Leidapharm Paracetamol/Coffeïne indications
Management of duodenal ulcer; treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis; therapy for benign gastric ulcer; treatment of pathologic hypersecretory conditions; prevention of upper GI bleeding.
Unlabeled Uses
Prevention of aspiration pneumonia and stress ulcers; herpes virus infection; chronic idiopathic urticaria; anaphylaxis (relieves dermatologic symptoms only); dyspepsia; used before anesthesia to prevent aspiration pneumonitis; treatment of hyperparathyroidism and control of secondary hyperparathyroidism in chronic hemodialysis patient; treatment of chronic viral warts in children.
Leidapharm Paracetamol/Coffeïne description
Each caplet contains acetaminophen 500 mg and Caffeine (Leidapharm Paracetamol (Leidapharm Paracetamol/Coffeïne)/Coffeïne) 65 mg.
Leidapharm Paracetamol/Coffeïne dosage
Adults and Children ≥12 years: Take 1-2 caplets, every 4-6 hours as required. Do not take more frequently than every 4 hrs. Do not take more than 8 caplets in 24 hours. It can be taken on an empty stomach.
Panadol Extra Advance should not be used with other acetaminophen-containing products. Do not exceed the stated dose.
Leidapharm Paracetamol/Coffeïne interactions
The speed of absorption of Paracetamol (Leidapharm Paracetamol/Coffeïne) may be increased by metoclopramide or domperidone and absorption reduced by colestyramine.
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of Paracetamol (Leidapharm Paracetamol/Coffeïne) with increased risk of bleeding. Occasional doses have no significant effect.
The use of drugs which induce hepatic microsomal enzymes, such as anticonvulsants and oral contraceptive steroids, may increase the extent of metabolism of Paracetamol (Leidapharm Paracetamol/Coffeïne), resulting in reduced plasma concentrations of the drug and a faster elimination rate.
Drugs which induce hepatic microsomal enzymes, such as alcohol and barbiturates, may increase the hepatotoxicity of Paracetamol (Leidapharm Paracetamol/Coffeïne), particularly after overdose.
CNS depression or excitation may occur if codeine is given to patients receiving monoamine oxidase inhibitors, or within two weeks of stopping treatment with them. The effects of CNS depressants (including alcohol) may be potentiated by codeine.
Concurrent use of codeine with antidiarrhoeal and antiperistaltic agents may increase the risk of severe constipation. Concomitant use of antimuscarinics or medications with antimuscarinic action may result in an increased risk of severe constipation, which may lead to paralytic ileus and/or urinary retention.
Quinidine can inhibit the analgesic effect of codeine.
Codeine may delay the absorption of mexiletine and thus reduce the antiarrhythmic effect of the latter. Codeine may antagonise the gastrointestinal effects of metoclopramide and domperidone. Cimetidine inhibits the metabolism of opioid analgesics resulting in increased plasma concentrations.
Naltrexone blocks the therapeutic effect of opioids.
Leidapharm Paracetamol/Coffeïne side effects
Adverse effects of Paracetamol (Leidapharm Paracetamol/Coffeïne) are rare, but hypersensitivity including skin rash may occur. There have been a few reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these were not necessarily causally related to Paracetamol (Leidapharm Paracetamol/Coffeïne).
Codeine can produce constipation and drowsiness. Occasional effects are nausea, vomiting, sweating, facial flushing, dry mouth, blurred or double vision, dizziness, postural hypotension, headache, vertigo, palpitations, allergic reactions (itch, skin rash, facial oedema), and difficulties in micturition (dysuria, increased frequency, decrease in amount). Side-effects which occur rarely include hallucinations, nightmares, restlessness and stomach cramps. The frequency and severity are determined by dosage, duration of treatment and individual sensitivity and are unlikely at this dosage. Tolerance and dependency can occur, especially with prolonged high doses of codeine.
High doses of Caffeine (Leidapharm Paracetamol (Leidapharm Paracetamol/Coffeïne)/Coffeïne) may produce headache, tremor, nervousness and irritability.
Leidapharm Paracetamol/Coffeïne contraindications
Do not use with an MAOI or within 14 days of discontinuing an MAOI
due to risk of drug interaction. At least 5 weeks should be allowed after
stopping FLUOXETINE before treatment with an MAOI
• Do not use with pimozide due to risk of drug interaction or QTc
prolongation
• Do not use with thioridazine due to QTc interval prolongation or
potential for elevated thioridazine plasma levels. Do not use thioridazine
within 5 weeks of discontinuing FLUOXETINE
Active ingredient matches for Leidapharm Paracetamol/Coffeïne:
Caffeine/Paracetamol in Netherlands.
List of Leidapharm Paracetamol/Coffeïne substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Kruidvat Paracetamol met coffeine (Netherlands) | |
| Lemsip Max Relief Capsules (Ireland) | |
| Li Tong (China) | |
| Livsane Paracetamol met Coffeïne (Netherlands) | |
| Lokman kase (Turkey) | |
| Lonarid N (Belgium) | |
| Mann (Belgium) | |
| Maxidrin (Brazil) | |
| Medafein (Turkey) | |
| METACIN EXS | |
| METACIN EXS TABLET 1 strip / 10 tablets each (Themis Medicare Ltd) | $ 0.21 |
| METACIN-EXS (India) | |
| METACIN-EXS tab 10's (Themis (Pro. Chemosyn)) | $ 0.22 |
| Midolen (Peru) | |
| Midrone (Oman) | |
| Migradin Forte (Peru) | |
| Minoset plus (Turkey) | |
| Miralgin (Germany, Hungary) | |
| Molfen (Egypt) | |
| MOLFEN 400MG/500MG TABLET 1 strip / 10 tablets each (Seagull Labs (I) Pvt Ltd) | $ 0.51 |
| Molfen Tablet (Seagull Pharmaceutical Pvt Ltd) | $ 0.05 |
| NEDAC SORBO Paracetamol/Coffeine (Netherlands) | |
| Neopyrin (Germany) | |
| Capsule; Oral; Acetaminophen; Caffeine (Riemser) | |
| Newcetamol | |
| Nongripp Migrana (Peru) | |
| Nongripp MigraГ±a (Peru) | |
| Nor Plus (Bangladesh) | |
| Novadol extra (Tunisia) | |
| NOVALGIN NU | |
| NOVALGIN NU 50 MG/650 MG TABLET 1 strip / 10 tablets each (Sanofi India Ltd) | $ 0.26 |
| Novalgin-NU (India) | |
| Novalgin-NU Paracetamol 650 mg, caffeine50 mg. TAB / 10 (Sanofi Aventis) | $ 0.24 |
| NOVALGIN-NU tab 10's (Sanofi Aventis) | $ 0.24 |
| Nygen (Portugal) | |
| Octadon P (Germany) | |
| Tablet; Oral; Acetaminophen; Caffeine (Ucb) | |
| Omol Extra (Oman) | |
| Opadol (Paraguay) | |
| Optalidon Schmerztabletten (Germany) | |
| Oskadon (Indonesia) | |
| Oskadon 4's (Supra ferbindo) | $ 0.12 |
| Pabialgin Neo (Poland) | |
| Pac (Bangladesh) | |
| PACIMOL ACTIVE | |
| PACIMOL ACTIVE 50 MG/650 MG TABLET 1 strip / 10 tablets each (Ipca Laboratories Ltd) | $ 0.33 |
| Panadol Coffein (Finland) | |
| Panadol Cold&Flu Relief (Ireland) | |
| Panadol Comp (Finland) | |
| Panadol Extra (Bangladesh, Bulgaria, Croatia (Hrvatska), Estonia, Greece, Hong Kong, Ireland, Latvia, Lithuania, Malta, New Zealand, Oman, Peru, Poland, Romania, Russian Federation, Serbia, Singapore, Slovakia, Slovenia, Switzerland, Taiwan, Tunisia, Turkey, United Kingdom, Vietnam) | |
| Tablet, Effervescent; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Sterling) | |
| Tablet, Film-Coated; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Sterling) | |
See 437 substitutes for Leidapharm Paracetamol/Coffeïne | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "caffeine". http://www.drugbank.ca/drugs/DB00201 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Leidapharm Paracetamol/Coffeïne are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Leidapharm Paracetamol/Coffeïne. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
