What happens if I overdose Lincomycin Hydrochloride?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Lincomycin Hydrochloride:
Lincomycin Hydrochloride is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
Overdose of Lincomycin Hydrochloride in details
Serum levels of Lincomycin Hydrochloride are not appreciably affected by hemodialysis and peritoneal dialysis.
What should I avoid while taking Lincomycin Hydrochloride?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Lincomycin Hydrochloride warnings
Clostridium difficile associated diarrhea
Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Lincomycin Hydrochloride, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibacterial use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
If CDAD is suspected or confirmed, ongoing antibacterial use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.
Hypersensitivity
Serious hypersensitivity reactions, including anaphylaxis and erythema multiforme, have been reported with use of Lincomycin Hydrochloride. If an allergic reaction to Lincomycin Hydrochloride occurs, discontinue the drug.
Benzyl Alcohol Toxicity in Pediatric Patients (Gasping Syndrome")
This product contains benzyl alcohol as a preservative.
The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.
Use in Meningitis — Although Lincomycin Hydrochloride appears to diffuse into cerebrospinal fluid, levels of Lincomycin Hydrochloride in the CSF may be inadequate for the treatment of meningitis.
What should I discuss with my healthcare provider before taking Lincomycin Hydrochloride?
You should not receive this medication if you are allergic to Lincomycin Hydrochloride or clindamycin.
Antibiotic medicine can cause overgrowth of normally harmless bacteria in the intestines. This can lead to an infection that causes mild to severe diarrhea, even months after your last antibiotic dose. If left untreated this condition can lead to life-threatening intestinal problems. Before you receive Lincomycin Hydrochloride, tell your doctor if you have a history of intestinal disorder such as ulcerative colitis.
Older adults and those who are ill or debilitated may be more sensitive to the effects of diarrhea caused by this medication.
To make sure Lincomycin Hydrochloride is safe for you, also tell your doctor if you have:
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asthma;
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severe allergies; or
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liver or kidney disease.
FDA pregnancy category C. It is not known whether Lincomycin Hydrochloride will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Lincomycin Hydrochloride can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Lincomycin Hydrochloride precautions
1. Discard medicated drinking water if not used within 2 days. Fresh stock solution should be prepared daily. 2. If clinical signs of bloody scours (watery, mucoid or bloody stools) have not improved during the first 6 days of medication, discontinue treatment and redetermine the diagnosis. 3. Occasionally, swine fed Lincomycin Hydrochloride may within the first two days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within five to eight days without discontinuing the Lincomycin Hydrochloride treatment. 4. The safety of Lincomycin Hydrochloride has not been demonstrated for pregnant swine or swine intended for breeding. 5. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to water containing Lincomycin Hydrochloride. Ingestion by these species may result in severe gastrointestinal effects. 6. Do not use the water treatment and the feed treatment simultaneously. 7. Not for use in layer and breeder chickens.
What happens if I miss a dose of Lincomycin Hydrochloride?
Since Lincomycin Hydrochloride is usually given by a healthcare professional, it is not likely that you will miss a dose. If you are using Lincomycin Hydrochloride at home, call your doctor for instructions if you miss a dose.
References
- DrugBank. "lincomycin". http://www.drugbank.ca/drugs/DB01627 (accessed September 17, 2018).
- MeSH. "Protein Synthesis Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
