What is Levodopa + Carbidopa Memphis?
Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) combination is used to treat Parkinson's disease, sometimes called shaking palsy or paralysis agitans. Parkinson's disease is a disorder of the central nervous system (brain and spinal cord).
Extended-release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) (Levodopa + Carbidopa Memphis®) is also used to treat parkinsonism caused by encephalitis, or parkinsonism caused by carbon monoxide or manganese poisoning.
Dopamine is a naturally occurring substance in the brain that helps provide control of movement and activities such as walking and talking. In patients with Parkinson's disease, there is not enough dopamine in some parts of the brain. Levodopa (Levodopa + Carbidopa Memphis) enters the brain and helps replace the missing dopamine, which allows people to function better. By increasing the amount of dopamine in the brain, Levodopa (Levodopa + Carbidopa Memphis) helps control symptoms and helps you to perform daily activities such as dressing, walking, and handling utensils.
Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) is available only with your doctor's prescription.
Levodopa + Carbidopa Memphis indications
Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets are indicated in the treatment of the symptoms of idiopathic Parkinson’s disease (paralysis agitans), postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets are indicated in these conditions to permit the administration of lower doses of Levodopa (Levodopa + Carbidopa Memphis) with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother response, and with supplemental pyridoxine (vitamin B6).
In some patients, a somewhat smoother antiparkinsonian effect results from therapy with Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) than with Levodopa (Levodopa + Carbidopa Memphis). However, patients with markedly irregular (“on-off”) responses to Levodopa (Levodopa + Carbidopa Memphis) have not been shown to benefit from Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) therapy.
Although the administration of Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) permits control of parkinsonism and Parkinson’s disease with much lower doses of Levodopa (Levodopa + Carbidopa Memphis), there is no conclusive evidence at present that this is beneficial other than in reducing nausea and vomiting, permitting more rapid titration, and providing a somewhat smoother response to Levodopa (Levodopa + Carbidopa Memphis).
Certain patients who responded poorly to Levodopa (Levodopa + Carbidopa Memphis) have improved when Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) was substituted. This is most likely due to decreased peripheral decarboxylation of Levodopa (Levodopa + Carbidopa Memphis) which results from administration of Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) rather than to a primary effect of Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) on the nervous system. Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) has not been shown to enhance the intrinsic efficacy of Levodopa (Levodopa + Carbidopa Memphis) in parkinsonian syndromes.
In considering whether to give Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets to patients already on Levodopa (Levodopa + Carbidopa Memphis) who have nausea and/or vomiting, the practitioner should be aware that, while many patients may be expected to improve, some do not. Since one cannot predict which patients are likely to improve, this can only be determined by a trial of therapy. It should be further noted that in controlled trials comparing Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) with Levodopa (Levodopa + Carbidopa Memphis), about half of the patients with nausea and/or vomiting on Levodopa (Levodopa + Carbidopa Memphis) improved spontaneously despite being retained on the same dose of Levodopa (Levodopa + Carbidopa Memphis) during the controlled portion of the trial.
How should I use Levodopa + Carbidopa Memphis?
Use Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) by mouth with or without food.
- If you take an iron product or a multivitamin that contains iron, ask your doctor or pharmacist how to take it with Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis). Iron may decrease your body's ability to absorb Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis).
- Diets that are high in some contents (eg, protein, fat, calories) may decrease your body's ability to absorb Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis). Discuss any questions or concerns with your doctor. Tell your doctor if you have a diet that is high in protein, fat, or calories or if you will be changing your diet.
- Carefully follow the dosing schedule given to you by your health care provider.
- Take Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) on a regular schedule to get the most benefit from it. Taking Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) at the same times each day will help you to remember to take it.
- Continue to take Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) even if you feel well. Do not miss any doses.
- If you have been taking Levodopa (Levodopa + Carbidopa Memphis), do not start taking Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) until at least 12 hours after your final dose of Levodopa (Levodopa + Carbidopa Memphis).
- Do not suddenly stop taking Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) or lower your dose without checking with your doctor. Side effects may occur. Discuss any questions or concerns with your doctor.
- If you miss a dose of Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis).
Uses of Levodopa + Carbidopa Memphis in details
This medication is used to treat symptoms of Parkinson's disease (such as shakiness, stiffness, difficulty moving).
Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain. Levodopa (Levodopa + Carbidopa Memphis) changes into dopamine in the brain, helping to control movement. Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) prevents the breakdown of Levodopa (Levodopa + Carbidopa Memphis) in the bloodstream so more Levodopa (Levodopa + Carbidopa Memphis) can enter the brain. Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) can also reduce some of Levodopa (Levodopa + Carbidopa Memphis)'s side effects such as nausea and vomiting.
