What is Lincomycin Hydrochloride?
Lincomycin Hydrochloride is an antibiotic that fights bacteria.
Lincomycin Hydrochloride is used to treat severe bacterial infections in people who cannot use penicillin antibiotics.
Lincomycin Hydrochloride is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.
Lincomycin Hydrochloride may also be used for purposes not listed in this medication guide.
Lincomycin Hydrochloride indications
Lincomycin Hydrochloride, USP is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of antibacterial associated pseudomembranous colitis, as described in the WARNING box, before selecting Lincomycin Hydrochloride the physician should consider the nature of the infection and the suitability of less toxic alternatives (eg, erythromycin).
Indicated surgical procedures should be performed in conjunction with antibacterial therapy.
The drug may be administered concomitantly with other antimicrobial agents when indicated.
Lincomycin Hydrochloride is not indicated in the treatment of minor bacterial infections or viral infections.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Lincomycin Hydrochloride and other antibacterial drugs, Lincomycin Hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Lincomycin Hydrochloride?
Use Lincomycin Hydrochloride as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Lincomycin Hydrochloride is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- If you miss a dose of Lincomycin Hydrochloride, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use Lincomycin Hydrochloride.
Uses of Lincomycin Hydrochloride in details
Lincomycin Hydrochloride is used in treatment of bacterial infections.
Lincomycin Hydrochloride description
An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
Lincomycin Hydrochloride dosage
If significant diarrhea occurs during therapy, this antibacterial should be discontinued.
INTRAMUSCULAR
AdultsSerious infections—600 mg (2 mL) intramuscularly every 24 hours. More severe infections—600 mg (2 mL) intramuscularly every 12 hours or more often.
Pediatric patients over 1 month of age
Serious infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 24 hours. More severe infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 12 hours or more often.
INTRAVENOUS
AdultsThe intravenous dose will be determined by the severity of the infection. For serious infections doses of 600 mg of Lincomycin Hydrochloride (2 mL of Lincomycin Hydrochloride) to 1 gram are given every 8 to 12 hours. For more severe infections these doses may have to be increased. In life-threatening situations daily intravenous doses of as much as 8 grams have been given.
Intravenous doses are given on the basis of 1 gram of Lincomycin Hydrochloride diluted in not less than 100 mL of appropriate solution and infused over a period of not less than one hour.
| Dose | Vol. Diluent | Time |
|---|---|---|
| 600 mg | 100 mL | 1 hr |
| 1 gram | 100 mL | 1 hr |
| 2 grams | 200 mL | 2 hr |
| 3 grams | 300 mL | 3 hr |
| 4 grams | 400 mL | 4 hr |
These doses may be repeated as often as required to the limit of the maximum recommended daily dose of 8 grams of Lincomycin Hydrochloride.
Pediatric patients over 1 month of age
10 to 20 mg/kg/day (5 to 10 mg/lb/day) depending on the severity of the infection may be infused in divided doses as described above for adults.
NOTE: Severe cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate.
SUBCONJUNCTIVAL INJECTION
0.25 mL (75 mg) injected subconjunctivally will result in ocular fluid levels of antibacterial (lasting for at least 5 hours) with MICs sufficient for most susceptible pathogens.
Patients with diminished renal function
When therapy with Lincomycin Hydrochloride is required in individuals with severe impairment of renal function, an appropriate dose is 25 to 30% of that recommended for patients with normally functioning kidneys.
Lincomycin Hydrochloride interactions
See also:
What other drugs will affect Lincomycin Hydrochloride?
Lincomycin Hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used in caution in patients receiving such agents.
Antagonism between Lincomycin Hydrochloride and erythromycin in vitro has been demonstrated. Because of possible clinical significance, the two drugs should not be administered concurrently.
Lincomycin Hydrochloride side effects
See also:
What are the possible side effects of Lincomycin Hydrochloride?
The following reactions have been reported with the use of Lincomycin Hydrochloride:
Gastrointestinal
Glossitis, stomatitis, nausea, vomiting, antibacterial -associated diarrhea and colitis, and pruritus ani. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
Hematopoietic
Neutropenia, leukopenia, agranulocytosis and thrombocytopenic purpura have been reported. There have been rare reports of aplastic anemia and pancytopenia in which Lincomycin Hydrochloride could not be ruled out as the causative agent.
Hypersensitivity Reactions
Hypersensitivity reactions such as angioneurotic edema, serum sickness and anaphylaxis have been reported. Cases of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with Lincomycin Hydrochloride.
Skin and Mucous Membranes
Skin rashes, urticaria and vaginitis and rare instances of exfoliative and vesiculobullous dermatitis have been reported.
Liver
Although no direct relationship of Lincomycin Hydrochloride to liver dysfunction has been established, jaundice and abnormal liver function tests (particularly elevations of serum transaminase) have been observed.
Renal
Although no direct relationship of Lincomycin Hydrochloride to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.
Cardiovascular
After too rapid intravenous administration, rare instances of cardiopulmonary arrest and hypotension have been reported.
Special Senses
Tinnitus and vertigo have been reported occasionally.
Local Reactions
Patients have demonstrated excellent local tolerance to intramuscularly administered Lincomycin Hydrochloride. Reports of pain following injection have been infrequent.
Intravenous administration of Lincomycin Hydrochloride in 250 to 500 mL of 5% dextrose injection or 0.9% sodium chloride injection produced no local irritation or phlebitis.
Lincomycin Hydrochloride contraindications
See also:
What is the most important information I should know about Lincomycin Hydrochloride?
This drug is contraindicated in patients previously found to be hypersensitive to lin-comycin or clindamycin.
Active ingredient matches for Lincomycin Hydrochloride:
Lincomycin Hydrochloride
List of Lincomycin Hydrochloride substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Linatron (Brazil) | |
| Lincomix (Australia, Belgium, Finland, Netherlands, New Zealand, Poland, United States) | |
| Drug Premix; Oral; Lincomycin Hydrochloride 110 g / kg | |
| Drug Premix; Oral; Lincomycin Hydrochloride 44 g / kg | |
| Injectable; Injection; Lincomycin Hydrochloride 100 mg / ml | |
| lincomycin injection | |
| LINK GEL (India) | |
| 2 % w/w x 10g (Ind-Swift) | $ 0.59 |
| Link Gel 2% w/w GEL / 10g (Ind-Swift) | $ 0.59 |
| LINK GEL topical gel 2 % w/w x 10g (Ind-Swift) | $ 0.59 |
| Link Gel 2% w/w GEL / 10g (Ind-Swift) | $ 0.59 |
References
- PubChem. "lincomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "lincomycin". http://www.drugbank.ca/drugs/DB01627 (accessed September 17, 2018).
- MeSH. "Protein Synthesis Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lincomycin Hydrochloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lincomycin Hydrochloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
