Actions of Lacophen in details
Description: Lacophen has a broad spectrum of activity similar to chloramphenicol. It is less active than chloramphenicol but it is equally effective and more actively bactericidal against Haemophilus and Neisseria spp. It reversibly binds to 50s subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria, thus inhibiting cell growth.
Pharmacokinetics:
Absorption: Peak serum concentrations: 2 hr.
Distribution: Diffuses into the CSF, across the placenta, into breast milk and into the lungs. Protein binding: 10%. Half-life: 2-3 hr, increased in renal impairment.
Metabolism: Undergoes little or no conjugation with glucuronic acid in the liver.
Excretion: Excreted in the urine mainly as unchanged drug (70%); small amount excreted in bile and faeces.
References
- EPA DSStox. "Thiamphenicol: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lacophen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lacophen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
