Pregnancy of Lincozaf in details
Lincozaf crosses the placenta at term and can be detected in cord blood and the amniotic fluid (Medina 1963). Lincozaf injection may also contain benzyl alcohol, which may cross the placenta.
Lincozaf breastfeeding
Drug levels of 0.5 to 2.4 mcg/mL have been reported in human breast milk. In 1 study, serum and milk levels measured 6 hours postdose in 9 patients administered 500 mg orally every 6 hours for 3 days averaged 1.37 and 1.28 mcg/mL, respectively, representing a milk to plasma ratio of 0.9. Much lower milk to plasma ratios of 0.13 to 0.17 have also been reported. No adverse effects have been reported in nursing infants.
A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes Comments: The effects in the nursing infant are unknown.
See references
References for pregnancy information
- Mickal A, Dildy GA, Miller HJ "Lincozaf in the treatment of cervicitis and vagini in pregnancy." South Med J 59 (1966): 567-70
- Heineman HS "Letter: Safety of Lincozaf in pregnancy." Am J Obstet Gynecol 125 (1976): 879
- "Product Information. Lincocin (Lincozaf)." Pharmacia and Upjohn, Kalamazoo, MI.
- Duignan NM, Andrews J, Williams JD "Pharmacological studies with Lincozaf in late pregnancy." Br Med J 3 (1973): 75-8
- Mickal A, Panzer JD "The safety of Lincozaf in pregnancy." Am J Obstet Gynecol 121 (1975): 1071-4
- Cerner Multum, Inc. "Australian Product Information." O 0
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 7th ed." Philadelphia, PA: Lippincott Williams & Wilkins (2005):
- Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ():
References for breastfeeding information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 7th ed." Philadelphia, PA: Lippincott Williams & Wilkins (2005):
- Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ():
- "Product Information. Lincocin (Lincozaf)." Pharmacia and Upjohn, Kalamazoo, MI.
- Cerner Multum, Inc. "Australian Product Information." O 0
References
- PubMed Health. "Lincomycin (By injection) (Lincocin): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- FDA Orange Book. "LINCOMYCIN HYDROCHLORIDE: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". https://www.fda.gov/Drugs/Informatio... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
