Loperamid SPM Pregnancy

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• Pregnancy of Loperamid SPM in details
• Loperamid SPM breastfeeding
• Loperamid SPM reviews

Pregnancy of Loperamid SPM in details

Adverse effects have not been observed in animal reproduction studies. Information related to Loperamid SPM use in pregnancy is limited and data is conflicting (Einarson 2000; Källén 2008). For acute diarrhea in pregnant women, some clinicians recommend oral rehydration and dietary changes; Loperamid SPM in small amounts may be used only if symptoms are disabling (Wald 2003).

Loperamid SPM breastfeeding

Loperamid SPM is excreted into human milk in small amounts. The effects in the nursing infant are unknown. According to the manufacturer, administration of Loperamid SPM during lactation is not recommended.

In one study, Loperamid SPM was detected in the milk of six healthy puerperal women given Loperamid SPM oxide 4 mg orally every 12 hours for 2 doses. Mean Loperamid SPM milk (serum) concentrations ranged from 0.18 (0.36) ng/mL immediately prior to the second dose to 0.27 (0.73) ng/mL and 0.19 (0.54) ng/mL six and 24 hours after the second dose, respectively. The authors estimated that if an infant drank 165 mL/kg/day, the ingested dose of Loperamid SPM would be 2000 times less than the usual therapeutic dose of 0.2 mg/kg/day. The infants did not breast-feed in this study.

See references

References for pregnancy information

1. "Product Information. Imodium (Loperamid SPM)." Janssen Pharmaceutica, Titusville, NJ.

References for breastfeeding information

1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
2. Nikodem VC, Hofmeyr GJ "Secretion of the antidiarrhoeal agent Loperamid SPM oxide in breast milk." Eur J Clin Pharmacol 42 (1992): 695-6

References

1. PubMed Health. "Loperamide (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
2. Human Metabolome Database (HMDB). "Loperamide: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology