How should I take Manganese?
Dosing
The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (as part of a multivitamin/mineral supplement):
- To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
- Adults and teenagers—2 to 5 milligrams (mg) per day.
- Children 7 to 10 years of age—2 to 3 mg per day.
- Children 4 to 6 years of age—1.5 to 2 mg per day.
- Children birth to 3 years of age—0.3 to 1.5 mg per day.
- To treat deficiency:
- Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency.
- To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss taking manganese supplements for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in manganese. However, if your health care professional has recommended that you take manganese, try to remember to take it as directed every day.
Storage
Keep out of the reach of children.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Do not keep outdated medicine or medicine no longer needed.
Manganese administration
Capsule, tablet: May be administered with a meal.
Solution for injection: Do not administer IM or by direct IV injection; acidic pH of the solution may cause tissue irritations and it is hypotonic; administer after dilution in volume of fluid ≥100 mL
Manganese pharmacology
Manganese is an essential nutrient which serves as an activator for enzymes such as polysaccharide polymerase, liver arginase, cholinesterase and pyruvate carboxylase. Providing Manganese during TPN helps prevent development of deficiency symptoms such as nausea and vomiting, weight loss, dermatitis and changes in growth and color of hair.
Under conditions of minimal intake, 20 mcg Manganese/day is retained. Manganese is bound to a specific transport protein, transmanganin, a beta-l-globulin. Manganese is widely distributed but concentrates in the mitochondria rich tissues such as brain, kidney, pancreas, and liver. Assays for Manganese in whole blood result in concentrations ranging from 6 to 12 mcg/Manganese/liter.
Excretion of Manganese occurs mainly through the bile, but in the event of obstruction, ancillary excretion routes include pancreatic juice, or return into the lumen of the duodenum, jejunum, or ileum. Urinary excretion of Manganese is negligible.
References
- EPA Air Toxics. "Manganese compounds: EPA Health Effects Notebook for Hazardous Air Pollutants". https://www.epa.gov/sites/production... (accessed September 17, 2018).
- EPA Chemicals under the TSCA. "Manganese: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
- USGS National Minerals Informati. "Manganese: The USGS Minerals Yearbook is an annual publication that reviews the mineral and material industries. The information collected is from the Volume I of the Yearbook for approximately 90 commodities. ". https://minerals.usgs.gov/minerals/p... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Manganese are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Manganese. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
