What is Lipo Red?
Lipo Red (Lipo Red) helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).
Lipo Red is used to treat high cholesterol and high triglyceride levels.
Lipo Red may also be used for purposes not listed in this medication guide.
Lipo Red indications
Primary Hypercholesterolemia or Mixed Dyslipidemia
Lipo Red Capsules are indicated as adjunctive therapy to diet to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (total-c), Triglycerides (TG) and apolopoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in adult patients with primary hypercholesterolemia or mixed dyslipidemia.
Severe Hypertriglyceridemia
Lipo Red Capsules are also indicated as adjunctive therapy to diet for treatment of adult patients with severe hypertriglyceridemia. Improving glycemic control in diabetic patients showing fasting chylomicronemia will usually obviate the need for pharmacologic intervention.
Markedly elevated levels of serum triglycerides (e.g. > 2,000 mg/dL) may increase the risk of developing pancreatitis. The effect of Lipo Red therapy on reducing this risk has not been adequately studied.
Important Limitations of Use
Lipo Red at a dose equivalent to 150 mg was not shown to reduce coronary heart disease morbidity and mortality in 2 large, randomized controlled trials of patients with type 2 diabetes mellitus.
How should I use Lipo Red?
Use Lipo Red capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Some brands of Lipo Red capsules should be taken with food. Some brands may be taken with or without food. Ask your pharmacist if you should take your brand of Lipo Red capsules with food.
- Swallow Lipo Red capsules whole. Do not open, crush, dissolve, or chew before swallowing. If you cannot swallow Lipo Red capsules whole, tell your doctor. You may need a different medicine.
- Take Lipo Red capsules with a full glass of water (8 oz [240 mL]).
- If you also take a bile acid-binding resin (eg, cholestyramine), do not take it within 4 to 6 hours before or 1 hour after taking Lipo Red capsules. Check with your doctor if you have any questions.
- Take Lipo Red capsules on a regular schedule to get the most benefit from it.
- Taking Lipo Red capsules at the same time each day will help you remember to take it.
- Continue to take Lipo Red capsules even if you feel well. Do not miss any doses.
- If you miss a dose of Lipo Red capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Lipo Red capsules.
Uses of Lipo Red in details
Use: Labeled Indications
Hypercholesterolemia or mixed dyslipidemia: Adjunctive therapy to diet for the reduction of low-density lipoprotein cholesterol (LDL-C), total cholesterol (total-C), triglycerides, and apolipoprotein B (apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in adults with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson types IIa and IIb). Use lipid-altering agents in addition to a diet restricted in saturated fat and cholesterol when response to diet and nonpharmacological interventions alone has been inadequate.
Note: While FDA-approved for hypercholesterolemia, Lipo Red is not a first- or second-line choice; other agents may be more suitable (ACC/AHA [Stone 2013]). In addition, use is not recommended to lower LDL-C or raise HDL-C in the absence of hypertriglyceridemia.
Hypertriglyceridemia: Adjunctive therapy to diet for treatment of adult patients with severe hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia).
Off Label Uses
Primary biliary cholangitis
Data from a single-center, retrospective cohort study support the use of Lipo Red (in combination with ursodiol) in patients with primary biliary cholangitis (PBC) who have had an incomplete biochemical response to ursodiol monotherapy and showed significant improvement in alkaline phosphatase, a reduction in hepatic decompensation, and transplant-free survival improvement.
Lipo Red description
Each film-coated tablet contains Fenofibrate BP 160 mg. It also contains the following excipients: Pregelatinized starch maize, povidone, sodium lauryl sulphate, microcrystalline cellulose, crospovidone, anhydrous colloidal silica, sodium stearyl fumarate, purified water and opadry AMB OY-B-28920.
Lipo Red is a lipid-regulating agent. The empirical formula is C20H21O4Cl and the molecular weight is 360.83. Lipo Red is 2-[4-(4-chlorobenzoyl) phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester.
Lipo Red dosage
Lipo Red Dosage
Generic name: Lipo Red 160mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The dose of Lipo Red is 160 mg once daily.
Patients should be placed on an appropriate lipid-lowering diet before receiving Lipo Red and should continue this diet during treatment with Lipo Red.
Lipid levels should be monitored periodically. Therapy should be withdrawn in patients who do not have an adequate response after two months of treatment.
Lipo Red tablets can be given without regard to meals. Patients should be advised to swallow Lipo Red tablets whole. Do not crush, break, dissolve, or chew tablets.
More about Lipo Red (Lipo Red)
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Consumer resources
- Lipo Red
- Lipo Red (Advanced Reading)
- Other brands: Lipo Red, Lofibra, Lipofen, Lipo Red, More (1) »
Professional resources
- Lipo Red (FDA)
- Fenofibric Acid/Lipo Red (AHFS Monograph)
Related treatment guides
- Hyperlipoproteinemia
- Hyperlipoproteinemia Type IIa, Elevated LDL
- Hyperlipoproteinemia Type IIb, Elevated LDL VLDL
- Hyperlipoproteinemia Type IV, Elevated VLDL
- Hyperlipoproteinemia Type V, Elevated Chylomicrons VLDL
- More (1) »
Lipo Red interactions
See also:
What other drugs will affect Lipo Red?
Coumarin Anticoagulants
Potentiation of coumarin-type anticoagulant effect has been observed with prolongation of the PT/INR.
Caution should be exercised when Lipo Red is given in conjunction with coumarin anticoagulants. Lipo Red may potentiate the anticoagulant effect of these agents resulting in prolongation of the PT/INR. To prevent bleeding complications, frequent monitoring of PT/INR and dose adjustment of the oral anticoagulant as recommended until the PT/INR has stabilized.
Immunosuppressants
Immunosuppressant agents such as cyclosporine and tacrolimus can impair renal function and because renal excretion is the primary elimination route of fibrate drugs including Lipo Red capsules, there is a risk that an interaction will lead to deterioration of renal function. When immunosuppressants and other potentially nephrotoxic agents are co-administered with Lipo Red capsules, the lowest effective dose of Lipo Red capsules should be employed and renal function should be monitored.
Bile-Acid Binding Resins
Since bile-acid binding resins may bind other drugs given concurrently, patients should take Lipo Red at least 1 hour before or 4 to 6 hours after a bile acid binding resin to avoid impeding its absorption.
Colchicine
Cases of myopathy, including rhabdomyolysis, have been reported with fenofibrates co-administered with colchicine, and caution should be exercised when prescribing Lipo Red with colchicine.
Lipo Red side effects
See also:
What are the possible side effects of Lipo Red?
Clinical Trials Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Fenofibric acid is the active metabolite of Lipo Red. Adverse events reported by 2% or more of patients treated with Lipo Red and greater than placebo during double-blind, placebocontrolled trials are listed in Table 1. Adverse events led to discontinuation of treatment in 5.0% of patients treated with Lipo Red and in 3.0% treated with placebo. Increases in liver tests were the most frequent events, causing discontinuation of Lipo Red treatment in 1.6% of patients in double-blind trials.
Table 1: Adverse Events Reported by 2% or More of Patients Treated with Lipo Red and Greater than Placebo During the Double-Blind, Placebo-Controlled Trials
BODY SYSTEM Adverse Event | Lipo Red* (N = 439) | Placebo (N = 365) |
BODY AS A WHOLE | ||
Abdominal Pain | 4.6% | 4.4% |
Back Pain | 3.4% | 2.5% |
Headache | 3.2% | 2.7% |
DIGESTIVE | ||
Nausea | 2.3% | 1.9% |
Constipation | 2.1% | 1.4% |
INVESTIGATIONS | ||
Abnormal Liver Tests | 7.5% | 1.4% |
Increased AST | 3.4% | 0.5% |
Increased ALT | 3.0% | 1.6% |
Increased Creatine Phosphokinase | 3.0% | 1.4% |
RESPIRATORY | ||
Respiratory Disorder | 6.2% | 5.5% |
Rhinitis | 2.3% | 1.1% |
* Dosage equivalent to 135 mg Lipo Red |
Clinical trials with Lipo Red did not include a placebo-control arm. However, the adverse event profile of Lipo Red was generally consistent with that of Lipo Red. The following adverse events not listed above were reported in ≥ 3% of patients taking Lipo Red alone:
Gastrointestinal Disorders: Diarrhea, dyspepsia
General Disorders and Administration Site Conditions: Pain
Infections and Infestations: Nasopharyngitis, sinusitis, upper respiratory tract infection
Musculoskeletal and Connective Tissue Disorders: Arthralgia, myalgia, pain in extremity
Nervous System Disorders: Dizzinesss
Postmarketing Experience
The following adverse events have been identified during postapproval use of Lipo Red: rhabdomyolysis, pancreatitis, renal failure, muscle spasms, acute renal failure, hepatitis, cirrhosis, anemia, asthenia, and severely depressed HDL-cholesterol levels.
Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Lipo Red contraindications
See also:
What is the most important information I should know about Lipo Red?
Hypersensitivity to Lipo Red or fenofibric acid or to any of the excipients of Lipo Red.
Severe renal impairment/insufficiency, including those receiving dialysis.
Active liver disease/dysfunction/insufficiency, including those with primary biliary cirrhosis and unexplained persistent liver function abnormalities eg, persistent elevations in serum transaminases. Pre-existing gallbladder disease.
Photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen.
Chronic or acute pancreatitis with the exception of acute pancreatitis due to severe hypertriglyceridemia.
Lipo Red contains lecithin soya as an excipient and therefore, Lipo Red should not be taken with allergic to peanut or arachis oil or soya lecithin, or related products due to the risk of hypersensitivity reactions.
Use in lactation: Lipo Red should not be used in nursing mothers. Because of the potential for tumorigenicity seen in animal studies, a decision should be made whether to discontinue nursing or to discontinue Lipo Red, taking into account the importance of Lipo Red to the mother. There are no data on the excretion of Lipo Red and/or its metabolites into breast milk.
Use in children: Safety and effectiveness in pediatric patients aged <18 years have not been established.
Active ingredient matches for Lipo Red:
Fenofibrate in Spain.
List of Lipo Red substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Lipo Plus C (Argentina) | |
Lipoclar (Italy) | |
Lipofen (Portugal, Turkey, United States) | |
Capsule; Oral; Fenofibrate 100 mg (Nobel) | |
Capsule; Oral; Fenofibrate 150 mg (Nobel) | |
Capsule; Oral; Fenofibrate 50 mg (Nobel) | |
30 capsule in 1 bottle, plastic (Nobel) | |
90 capsule in 1 bottle, plastic (Nobel) | |
Lipofen capsule 150 mg/1 (Nobel) | |
Lipofen capsule 50 mg/1 (Nobel) | |
LIPOFEN SR | |
Lipofen-SR (Turkey) | |
Lipofene (Italy) | |
Lipofib (Romania) | |
Lipohexal (Czech Republic) | |
Lipolex (Egypt) | |
Lipomax 105 (Argentina) | |
Lipomax 35 (Argentina) | |
Lipomin 100 | |
Lipomin 300 | |
Lipoplasmin (Argentina) | |
Lipoprothyl (Taiwan) | |
Lipoprothyl 160 mg | |
Liposyr 100 | |
Liposyr 300 | |
Lipothin (Thailand) | |
Lipothin 200 200 mg x 3 x 10's | |
Lipozor 250 | |
Lipsin (Austria, Italy) | |
Capsule; Oral; Fenofibrate 100 mg (Aventis) | |
Lipsin retard (Austria) | |
Capsule; Oral; Fenofibrate 250 mg | |
Liptuin (Argentina) | |
Lipway (Philippines) | |
Lipway SR 250 mg x 30's (Cathay) | $ 22.00 |
Lipway SR (Philippines) | |
Lipway SR MR cap 250 mg 30's (Cathay Drug) | $ 23.15 |
Livesan (France) | |
Lofat (Bangladesh) | |
Lofibra | |
100 capsule in 1 bottle (Pharos) | |
Lofibra 250 mg x 3 x 10's (Pharos) | $ 25.30 |
Lofibra 200 mg x 50's (Pharos) | $ 22.02 |
Lofibra capsule 200 mg/1 (Pharos) | |
Lofibra tablet, film coated 54 mg/1 (Pharos) | |
Lofibra capsule 67 mg/1 (Pharos) | |
Lofibra tablet, film coated 160 mg/1 (Pharos) | |
Lofibra capsule 134 mg/1 (Pharos) | |
Lofibra Capsules | |
Lopandil (South Korea) | |
See 1103 substitutes for Lipo Red |
References
- DailyMed. "FENOFIBRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "fenofibrate". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "fenofibrate". http://www.drugbank.ca/drugs/DB01039 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lipo Red are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lipo Red. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yet1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Lipo Red drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users | % | ||
---|---|---|---|
Expensive | 1 | 100.0% |
2 consumers reported time for results
To what extent do I have to use Lipo Red before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Lipo Red. To get the time effectiveness of using Lipo Red drug by other patients, please click here.
Users | % | ||
---|---|---|---|
1 month | 2 | 100.0% |
Consumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology