The usual starting dose of Losartana Potássica Ranbaxy is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure. A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy).

Pediatric Hypertension

The usual recommended starting dose is 0.7 mg per kg once daily (up to 50 mg total) administered as a tablet or a suspension. Dosage should be adjusted according to blood pressure response. Doses above 1.4 mg per kg (or in excess of 100 mg) daily have not been studied in pediatric patients.

Losartana Potássica Ranbaxy is not recommended in pediatric patients less than 6 years of age or in pediatric patients with estimated glomerular filtration rate less than 30 mL/min/1.73 m2.

Hypertensive Patients with Left Ventricular Hypertrophy

The usual starting dose is 50 mg of Losartana Potássica Ranbaxy once daily. Hydrochlorothiazide 12.5 mg daily should be added and/or the dose of Losartana Potássica Ranbaxy should be increased to 100 mg once daily followed by an increase in hydrochlorothiazide to 25 mg once daily based on blood pressure response.

Nephropathy in Type 2 Diabetic Patients

The usual starting dose is 50 mg once daily. The dose should be increased to 100 mg once daily based on blood pressure response.

Dosage Modifications in Patients with Hepatic Impairment

In patients with mild-to-moderate hepatic impairment the recommended starting dose of Losartana Potássica Ranbaxy is 25 mg once daily. Losartana Potássica Ranbaxy has not been studied in patients with severe hepatic impairment.

Preparation of Suspension (for 200 mL of a 2.5 mg/mL suspension)

Add 10 mL of Purified Water USP to an 8 ounce (240 mL) amber polyethylene terephthalate (PET) bottle containing ten 50 mg Losartana Potássica Ranbaxy tablets. Immediately shake for at least 2 minutes. Let the concentrate stand for 1 hour and then shake for 1 minute to disperse the tablet contents. Separately prepare a 50/50 volumetric mixture of Ora-Plus™ and Ora-Sweet SF™. Add 190 mL of the 50/50 Ora-Plus™/Ora-Sweet SF™ mixture to the tablet and water slurry in the PET bottle and shake for 1 minute to disperse the ingredients. The suspension should be refrigerated at 2-8°C (36-46°F) and can be stored for up to 4 weeks. Shake the suspension prior to each use and return promptly to the refrigerator.

More about Losartana Potássica Ranbaxy (Losartana Potássica Ranbaxy)

Side Effects
During Pregnancy or Breastfeeding
Dosage Information
Drug Images
Drug Interactions
Support Group
Pricing & Coupons
En Espanol
50 Reviews - Add your own review/rating
Generic Availability

Consumer resources

Losartana Potássica Ranbaxy
Losartana Potássica Ranbaxy (Advanced Reading)

Professional resources

Losartana Potássica Ranbaxy (AHFS Monograph)
Losartana Potássica Ranbaxy (FDA)

Related treatment guides

Diabetic Kidney Disease
High Blood Pressure

What other drugs will affect Losartana Potássica Ranbaxy?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Losartana Potássica Ranbaxy, especially:

a diuretic or "water pill";
other blood pressure medications;
lithium;
celecoxib; or
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with Losartana Potássica Ranbaxy, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Losartana Potássica Ranbaxy interactions

sponsored

No significant drug-drug pharmacokinetic interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital. Rifampin, an inducer of drug metabolism, decreased the concentrations of Losartana Potássica Ranbaxy and its active metabolite. In humans, 2 inhibitors of CYP450 3A4 have been studied. Ketoconazole did not affect the conversion of Losartana Potássica Ranbaxy to the active metabolite after IV administration of Losartana Potássica Ranbaxy, and erythromycin had no clinically significant effect after oral administration. Fluconazole, an inhibitor of CYP450 2C9, decreased active metabolite concentration and increased Losartana Potássica Ranbaxy concentration. The pharmacodynamic consequences of concomitant use of Losartana Potássica Ranbaxy and inhibitors of CYP450 2C9 have not been examined. Subjects who do not metaolize Losartana Potássica Ranbaxy to active metabolite have been shown to have a specific, rare defect in CYP450 2C9. These data suggest that the conversion of Losartana Potássica Ranbaxy to its active metabolite is mediated primarily by CYP450 2C9 and not CYP450 3A4.

No difference in exposure was found with concomitant treatment with fluvastatin (weak inhibitor of CYP2C9).

As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), drugs which may increase potassium levels (heparin), potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium. Co-medication is not advisable.

Lithium: As with other drugs which affect the excretion of sodium, lithium excretion may be reduced. Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor antagonists.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Including Selective Cyclooxygenase-2 (COX-2) Inhibitors: In some patients with compromised renal function who are being treated with NSAIDs including those that selectively inhibit COX-2 inhibitors, the co-administration of angiotensin II receptor antagonists including Losartana Potássica Ranbaxy may result to a further deterioration of renal function. These effects are usually reversible.

Reports suggest that NSAIDs including COX-2 inhibitors may diminish the antihypertensive effect of angiotensin II receptor antagonists, including Losartana Potássica Ranbaxy. This interaction should be given consideration in patients taking NSAIDs including selective COX-2 inhibitors concomitantly with angiotensin II receptor antagonists.

The combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy and periodically thereafter.

sponsored

References

DailyMed. "LOSARTAN POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
FDA/SPL Indexing Data. "JMS50MPO89: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Losartana Potássica Ranbaxy are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Losartana Potássica Ranbaxy. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported frequency of use

No survey data has been collected yet

Consumer reported doses

No survey data has been collected yet

Consumer reviews

There are no reviews yet. Be the first to write one!

Information checked by Dr. Sachin Kumar, MD Pharmacology

Losartana Potássica Ranbaxy Dosage

Dosage of Losartana Potássica Ranbaxy in details