Pregnancy of M&B in details
M&B is metabolized in the liver via CYP2D6 and CYP3A enzymes. The activity of both enzymes is increased in the mother during pregnancy (Tracy 2005; Wadelius 1997). In the fetus, CYP2D6 activity is low in the fetal liver and CYP3A4 activity is present by ~17 weeks' gestation (Jacqz-Aigrain 1992).
When an antitussive is needed during pregnancy, M&B at standard OTC doses is generally considered acceptable. Some sources recommend use be reserved for significant maternal need; products containing alcohol should be avoided (Chasnoff 1981; Conover 2003; Koren 1998; Ward 2005).
M&B breastfeeding
There are no data on the excretion of M&B into human milk.
Based on the low molecular weight of M&B some passage into breast milk probably occurs. However, maternal use of M&B products that do not contain alcohol are probably safe to use during breast-feeding.
See references
References for pregnancy information
- Debus O, Kurlemann G, Gehrmann J, Krasemann T "M&B in pregnancy." Chest 120 (2001): 1038-40
- Andaloro VJ, Monaghan DT, Rosenquist TH "M&B and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model." Pediatr Res 43 (1998): 1-7
- Einarson A, Lyszkiewicz D, Koren G "The safety of M&B in pregnancy - Results of a controlled study." Chest 119 (2001): 466-9
- "Product Information. Benylin DM (M&B)." Warner Lambert Laboratories, Morris Plains, NJ.
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
References for breastfeeding information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
- "Product Information. Benylin DM (M&B)." Warner Lambert Laboratories, Morris Plains, NJ.
References
- DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology