• Dosage of Losartan + Hidroclorotiazida Aurobindo in details
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Dosage of Losartan + Hidroclorotiazida Aurobindo in details

Losartan + Hidroclorotiazida Aurobindo Dosage

Generic name: Losartan (Losartan + Hidroclorotiazida Aurobindo) potassium 50mg, Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) 12.5mg

Dosage form: tablet, film coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Hypertension

The usual starting dose of Losartan + Hidroclorotiazida Aurobindo is 50/12.5 (Losartan (Losartan + Hidroclorotiazida Aurobindo) 50 mg/Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) 12.5 mg) once daily. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (Losartan (Losartan + Hidroclorotiazida Aurobindo) 100 mg/Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) 25 mg) once daily as needed to control blood pressure.

Initiate a patient whose blood pressure is not adequately controlled with Losartan (Losartan + Hidroclorotiazida Aurobindo) 50 mg monotherapy with Losartan + Hidroclorotiazida Aurobindo 50/12.5 once daily. If blood pressure remains uncontrolled after about 3 weeks of therapy, the dosage may be increased to two tablets of Losartan + Hidroclorotiazida Aurobindo 50/12.5 once daily or one tablet of Losartan + Hidroclorotiazida Aurobindo 100/25 once daily.

Initiate a patient whose blood pressure is not adequately controlled with Losartan (Losartan + Hidroclorotiazida Aurobindo) 100 mg monotherapy with Losartan + Hidroclorotiazida Aurobindo 100/12.5 (Losartan (Losartan + Hidroclorotiazida Aurobindo) 100 mg/Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) 12.5 mg) once daily. If blood pressure remains uncontrolled after about 3 weeks of therapy, increase the dose to two tablets of Losartan + Hidroclorotiazida Aurobindo 50/12.5 once daily or one tablet of Losartan + Hidroclorotiazida Aurobindo 100/25 once daily.

Initiate a patient whose blood pressure is inadequately controlled with Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) 25 mg once daily, or is controlled but who experiences hypokalemia with this regimen, on Losartan + Hidroclorotiazida Aurobindo 50/12.5 once daily, reducing the dose of Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) without reducing the overall expected antihypertensive response. Evaluate the clinical response to Losartan + Hidroclorotiazida Aurobindo 50/12.5 and, if blood pressure remains uncontrolled after about 3 weeks of therapy, increase the dose to two tablets of Losartan + Hidroclorotiazida Aurobindo 50/12.5 once daily or one tablet of Losartan + Hidroclorotiazida Aurobindo 100/25 once daily.

Hypertensive Patients with Left Ventricular Hypertrophy

In patients whose blood pressure is not adequately controlled on 50 mg Losartan (Losartan + Hidroclorotiazida Aurobindo) potassium, initiate treatment with Losartan + Hidroclorotiazida Aurobindo 50/12.5. If additional blood pressure reduction is needed, increase the dose to Losartan + Hidroclorotiazida Aurobindo 100/12.5, followed by Losartan + Hidroclorotiazida Aurobindo 100/25. For further blood pressure reduction add other antihypertensives.

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What other drugs will affect Losartan + Hidroclorotiazida Aurobindo?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Losartan + Hidroclorotiazida Aurobindo, especially:

• any other blood pressure medications;

• steroids (prednisone and others);

• lithium;

• cholestyramine or colestipol;

• insulin or oral diabetes medicine;

• rifampin;

• a barbiturate--phenobarbital and others;

• any other diuretic or "water pill";

• NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

• a muscle relaxer--baclofen, carisoprodol, cyclobenzaprine, methocarbamol, tizanidine, and others; or

• narcotic medicine--codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and others.

This list is not complete. Other drugs may interact with Losartan + Hidroclorotiazida Aurobindo, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Losartan + Hidroclorotiazida Aurobindo interactions

Agents Increasing Serum Potassium

Coadministration of Losartan (Losartan + Hidroclorotiazida Aurobindo) with other drugs that raise serum potassium levels may result in hyperkalemia. Monitor serum potassium in such patients.

Lithium

Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of angiotensin II receptor antagonists or thiazide diuretics. Monitor lithium levels in patients receiving Losartan + Hidroclorotiazida Aurobindo and lithium.

Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors

Losartan (Losartan + Hidroclorotiazida Aurobindo) Potassium

In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including Losartan (Losartan + Hidroclorotiazida Aurobindo)) may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Losartan (Losartan + Hidroclorotiazida Aurobindo) and NSAID therapy.

The antihypertensive effect of angiotensin II receptor antagonists, including Losartan (Losartan + Hidroclorotiazida Aurobindo), may be attenuated by NSAIDs, including selective COX-2 inhibitors.

Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo)

The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Losartan + Hidroclorotiazida Aurobindo and non-steroidal anti-inflammatory agents including selective COX-2 inhibitors are used concomitantly, observe closely to determine if the desired effect of the diuretic is obtained.

In patients receiving diuretic therapy, coadministration of NSAIDs with angiotensin receptor blockers, including Losartan (Losartan + Hidroclorotiazida Aurobindo), may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo), Losartan (Losartan + Hidroclorotiazida Aurobindo), and NSAID therapy.

Dual Blockade Of The Renin-Angiotensin System (RAS)

Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy.

The Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 mL/min), randomized them to lisinopril or placebo on a background of Losartan (Losartan + Hidroclorotiazida Aurobindo) therapy and followed them for a median of 2.2 years. Patients receiving the combination of Losartan (Losartan + Hidroclorotiazida Aurobindo) and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end-stage renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury compared with the monotherapy group.

Closely monitor blood pressure, renal function, and electrolytes in patients on Losartan + Hidroclorotiazida Aurobindo and other agents that affect the RAS.

Do not coadminister aliskiren with Losartan + Hidroclorotiazida Aurobindo in patients with diabetes. Avoid use of aliskiren with Losartan + Hidroclorotiazida Aurobindo in patients with renal impairment (GFR < 60 mL/min).

The Use Of Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) With Other Drugs

When administered concurrently, the following drugs may interact with thiazide diuretics :

Antidiabetic drugs (oral agents and insulin) — dosage adjustment of the antidiabetic drug may be required.

Cholestyramine and colestipol resins — Absorption of Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. Stagger the dosage of Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) and the resin such that Hydrochlorothiazide (Losartan (Losartan + Hidroclorotiazida Aurobindo) + Hidroclorotiazida Aurobindo) is administered at least 4 hours before or 4 to 6 hours after the administration of the resin.

References

1. DailyMed. "AMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "LOSARTAN POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. FDA/SPL Indexing Data. "JMS50MPO89: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology