Consists of Benserazide, Levodopa
Pregnancy of Levodopa (Madopar HBS 125) in details
Levodopa (Madopar HBS 125) has not been formally assigned to a pregnancy category. However, some of the commercially available formulations of Levodopa (Madopar HBS 125)-carbidopa have been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of visceral and skeletal malformations in rabbits at doses 5 to 20 times the maximum recommended human dose of Levodopa (Madopar HBS 125)-carbidopa. There are no controlled data in human pregnancy. Two reports have described three patients who received Levodopa (Madopar HBS 125) or Levodopa (Madopar HBS 125)-carbidopa throughout pregnancy without evidence of fetal harm. Levodopa (Madopar HBS 125) should only be given in human pregnancy when benefit outweighs risk.
One study has reported that single oral doses of Levodopa (Madopar HBS 125) administered to pregnant women result in decreased plasma renin activity, decreased plasma aldosterone and decreased plasma prolactin.
See references
Levodopa (Madopar HBS 125) breastfeeding
There are no data on the excretion of Levodopa (Madopar HBS 125) into human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- "Product Information. Sinemet CR (carbidopa-Levodopa (Madopar HBS 125))." Dupont Pharmaceuticals, Wilmington, DE.
- "Product Information. Sinemet (carbidopa-Levodopa (Madopar HBS 125))." DuPont Pharmaceuticals, Wilmington, DE.
References for breastfeeding information
- "Product Information. Larodopa (Levodopa (Madopar HBS 125))." Roche Laboratories, Nutley, NJ.
References
- DailyMed. "CARBIDOPA; ENTACAPONE; LEVODOPA: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Levodopa (Oral route): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "L-Dopa: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