By giving this medication as a continuous infusion, it can help reduce the amount of "off" time (periods of slow movement or stiffness).
How to use Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) via j-tube
Read the Medication Guide and the Instructions for Use provided by your health care professional before you start using this medication and each time you get a refill. If you have any questions, ask your health care professional.
Give this medication as directed as a continuous infusion into the small intestine using an infusion pump. It is usually given over 16 hours a day and stopped at bedtime. At bedtime, take your dose of immediate-release Levodopa + Carbidopa Memphis tablets by mouth as directed.
When you first start using this medication, it is given through a tube through the nose into the small intestine. After a few days, if the doctor decides that this product is right for you, then the medication will be given through a tube through the abdomen into the small intestine. Getting the tube through the abdomen will require surgery.
Follow all instructions from your health care professional about how to properly use this medication and the infusion pump. Take a cassette containing the medication from the refrigerator and leave it at room temperature for 20 minutes before using. Do not use a cassette for longer than 16 hours or re-use it, even if there is medication left in it. Learn how to store and discard medical supplies safely. Also learn how to properly care for the small hole in your abdomen and the skin area around the tube, and how to avoid infection.
The dosage is based on your medical condition and response to treatment. Your daily dose is made up of a morning dose, a continuous dose, and extra doses. An extra dose is a small dose of this medication that can be given as needed during the day to treat sudden "off" symptoms. Extra doses should not be given more often than one every 2 hours to avoid causing or worsening movements you cannot control.
Do not suddenly decrease the dose or suddenly stop using this medication because doing either may lead to a serious condition. If you must stop this medication, slowly reduce the dose as directed by your doctor. Contact your doctor right away if your infusion is interrupted. You may need to take the tablet form of Levodopa + Carbidopa Memphis by mouth.
If you plan to be disconnected from the pump for a short period of time (less than 2 hours, for example, to shower), ask your doctor ahead of time if you should use an extra dose of this medication before you disconnect. If you plan to be disconnected from the pump for longer than 2 hours, ask your doctor what you should do and discuss how you should take Levodopa + Carbidopa Memphis tablets by mouth during this time.
Avoid high-protein diets because they may reduce how much of the medication you can absorb.
Tell your doctor if your condition does not improve or if it worsens.
Levodopa + Carbidopa Memphis description
The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Levodopa + Carbidopa Memphis dosage
Dosage in Patients Naïve to Levodopa (Levodopa + Carbidopa Memphis) Therapy
The recommended starting dosage of Levodopa + Carbidopa Memphis in Levodopa (Levodopa + Carbidopa Memphis)-naïve patients is 23.75 mg / 95 mg taken orally three times a day for the first 3 days. On the fourth day of treatment, the dosage of Levodopa + Carbidopa Memphis may be increased to 36.25 mg / 145 mg taken three times a day.
Based upon individual patient clinical response and tolerability, the Levodopa + Carbidopa Memphis dose may be increased up to a maximum recommended dose of 97.5 mg / 390 mg taken three times a day. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levodopa + Carbidopa Memphis is 612.5 mg / 2450 mg.
Maintain patients on the lowest dosage required to achieve symptomatic control and to minimize adverse reactions such as dyskinesia and nausea.
Converting from Immediate-Release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) to Levodopa + Carbidopa Memphis
To convert patients from immediate-release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) to Levodopa + Carbidopa Memphis, determine the recommended starting dosage of Levodopa + Carbidopa Memphis using Table 1.
The dosages of other Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) products are not interchangeable with the dosages of Levodopa + Carbidopa Memphis.
Adjust the dose to maintain patient tolerance and sufficient symptomatic control. The dosing frequency may be changed from three times a day to a maximum of five times a day if more frequent dosing is needed and if tolerated. The maximum recommended daily dose of Levodopa + Carbidopa Memphis is 612.5 mg / 2450 mg.
For patients currently treated with Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) plus catechol-O-methyl transferase (COMT) inhibitors (such as entacapone), the initial total daily dose of Levodopa (Levodopa + Carbidopa Memphis) in Levodopa + Carbidopa Memphis described in Table 1 may need to be increased.
