Dosage of Levocarb - 1 A Pharma in details
Dosage in Patients Naïve to Levodopa (Levocarb - 1 A Pharma) Therapy
The recommended starting dosage of Levocarb - 1 A Pharma in Levodopa (Levocarb - 1 A Pharma)-naïve patients is 23.75 mg / 95 mg taken orally three times a day for the first 3 days. On the fourth day of treatment, the dosage of Levocarb - 1 A Pharma may be increased to 36.25 mg / 145 mg taken three times a day.
Based upon individual patient clinical response and tolerability, the Levocarb - 1 A Pharma dose may be increased up to a maximum recommended dose of 97.5 mg / 390 mg taken three times a day. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levocarb - 1 A Pharma is 612.5 mg / 2450 mg.
Maintain patients on the lowest dosage required to achieve symptomatic control and to minimize adverse reactions such as dyskinesia and nausea.
Converting from Immediate-Release Carbidopa (Levocarb - 1 A Pharma)-Levodopa (Levocarb - 1 A Pharma) to Levocarb - 1 A Pharma
To convert patients from immediate-release Carbidopa (Levocarb - 1 A Pharma)-Levodopa (Levocarb - 1 A Pharma) to Levocarb - 1 A Pharma, determine the recommended starting dosage of Levocarb - 1 A Pharma using Table 1.
The dosages of other Carbidopa (Levocarb - 1 A Pharma) and Levodopa (Levocarb - 1 A Pharma) products are not interchangeable with the dosages of Levocarb - 1 A Pharma.
Adjust the dose to maintain patient tolerance and sufficient symptomatic control. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levocarb - 1 A Pharma is 612.5 mg / 2450 mg.
For patients currently treated with Carbidopa (Levocarb - 1 A Pharma) and Levodopa (Levocarb - 1 A Pharma) plus catechol-O-methyl transferase (COMT) inhibitors (such as entacapone), the initial total daily dose of Levodopa (Levocarb - 1 A Pharma) in Levocarb - 1 A Pharma described in Table 1 may need to be increased.
Use of Levocarb - 1 A Pharma in combination with other Levodopa (Levocarb - 1 A Pharma) products has not been studied.
| Total Daily Dose of Levodopa (Levocarb - 1 A Pharma) in Immediate-Release Carbidopa (Levocarb - 1 A Pharma)-Levodopa (Levocarb - 1 A Pharma) | Recommended Starting Dosage of Levocarb - 1 A Pharma | |
|---|---|---|
| Total Daily Dose of Levodopa (Levocarb - 1 A Pharma) in Levocarb - 1 A Pharma | Levocarb - 1 A Pharma Dosing Regimen | |
| ||
| 400 mg to 549 mg | 855 mg | 3 capsules Levocarb - 1 A Pharma 23.75 mg / 95 mg taken TID* |
| 550 mg to 749 mg | 1140 mg | 4 capsules Levocarb - 1 A Pharma 23.75 mg / 95 mg taken TID |
| 750 mg to 949 mg | 1305 mg | 3 capsules Levocarb - 1 A Pharma 36.25 mg / 145 mg taken TID |
| 950 mg to 1249 mg | 1755 mg | 3 capsules Levocarb - 1 A Pharma 48.75 mg / 195 mg taken TID |
| Equal to or greater than 1250 mg | 2340 mg or | 4 capsules Levocarb - 1 A Pharma 48.75 mg / 195 mg taken TID or |
| 2205 mg | 3 capsules Levocarb - 1 A Pharma 61.25 mg / 245 mg taken TID | |
Discontinuation of Levocarb - 1 A Pharma
Avoid sudden discontinuation or rapid dose reduction of Levocarb - 1 A Pharma. The daily dose of Levocarb - 1 A Pharma should be tapered at the time of treatment discontinuation.
Administration Information
Swallow Levocarb - 1 A Pharma whole with or without food. A high-fat, high-calorie meal may delay the absorption of Levodopa (Levocarb - 1 A Pharma) by about 2 hours.
Do not chew, divide or crush Levocarb - 1 A Pharma capsules. For patients who have difficulty swallowing intact capsules, administer Levocarb - 1 A Pharma by carefully opening the capsule, sprinkling the entire contents on a small amount of applesauce (1 to 2 tablespoons), and consuming immediately. Do not store the drug/food mixture for future use.
What other drugs will affect Levocarb - 1 A Pharma?
Taking Levocarb - 1 A Pharma with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Levocarb - 1 A Pharma with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
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isoniazid;
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metoclopramide;
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blood pressure medication;
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medicines, vitamins, or mineral supplements that contain iron; or
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medicine to treat a psychiatric disorder (such as Abilify, Geodon, Risperdal, Seroquel, Symbyax, or Zyprexa).
This list is not complete. Other drugs may interact with Carbidopa (Levocarb - 1 A Pharma) and Levodopa (Levocarb - 1 A Pharma), including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Levocarb - 1 A Pharma drug interactions (more detail)
Levocarb - 1 A Pharma interactions
Caution should be exercised when the following drugs are administered concomitantly with Levocarb - 1 A Pharma.
Symptomatic postural hypotension occurred when Levocarb - 1 A Pharma was added to the treatment of a patient receiving antihypertensive drugs. Therefore, when therapy with Levocarb - 1 A Pharma is started, dosage adjustment of the antihypertensive drug may be required.
For patients receiving MAO inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and Carbidopa (Levocarb - 1 A Pharma) Levodopa (Levocarb - 1 A Pharma) may be associated with severe orthostatic hypotension not attributable to Carbidopa (Levocarb - 1 A Pharma) Levodopa (Levocarb - 1 A Pharma) alone.
There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and Levocarb - 1 A Pharma.
Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of Levodopa (Levocarb - 1 A Pharma). In addition, the beneficial effects of Levodopa (Levocarb - 1 A Pharma) in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Levocarb - 1 A Pharma should be carefully observed for loss of therapeutic response.
Use of Levocarb - 1 A Pharma with dopamine-depleting agents (e.g., reserpine and tetrabenazine) or other drugs known to deplete monoamine stores is not recommended.
Levocarb - 1 A Pharma and iron salts or multivitamins containing iron salts should be coadministered with caution. Iron salts can form chelates with Levodopa (Levocarb - 1 A Pharma) and Carbidopa (Levocarb - 1 A Pharma) and consequently reduce the bioavailability of Carbidopa (Levocarb - 1 A Pharma) and Levodopa (Levocarb - 1 A Pharma).
Although metoclopramide may increase the bioavailability of Levodopa (Levocarb - 1 A Pharma) by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.
References
- DailyMed. "CARBIDOPA; ENTACAPONE; LEVODOPA: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "KR87B45RGH: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
