Actions of Ketoprofen MR in details
Ketoprofen MR SR AA Pharma is a NSAID, propionic acid derivative. This medication has analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A pronounced analgesic effect of Ketoprofen MR is due to two mechanisms: peripheral (indirect, via inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the influence on the biological activity of other neurotrophic substances that play a key role in the release of neurotransmitters in the spinal pain brain). In addition, this drug has anti-bradykinin activity, stabilizes lysosomal membranes, causes a significant inhibition of neutrophils in patients with rheumatoid arthritis.
How should I take Ketoprofen MR?
For safe and effective use of Ketoprofen MR, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of Ketoprofen MR may increase the chance of unwanted effects, especially in elderly patients.
When used for severe or continuing arthritis, Ketoprofen MR must be taken regularly as ordered by your doctor in order for it to help you. Ketoprofen MR usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of Ketoprofen MR.
To lessen stomach upset, you may take Ketoprofen MR with food, milk, or antacid unless your doctor tells you otherwise.
Dosing
The dose of Ketoprofen MR will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Ketoprofen MR. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For osteoarthritis and rheumatoid arthritis:
- Adults—At first, 75 milligrams (mg) three times a day or 50 mg four times a day. Your doctor may increase your dose, if necessary, up to a total of 300 mg a day.
- Children—Use and dose must be determined by your doctor.
- For mild to moderate pain or menstrual cramps:
- Adults—25 to 50 mg every six to eight hours as needed. Some people may need to take as much as 75 mg every six to eight hours. Doses larger than 75 mg are not likely to give better relief.
- Children—Use and dose must be determined by your doctor.
- For osteoarthritis and rheumatoid arthritis:
- For oral dosage form (extended-release capsules):
- For osteoarthritis and rheumatoid arthritis:
- Adults—200 mg once a day, in the morning or evening. Take the medicine at the same time every day.
- Children—Use and dose must be determined by your doctor.
- For osteoarthritis and rheumatoid arthritis:
Missed Dose
If you miss a dose of Ketoprofen MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ketoprofen MR administration
Take this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Ketoprofen MR should not be used to treat minor aches and pains.
If you take Ketoprofen MR for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.
Store Ketoprofen MR at room temperature, away from moisture, heat, and light.
Ketoprofen MR pharmacology
Ketoprofen MR is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties.
The anti-inflammatory, analgesic, and antipyretic properties of Ketoprofen MR have been demonstrated in classical animal and in vitro test systems. In anti-inflammatory models Ketoprofen MR has been shown to have inhibitory effects on prostaglandin and leukotriene synthesis, to have antibradykinin activity, as well as to have lysosomal membrane-stabilizing action. However, its mode of action, like that of other nonsteroidal anti-inflammatory drugs, is not fully understood.
PHARMACODYNAMICS
Ketoprofen MR is a racemate with only the S enantiomer possessing pharmacological activity. The enantiomers have similar concentration time curves and do not appear to interact with one another.
An analgesic effect-concentration relationship for Ketoprofen MR was established in an oral surgery pain study with Ketoprofen MR (Ketoprofen MR). The effect-site rate constant (kwas prolonged from 1.6 hours in normal subjects to approximately 3 hours in patients with mild renal impairment, and to approximately 5 to 9 hours in patients with moderately to severely impaired renal function.
No studies have been conducted in patients with renal impairment taking Oruvail capsules.
Hepatically impaired
For patients with alcoholic cirrhosis, no significant changes in the kinetic disposition of Ketoprofen MR (Ketoprofen MR) capsules were observed relative to age-matched normal subjects: the plasma clearance of drug was 0.07 L/kg/h in 26 hepatically impaired patients. The elimination half-life was comparable to that observed for normal subjects. However, the unbound (biologically active) fraction was approximately doubled, probably due to hypoalbuminemia and high variability which was observed in the pharmacokinetics for cirrhotic patients. Therefore, these patients should be carefully monitored and daily doses of Ketoprofen MR kept at the minimum providing the desired therapeutic effect.
No studies have been conducted in patients with hepatic impairment taking Oruvail capsules.
CLINICAL TRIALS
Rheumatoid Arthritis and Osteoarthritis
The efficacy of Ketoprofen MR has been demonstrated in patients with rheumatoid arthritis and osteoarthritis. Using standard assessments of therapeutic response, there were no detectable differences in effectiveness or in the incidence of adverse events in crossover comparison of Ketoprofen MR (Ketoprofen MR) and Oruvail (Ketoprofen MR). In other trials, Ketoprofen MR demonstrated effectiveness comparable to aspirin, ibuprofen, naproxen, piroxicam, diclofenac and indomethacin. In some of these studies there were more dropouts due to gastrointestinal side effects among patients on Ketoprofen MR than among patients on other NSAIDs.
In studies with patients with rheumatoid arthritis, Ketoprofen MR was administered in combination with gold salts, antimalarials, low-dose methotrexate, d-penicillamine, and/or corticosteroids with results comparable to those seen with control nonsteroidal drugs.
Management of Pain
The effectiveness of Ketoprofen MR (Ketoprofen MR) as a general-purpose analgesic has been studied in standard pain models which have shown the effectiveness of doses of 25 to 150 mg. Doses of 25 mg were superior to placebo. Doses larger than 25 mg generally could not be shown to be significantly more effective, but there was a tendency toward faster onset and greater duration of action with 50 mg, and, in the case of dysmenorrhea, a significantly greater effect overall with 75 mg. Doses greater than 50 to 75 mg did not have increased analgesic effect. Studies in postoperative pain have shown that Ketoprofen MR (Ketoprofen MR) in doses of 25 to 100 mg was comparable to 650 mg of acetaminophen with 60 mg of codeine, or 650 mg of acetaminophen with 10 mg of oxycodone. Ketoprofen MR tended to be somewhat slower in onset; peak pain relief was about the same and the duration of the effect tended to be 1 to 2 hours longer, particularly with the higher doses of Ketoprofen MR.
The use of Oruvail in patients with acute pain is not recommended, since, in comparison to Ketoprofen MR (Ketoprofen MR), Oruvail would be expected to have a delayed analgesic response due to its extended-release characteristics.
References
- DailyMed. "KETOPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Ketoprofen: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Ketoprofen: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Ketoprofen MR are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ketoprofen MR. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
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Information checked by Dr. Sachin Kumar, MD Pharmacology