Use of Levodopa + Carbidopa Memphis in combination with other Levodopa (Levodopa + Carbidopa Memphis) products has not been studied.
| Total Daily Dose of Levodopa (Levodopa + Carbidopa Memphis) in Immediate-Release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) | Recommended Starting Dosage of Levodopa + Carbidopa Memphis | |
|---|---|---|
| Total Daily Dose of Levodopa (Levodopa + Carbidopa Memphis) in Levodopa + Carbidopa Memphis | Levodopa + Carbidopa Memphis Dosing Regimen | |
| ||
| 400 mg to 549 mg | 855 mg | 3 capsules Levodopa + Carbidopa Memphis 23.75 mg / 95 mg taken TID* |
| 550 mg to 749 mg | 1140 mg | 4 capsules Levodopa + Carbidopa Memphis 23.75 mg / 95 mg taken TID |
| 750 mg to 949 mg | 1305 mg | 3 capsules Levodopa + Carbidopa Memphis 36.25 mg / 145 mg taken TID |
| 950 mg to 1249 mg | 1755 mg | 3 capsules Levodopa + Carbidopa Memphis 48.75 mg / 195 mg taken TID |
| Equal to or greater than 1250 mg | 2340 mg or | 4 capsules Levodopa + Carbidopa Memphis 48.75 mg / 195 mg taken TID or |
| 2205 mg | 3 capsules Levodopa + Carbidopa Memphis 61.25 mg / 245 mg taken TID | |
Discontinuation of Levodopa + Carbidopa Memphis
Avoid sudden discontinuation or rapid dose reduction of Levodopa + Carbidopa Memphis. The daily dose of Levodopa + Carbidopa Memphis should be tapered at the time of treatment discontinuation.
Administration Information
Swallow Levodopa + Carbidopa Memphis whole with or without food. A high-fat, high-calorie meal may delay the absorption of Levodopa (Levodopa + Carbidopa Memphis) by about 2 hours.
Do not chew, divide or crush Levodopa + Carbidopa Memphis capsules. For patients who have difficulty swallowing intact capsules, administer Levodopa + Carbidopa Memphis by carefully opening the capsule, sprinkling the entire contents on a small amount of applesauce (1 to 2 tablespoons), and consuming immediately. Do not store the drug/food mixture for future use.
Levodopa + Carbidopa Memphis interactions
See also:
What other drugs will affect Levodopa + Carbidopa Memphis?
Monoamine Oxidase (MAO) Inhibitors
The use of nonselective MAO inhibitors with Levodopa + Carbidopa Memphis is contraindicated. Discontinue use of any nonselective MAO inhibitors at least two weeks prior to initiating Levodopa + Carbidopa Memphis.
The use of selective MAO-B inhibitors (e.g., rasagiline and selegiline) with Levodopa + Carbidopa Memphis may be associated with orthostatic hypotension. Monitor patients who are taking these drugs.
Antihypertensive Drugs
The concurrent use of Levodopa + Carbidopa Memphis with antihypertensive medications can cause symptomatic postural hypotension. A dose reduction of the antihypertensive medication may be needed after starting or increasing the dose of Levodopa + Carbidopa Memphis.
Dopamine D2 Receptor Antagonists And Isoniazid
Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone, metoclopramide, papaverine) and isoniazid may reduce the effectiveness of Levodopa (Levodopa + Carbidopa Memphis). Monitor patients for worsening Parkinson's symptoms.
Iron Salts
Iron salts or multi-vitamins containing iron salts can form chelates with Levodopa (Levodopa + Carbidopa Memphis), Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis), and can cause a reduction in the bioavailability of Levodopa + Carbidopa Memphis. If iron salts or multi-vitamins containing iron salts are co-administered with Levodopa + Carbidopa Memphis, monitor patients for worsening Parkinson's symptoms.
High-Protein Diet
Because Levodopa (Levodopa + Carbidopa Memphis) competes with certain amino acids for transport across the gut wall, the absorption of Levodopa (Levodopa + Carbidopa Memphis) may be decreased in patients on a high-protein diet. Advise patients that a high-protein diet may reduce the effectiveness of Levodopa + Carbidopa Memphis.
Levodopa + Carbidopa Memphis side effects
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What are the possible side effects of Levodopa + Carbidopa Memphis?
The following serious adverse reactions are discussed below and elsewhere in the labeling:
- Falling asleep during activities of daily living and somnolence
- Withdrawal-emergent hyperpyrexia and confusion
- Cardiovascular ischemic events
- Hallucinations/psychosis
- Impulse control/compulsive behaviors
- Dyskinesia
- Peptic Ulcer Disease
- Glaucoma
- Melanoma
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
The safety population consisted of a total of 978 Parkinson's disease patients who received at least one dose of Levodopa + Carbidopa Memphis, and had an average duration of exposure of 40 weeks.
Adverse Reactions In Early Parkinson's Disease
In a placebo-controlled clinical study in patients with early Parkinson's disease (Study 1), the most common adverse reactions with Levodopa + Carbidopa Memphis (in at least 5% of patients and more frequently than in placebo) were nausea, dizziness, headache, insomnia, abnormal dreams, dry mouth, dyskinesia, anxiety, constipation, vomiting, and orthostatic hypotension.
Table 2 lists adverse reactions occurring in at least 5% of Levodopa + Carbidopa Memphis-treated patients and at a higher rate than placebo in Study 1.
Table 2: Adverse Reactions in Study 1 in Patients with Early Stage Parkinson's Disease
| Placebo | Levodopa + Carbidopa Memphis 36.25 mg Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) 145 mg Levodopa (Levodopa + Carbidopa Memphis) TID | Levodopa + Carbidopa Memphis 61.25 mg Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) 245 mg Levodopa (Levodopa + Carbidopa Memphis) TID | Levodopa + Carbidopa Memphis 97.5 mg Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) 390 mg Levodopa (Levodopa + Carbidopa Memphis) TID | |
| (N=92) % | (N=87) % | (N=104) % | (N=98) % | |
| Nausea | 9 | 14 | 19 | 20 |
| Dizziness | 5 | 9 | 19 | 12 |
| Headache | 11 | 7 | 13 | 17 |
| Insomnia | 3 | 2 | 9 | 6 |
| Abnormal Dreams | 0 | 2 | 6 | 5 |
| Dry Mouth | 1 | 3 | 2 | 7 |
| Dyskinesia | 0 | 2 | 4 | 5 |
| Anxiety | 0 | 2 | 3 | 5 |
| Constipation | 1 | 2 | 6 | 2 |
| Vomiting | 3 | 2 | 2 | 5 |
| Orthostatic | ||||
| Hypotension | 1 | 1 | 1 | 5 |
Adverse Reactions Leading to Discontinuation in Study 1
In Study 1, 12% of patients discontinued Levodopa + Carbidopa Memphis early due to adverse reactions; a higher proportion of patients in the 61.25 mg / 245 mg Levodopa + Carbidopa Memphis-treated group (14%) and in the 97.5 mg / 390 mg Levodopa + Carbidopa Memphis-treated group (15%) experienced adverse reactions leading to early discontinuation compared to (4%) in the placebo group. The most common adverse reactions resulting in early discontinuation were nausea, dizziness, and vomiting.
Adverse Reactions In Advanced Parkinson's Disease
In an active-controlled clinical study in patients with advanced Parkinson's disease (Study 2), the most common adverse reactions with Levodopa + Carbidopa Memphis that occurred during dose conversion or maintenance (in at least 5% of patients and more frequently than on oral immediate-release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis)) were nausea and headache.
Table 3 lists adverse reactions occurring in at least 5% of Levodopa + Carbidopa Memphis-treated patients and at a higher rate than oral immediate-release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) in Study 2.
Table 3: Adverse Reactions in Study 2 in Patients with Advanced Parkinson's Disease
| Period | Levodopa + Carbidopa Memphis (N=201) | Immediate-Release Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis)-Levodopa (Levodopa + Carbidopa Memphis) (N=192) | ||
| Dose Convers ion* | Maintenance | Dose Convers ion* | Maintenance | |
| % | % | % | % | |
| Nausea | 4 | 3 | 6 | 2 |
| Headache | 5 | 1 | 3 | 2 |
| *All patients were converted to Levodopa + Carbidopa Memphis in the open label Dose Conversion period and then received randomized treatment during maintenance. |
Adverse Reactions Leading to Discontinuation in Study 2
In Study 2, 5% of patients discontinued treatment due to adverse reactions during conversion to Levodopa + Carbidopa Memphis. The common adverse reactions leading to discontinuation during dose conversion were dyskinesia, anxiety, dizziness, and on and off phenomenon.
Levodopa + Carbidopa Memphis contraindications
See also:
What is the most important information I should know about Levodopa + Carbidopa Memphis?
Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets. These inhibitors must be discontinued at least two weeks prior to initiating therapy with Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets. Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets may be administered concomitantly with the manufacturer’s recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g., selegiline HCI).
Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets are contraindicated in patients with known hypersensitivity to any component of this drug, and in patients with narrow-angle glaucoma.
Because Levodopa (Levodopa + Carbidopa Memphis) may activate a malignant melanoma, Carbidopa (Levodopa (Levodopa + Carbidopa Memphis) + Carbidopa Memphis) and Levodopa (Levodopa + Carbidopa Memphis) orally disintegrating tablets should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.
Active ingredient matches for Levodopa + Carbidopa Memphis:
Carbidopa/Levodopa in Colombia.
List of Levodopa + Carbidopa Memphis substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Levodopa/Carbidopa/Entacapone Sandoz (Poland) | |
| Levofamil (Chile) | |
| Tablet; Oral; Carbidopa 25 mg; Levodopa 250 mg (Andromaco) | |
| Levohexal (Australia) | |
| Levokom (Lithuania) | |
| Levomed (Hong Kong, Malaysia, Malta, India) | |
| 500 mg x 5's (Mediez) | $ 0.48 |
| Levomed 10 x 10's (Mediez) | |
| Levomed 500mg TAB / 5 (Mediez) | $ 0.48 |
| LEVOMED 250 MG TABLET 1 strip / 5 tablets each (Mediez) | $ 0.12 |
| LEVOMED 500 MG TABLET 1 strip / 5 tablets each (Mediez) | $ 0.19 |
| LEVOMED tab 500 mg x 5's (Mediez) | $ 0.48 |
| Levomed 250mg Tablet (Mediez) | $ 0.02 |
| Levomed 500mg Tablet (Mediez) | $ 0.04 |
| Levomed 25/100/Levomed 25/250 (Thailand) | |
| Levomet (Hong Kong, Singapore, Thailand) | |
| Levomet 10 x 10's (Unison) | |
| Levomet 10 x 10's (Unison) | |
| Levomet 250/25 mg 10 x 10's (Unison) | |
| Levomet 100/25 mg tab 10 x 10's (Unison) | |
| Levomet 100/25 tab 10 x 10's (Unison) | |
| Levomet 250/25 tab 10 x 10's (Unison) | |
| Levopa (Bangladesh) | |
| Levopa-C (India) | |
| Levopa-C Carbidopa 25mg, Levodopa250mg TAB / 10 (Wallace) | $ 0.37 |
| 10's (Wallace) | $ 0.37 |
| Levopa-C Levodopa 250 mg, Carbidopa 25mg. TAB / 10 (Wallace) | $ 0.37 |
| Levopa-C Carbidopa 25mg, Levodopa 250mg TAB / 10 (Wallace) | $ 0.37 |
| LEVOPA-C tab 10's (Wallace) | $ 0.37 |
| Levosynt (Cyprus) | |
| Licebral (Paraguay, Uruguay) | |
| Licebral CR (Paraguay) | |
| Licebral CR 50/200 (Uruguay) | |
| Menesit (Japan) | |
| Mint-Levocarb (Canada) | |
| Nacom (Germany) | |
| Tablet; Oral Carbidopa 100 mg; Levodopa 250 mg (Bms) | |
| Tablet; Oral Carbidopa 200 mg; Levodopa 500 mg (Bms) | |
| Nacom Retard (Germany) | |
| Tablet, Retard; Oral; Carbidopa 100; Levodopa 250 mg | |
| Nakom (Bosnia & Herzegowina, Croatia (Hrvatska), Czech Republic, Estonia, Georgia, Latvia, Lithuania, Poland, Romania, Russian Federation, Serbia, Slovakia, Slovenia) | |
| Tablet; Oral; Carbidopa 25 mg; Levodopa 250 mg (Lek) | |
| Nakom Mite (Poland, Slovenia) | |
| Tablet; Oral; Carbidopa 25 mg; Levodopa 100 mg | |
| Nakom R (Slovenia) | |
| Neodopaston (Japan) | |
| Nervocur (Argentina) | |
| Neudopa (Pakistan) | |
| Nu-Levocarb (Canada) | |
| Tablet; Oral; Carbidopa 10 mg; Levodopa 100 mg (Nu-pharm) | |
| Tablet; Oral; Carbidopa 25 mg; Levodopa 100 mg (Nu-pharm) | |
See 481 substitutes for Levodopa + Carbidopa Memphis | |
References
- DailyMed. "CARBIDOPA; ENTACAPONE; LEVODOPA: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "levodopa". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "carbidopa". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
