CF Pregnancy

• Pregnancy of Ketoprofen CF in details
• Ketoprofen CF breastfeeding
• Ketoprofen CF reviews

Pregnancy of Ketoprofen CF in details

Ketoprofen CF has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of embryotoxicity or teratogenicity except at doses which produced significant maternal toxicity. There are no controlled data in human pregnancy. When used late in pregnancy, it may cause premature closure of the ductus arteriosus and prolong labor and delivery. Ketoprofen CF is only recommended for use during pregnancy when benefit outweighs risk. Ketoprofen CF should be avoided near term.

See references

Ketoprofen CF breastfeeding

There are no data on the excretion of Ketoprofen CF into human milk. The manufacturer recommends that due to the adverse reaction of prostaglandin-inhibiting drugs on neonates, use in nursing women should be avoided.

See references

References for pregnancy information

1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
2. "Product Information. Orudis (Ketoprofen CF)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
3. Ostensen M "Optimisation of antirheumatic drug treatment in pregnancy." Clin Pharmacokinet 27 (1994): 486-503

References for breastfeeding information

1. "Product Information. Orudis (Ketoprofen CF)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

References

1. DailyMed. "KETOPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Ketoprofen (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. Human Metabolome Database (HMDB). "Ketoprofen: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology