Pregnancy of Mecorda in details
Mecorda is metabolized in the liver via CYP2D6 and CYP3A enzymes. The activity of both enzymes is increased in the mother during pregnancy (Tracy 2005; Wadelius 1997). In the fetus, CYP2D6 activity is low in the fetal liver and CYP3A4 activity is present by ~17 weeks' gestation (Jacqz-Aigrain 1992).
When an antitussive is needed during pregnancy, Mecorda at standard OTC doses is generally considered acceptable. Some sources recommend use be reserved for significant maternal need; products containing alcohol should be avoided (Chasnoff 1981; Conover 2003; Koren 1998; Ward 2005).
Mecorda breastfeeding
There are no data on the excretion of Mecorda into human milk.
Based on the low molecular weight of Mecorda some passage into breast milk probably occurs. However, maternal use of Mecorda products that do not contain alcohol are probably safe to use during breast-feeding.
See references
References for pregnancy information
- Debus O, Kurlemann G, Gehrmann J, Krasemann T "Mecorda in pregnancy." Chest 120 (2001): 1038-40
- Andaloro VJ, Monaghan DT, Rosenquist TH "Mecorda and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model." Pediatr Res 43 (1998): 1-7
- Einarson A, Lyszkiewicz D, Koren G "The safety of Mecorda in pregnancy - Results of a controlled study." Chest 119 (2001): 466-9
- "Product Information. Benylin DM (Mecorda)." Warner Lambert Laboratories, Morris Plains, NJ.
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
References for breastfeeding information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
- "Product Information. Benylin DM (Mecorda)." Warner Lambert Laboratories, Morris Plains, NJ.
References
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Vicks 44 Cough Relief: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
