Dosage of Levocarb-GRY in details
Dosage in Patients Naïve to Levodopa (Levocarb-GRY) Therapy
The recommended starting dosage of Levocarb-GRY in Levodopa (Levocarb-GRY)-naïve patients is 23.75 mg / 95 mg taken orally three times a day for the first 3 days. On the fourth day of treatment, the dosage of Levocarb-GRY may be increased to 36.25 mg / 145 mg taken three times a day.
Based upon individual patient clinical response and tolerability, the Levocarb-GRY dose may be increased up to a maximum recommended dose of 97.5 mg / 390 mg taken three times a day. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levocarb-GRY is 612.5 mg / 2450 mg.
Maintain patients on the lowest dosage required to achieve symptomatic control and to minimize adverse reactions such as dyskinesia and nausea.
Converting from Immediate-Release Carbidopa (Levocarb-GRY)-Levodopa (Levocarb-GRY) to Levocarb-GRY
To convert patients from immediate-release Carbidopa (Levocarb-GRY)-Levodopa (Levocarb-GRY) to Levocarb-GRY, determine the recommended starting dosage of Levocarb-GRY using Table 1.
The dosages of other Carbidopa (Levocarb-GRY) and Levodopa (Levocarb-GRY) products are not interchangeable with the dosages of Levocarb-GRY.
Adjust the dose to maintain patient tolerance and sufficient symptomatic control. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levocarb-GRY is 612.5 mg / 2450 mg.
For patients currently treated with Carbidopa (Levocarb-GRY) and Levodopa (Levocarb-GRY) plus catechol-O-methyl transferase (COMT) inhibitors (such as entacapone), the initial total daily dose of Levodopa (Levocarb-GRY) in Levocarb-GRY described in Table 1 may need to be increased.
Use of Levocarb-GRY in combination with other Levodopa (Levocarb-GRY) products has not been studied.
| Total Daily Dose of Levodopa (Levocarb-GRY) in Immediate-Release Carbidopa (Levocarb-GRY)-Levodopa (Levocarb-GRY) | Recommended Starting Dosage of Levocarb-GRY | |
|---|---|---|
| Total Daily Dose of Levodopa (Levocarb-GRY) in Levocarb-GRY | Levocarb-GRY Dosing Regimen | |
| ||
| 400 mg to 549 mg | 855 mg | 3 capsules Levocarb-GRY 23.75 mg / 95 mg taken TID* |
| 550 mg to 749 mg | 1140 mg | 4 capsules Levocarb-GRY 23.75 mg / 95 mg taken TID |
| 750 mg to 949 mg | 1305 mg | 3 capsules Levocarb-GRY 36.25 mg / 145 mg taken TID |
| 950 mg to 1249 mg | 1755 mg | 3 capsules Levocarb-GRY 48.75 mg / 195 mg taken TID |
| Equal to or greater than 1250 mg | 2340 mg or | 4 capsules Levocarb-GRY 48.75 mg / 195 mg taken TID or |
| 2205 mg | 3 capsules Levocarb-GRY 61.25 mg / 245 mg taken TID | |
Discontinuation of Levocarb-GRY
Avoid sudden discontinuation or rapid dose reduction of Levocarb-GRY. The daily dose of Levocarb-GRY should be tapered at the time of treatment discontinuation.
Administration Information
Swallow Levocarb-GRY whole with or without food. A high-fat, high-calorie meal may delay the absorption of Levodopa (Levocarb-GRY) by about 2 hours.
Do not chew, divide or crush Levocarb-GRY capsules. For patients who have difficulty swallowing intact capsules, administer Levocarb-GRY by carefully opening the capsule, sprinkling the entire contents on a small amount of applesauce (1 to 2 tablespoons), and consuming immediately. Do not store the drug/food mixture for future use.
What other drugs will affect Levocarb-GRY?
Taking Levocarb-GRY with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Levocarb-GRY with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
-
isoniazid;
-
metoclopramide;
-
blood pressure medication;
-
medicines, vitamins, or mineral supplements that contain iron; or
-
medicine to treat a psychiatric disorder (such as Abilify, Geodon, Risperdal, Seroquel, Symbyax, or Zyprexa).
This list is not complete. Other drugs may interact with Carbidopa (Levocarb-GRY) and Levodopa (Levocarb-GRY), including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Levocarb-GRY drug interactions (more detail)
Levocarb-GRY interactions
Caution should be exercised when the following drugs are administered concomitantly with Levocarb-GRY.
Symptomatic postural hypotension occurred when Levocarb-GRY was added to the treatment of a patient receiving antihypertensive drugs. Therefore, when therapy with Levocarb-GRY is started, dosage adjustment of the antihypertensive drug may be required.
For patients receiving MAO inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and Carbidopa (Levocarb-GRY) Levodopa (Levocarb-GRY) may be associated with severe orthostatic hypotension not attributable to Carbidopa (Levocarb-GRY) Levodopa (Levocarb-GRY) alone.
There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and Levocarb-GRY.
Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of Levodopa (Levocarb-GRY). In addition, the beneficial effects of Levodopa (Levocarb-GRY) in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Levocarb-GRY should be carefully observed for loss of therapeutic response.
Use of Levocarb-GRY with dopamine-depleting agents (e.g., reserpine and tetrabenazine) or other drugs known to deplete monoamine stores is not recommended.
Levocarb-GRY and iron salts or multivitamins containing iron salts should be coadministered with caution. Iron salts can form chelates with Levodopa (Levocarb-GRY) and Carbidopa (Levocarb-GRY) and consequently reduce the bioavailability of Carbidopa (Levocarb-GRY) and Levodopa (Levocarb-GRY).
Although metoclopramide may increase the bioavailability of Levodopa (Levocarb-GRY) by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.
References
- DailyMed. "CARBIDOPA; ENTACAPONE; LEVODOPA: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "KR87B45RGH: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Levocarb-GRY are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Levocarb-GRY. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yet1 consumer reported doses
What doses of Levocarb-GRY drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Levocarb-GRY drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 201-500mg | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
