Overdose of Locet in details
Symptoms: SR tab: Headache, nausea, vomiting, epigastric pain, GI irritation and bleeding, rarely diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, occasionally convulsions. In cases of significant poisoning acute renal failure and liver damage are possible.
Gel: The low systemic absorption of topical Locet renders overdosage extremely unlikely. In the event of accidental ingestion, resulting in significant systemic adverse effects, general therapeutic measures normally adopted to treat poisoning with NSAID should be used.
Treatment: Patients should be treated symptomatically as required. Within 1-hr of ingestion of a potentially toxic amount, activated charcoal should be considered. Alternatively, in adults, gastric lavage should be considered within 1-hr of ingestion of a potentially life-threatening overdosage. Good urine output should be ensured. Renal and liver function should be closely monitored. Patients should be observed for at least 4 hrs after ingestion of potentially toxic amounts. In case of frequent or prolonged convulsions, patients should be treated with diazepam IV. Other measures may be indicated by the patient's clinical condition. Specific therapies eg, dialysis or haemoperfusion are probable of no help in eliminating NSAIDs due to their high rate of protein-binding and extensive metabolism. Management of acute poisoning with NSAIDs essentially consists of supportive and symptomatic measures.
Locet warnings
History of GI ulceration; impaired cardiac, renal or hepatic function; hypertension; lactation. IV admin in patients with moderate or severe renal impairment; hypovolaemia or dehydration; asthma, porphyria. Monitor LFTs in patients on prolonged therapy. May prolong bleeding time; caution when used in patients with coagulation disorders or on anticoagulants. Prolonged therapy may increase risk of anaemia. 1st and 2nd trimester of pregnancy. Elderly, debilitated patients.
pregnancy:
Category B(Parenteral): Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Category C(Ophth /
Topical): Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Locet precautions
Locet should be used cautiously in patients with gastrointestinal disorders, with a history of gastrointestinal ulceration, severe impairment of hepatic function, renal or cardiac impairment, patients in recovery after major surgery, the elderly.
Effects on the Ability to Drive or Operate Machinery: Patients suffering from dizziness, vertigo or other central nervous system disorders while taking NSAIDs should refrain from driving or handling dangerous machinery.
Use in pregnancy & lactation: There is no information on the use of Locet during pregnancy and on the secretion of Locet to breast milk.
The use of Locet should therefore be avoided in pregnancy and lactation unless, the potential benefits to the other outweigh the possible risks to the fetus.
Use in children: There are no clinical data on the use of Locet in children and therefore, it is not recommended for use in children.
References
- DailyMed. "CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Aceclofenac". http://www.drugbank.ca/drugs/DB06736 (accessed September 17, 2018).
- DrugBank. "cetirizine". http://www.drugbank.ca/drugs/DB00341 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
