Dosage of Lugol in details
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Lugol solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Reconstitution: Administer Lugol oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.
Oral
Grave's disease
Child: Neonates: 1 drop of strong Lugol solution every 8 hr.
Oral
Radiation protection against radioactive Lugol
Adult: As Lugol: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As Lugol: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg Lugol per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg Lugol per 5 ml.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As Lugol solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As Lugol: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Reconstitution: Administer Lugol solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.
Oral
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 400 mg Lugol once yrly. Pregnant patient: 200 mg Lugol as a single dose. Moderate to severe: 300-480 mg Lugol each yr or 100-300 mg Lugol every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Infants up to 1 yr: Single dose of 100 mg Lugol; 1-5 yr: 200 mg Lugol; >6 yr: 400 mg Lugol.
Oral
Thyroid storm
Adult: As Lugol: Up to 500 mg every 4 hr.
Intramuscular
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Up to 45 yr: 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Lugol each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Lugol, as iodised oil (480 mg/ml Lugol).
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
What other drugs will affect Lugol?
Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Lugol interactions
There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.
this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.
Since Lugol may be absorbed systemically, the result of tests of the thyroid function can be influenced.
References
- DailyMed. "AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "POTASSIUM IODIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "RWP5GA015D: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lugol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lugol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yetConsumer reported doses
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Information checked by Dr. Sachin Kumar, MD Pharmacology
