What is Mefenamin Pfizer?
Mefenamin Pfizer is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Mefenamin Pfizer works by reducing hormones that cause inflammation and pain in the body.
Mefenamin Pfizer is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.
Mefenamin Pfizer may also be used for other purposes not listed in this medication guide.
Mefenamin Pfizer indications
Carefully consider the potential benefits and risks of Mefenamin Pfizer (Mefenamin Pfizer) and other treatment options before deciding to use Mefenamin Pfizer (Mefenamin Pfizer). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Mefenamin Pfizer (Mefenamin Pfizer) is indicated:
- For relief of mild to moderate pain in patients =14 years of age, when therapy will not exceed one week (7 days).
- For treatment of primary dysmenorrhea.
How should I use Mefenamin Pfizer?
Use Mefenamin Pfizer as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Mefenamin Pfizer comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Mefenamin Pfizer refilled.
- Take Mefenamin Pfizer by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Take Mefenamin Pfizer with a full glass of water (8 oz/240 mL) as directed by your doctor.
- If you miss a dose of Mefenamin Pfizer and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Mefenamin Pfizer.
Uses of Mefenamin Pfizer in details
Use: Labeled Indications
Pain, mild to moderate: Relief of mild to moderate pain in patients ≥14 years, when therapy will not exceed 1 week.
Primary dysmenorrhea: Treatment of primary dysmenorrhea.
Mefenamin Pfizer description
Mefenamin Pfizer (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Mefenamin Pfizer's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Mefenamin Pfizer cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Mefenamin Pfizer is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products.
Mefenamin Pfizer dosage
Carefully consider the potential benefits and risks of Mefenamin Pfizer (Mefenamin Pfizer) and other treatment options before deciding to use Mefenamin Pfizer (Mefenamin Pfizer). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Mefenamin Pfizer (Mefenamin Pfizer), the dose and frequency should be adjusted to suit an individual patient's needs.
For the relief of acute pain in adults and adolescents =14 years of age, the recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours as needed, usually not to exceed one week.
How supplied
Mefenamin Pfizer (Mefenamin Pfizer) is available as 250 mg blue-banded, ivory capsules, imprinted with "FHPC 400" and "Mefenamin Pfizer® (Mefenamin Pfizer) ".
Bottles of 100...................NDC 59630-400-10
Storage
Store at 20- 25°C (68- 77°F); excursions permitted to 15-30°C (59-86°F).
REFERENCES
4. Glazko AJ: Experimental observations of flufenamic, mefenamic, and meclofenamic acids. Part III. Metabolic disposition, in Fenamates in Medicine. A Symposium, London, 1966. Annals of Physical Medicine, Supplement, pp 23-36, 1967.
5. Data on file, First Horizon (Protocol 356).
Distributed by: Atlanta, GA 30328. Revised March 2007. FDA Rev date: 3/6/2008
Mefenamin Pfizer interactions
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What other drugs will affect Mefenamin Pfizer?
A number of compounds are inhibitors of CYP2C9. Drug interactions studies of Mefenamin Pfizer and these compounds have not been conducted. The possibility of altered safety and efficacy should be considered when Mefenamin Pfizer (Mefenamin Pfizer) is used concomitantly with these drugs.
ACE-inhibitors
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Aspirin
When Mefenamin Pfizer (Mefenamin Pfizer) is administered with aspirin, its protein binding is reduced, although the clearance of free Mefenamin Pfizer (Mefenamin Pfizer) is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Mefenamin Pfizer and aspirin is not generally recommended because of the potential of increased adverse effects.
Diuretics
Clinical studies, as well as post marketing observations, have shown that Mefenamin Pfizer (Mefenamin Pfizer) can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy of NSAIDs, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.
Lithium
NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin
The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
Antacids
In a single dose study (n=6), ingestion of an antacid containing 1.7-gram of magnesium hydroxide with 500-mg of Mefenamin Pfizer increased the Cmax and AUC of Mefenamin Pfizer by 125% and 36%, respectively. Therefore, when the drug is administered to patients receiving oral anticoagulant drugs, frequent monitoring of prothrombin time is necessary.
A false-positive reaction for urinary bile, using the diazo tablet test, may result after Mefenamin Pfizer administration. If biliuria is suspected, other diagnostic procedures, such as the Harrison spot test, should be performed.
REFERENCES
4. Glazko AJ: Experimental observations of flufenamic, mefenamic, and meclofenamic acids. Part III. Metabolic disposition, in Fenamates in Medicine. A Symposium, London, 1966. Annals of Physical Medicine, Supplement, pp 23-36, 1967.
Mefenamin Pfizer side effects
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What are the possible side effects of Mefenamin Pfizer?
Diarrhoea occasionally occurs following the use of Mefenamin Pfizer. Although this may occur soon after starting of treatment, it may also occur after several months of continuous use. The diarrhoea has been investigated in some patients who have continued this drug in spite of its continued presence; these patients were found to have associated proctocolitis.
If diarrhoea does develop; the drug should be discontinued immediately and the patient should not receive Mefenamin Pfizer again.
Skin rashes have been observed following the administration of Mefenamin Pfizer and the occurrence of a rash is a definite indication to stop medication.
As with other prostaglandin inhibitors, allergic glomerulonephritis has occurred occasionally.
Rarely, thrombocytopenia has been reported with Mefenamin Pfizer. In some cases reversible haemolytic anaemia has occurred with continuous administration of Mefenamin Pfizer for 12 months or longer.
Temporary lowering of the white blood cells count has been reported. Blood studies should therefore be carried out during long term administration.
Bronchospasm may be precipitated in patients suffering from, or with a previous history of bronchial asthma or allergic disease.
Patients on prolonged therapy should also be kept under surveillance with particular attention to liver dysfunction; should this appear, it is an indication to discontinue therapy.
Drowsiness and dizziness have rarely been reported.
Mefenamin Pfizer contraindications
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What is the most important information I should know about Mefenamin Pfizer?
Mefenamin Pfizer (Mefenamin Pfizer) is contraindicated in patients with known hypersensitivity to Mefenamin Pfizer.
Mefenamin Pfizer (Mefenamin Pfizer) should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Mefenamin Pfizer (Mefenamin Pfizer) is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Mefenamin Pfizer (Mefenamin Pfizer) is contraindicated in patients with acute active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract.
Mefenamin Pfizer (Mefenamin Pfizer) should not be used in patients with preexisting renal disease.
Active ingredient matches for Mefenamin Pfizer:
Mefenamic Acid in Switzerland.
List of Mefenamin Pfizer substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Mefenamin-Teva (Switzerland) | |
| Mefenaminacid-Cimex (Switzerland) | |
| Tablet, Film-Coated; Oral; Mefenamic Acid 500 mg | |
| Mefenaminsaeure | |
| Mefenaminsaure | |
| Capsule; Oral; Mefenamic Acid 250 mg | |
| Suppositories; Rectal; Mefenamic Acid 125 mg | |
| Suppositories; Rectal; Mefenamic Acid 500 mg | |
| Tablet, Film-Coated; Oral; Mefenamic Acid 500 mg | |
| Mefenaminsäure Sandoz (Switzerland) | |
| Mefenaminsaure Sandoz 500mg (Switzerland) | |
| Mefenan (Myanmar, Thailand) | |
| Mefenan 250 mg x 10's (Greater pharma) | |
| Mefenan 250 mg x 50 x 10's (Greater pharma) | |
| Mefenan 250 mg x 1, 000's (Greater pharma) | |
| Mefenan 500 mg x 500's (Greater pharma) | |
| Mefenax (Philippines) | |
| Mefenax 500 mg x 100's (One Pharma) | $ 19.56 |
| Mefenax tab 500 mg 100's (One Pharma) | $ 19.56 |
| Mefenix (Singapore) | |
| Mefenix 250 mg x 1000's (Phoenix) | |
| Mefenix 250 mg x 10 Blister x 10 Tablet (Phoenix) | |
| Mefentan (Egypt) | |
| Mefentin (Taiwan) | |
| Mefentin 250 mg | |
| Mefentin 250 mg x Blister pk | |
| Mefepain (Bangladesh) | |
| Mefeton (Taiwan) | |
| Mefeton 500 mg | |
| Mefeton 500 mg x 84's | |
| Meff-P | |
| Meff-P 100mg Tablet (BestoChem Formulations India Ltd) | $ 0.01 |
| Mefgesic (Pakistan) | |
| MEFGUN SUSP (India) | |
| MEFGUN SUSP susp / oral use 100 mg x 60ml (Haledew) | |
| Mefic (Hong Kong, Malaysia, Taiwan) | |
| Capsule; Oral; Mefenamic Acid 250 mg (Alphapharm) | |
| Mefic 250 mg x 1, 000's (Alphapharm) | $ 150.00 |
| Mefic 250 mg (Alphapharm) | |
| Mefidol 250 | |
| Mefidol 50 | |
| Mefidol 500 | |
| Mefinal (Indonesia) | |
| Mefinal 250 mg x 10 x 10's (Sanbe) | $ 5.70 |
| Mefinal 500 mg x 10 x 10's (Sanbe) | $ 12.71 |
| Mefinter (Indonesia) | |
| Mefinter 250 mg x 10 x 10's (Interbat) | $ 4.96 |
| Mefinter 500 mg x 10 x 10's (Interbat) | $ 9.67 |
| Mefix (Indonesia) | |
| MEFKIND P | |
| MEFKIND-P SUSPENSION 1 bottle / 60 ML suspension each (Mankind Pharma Ltd) | $ 0.36 |
| Meflaxin (India) | |
| Meflaxin Mefenamic Acid 250mg, Dicylomine HCI 10mg TAB / 10 (Acto) | $ 0.29 |
| 10's (Acto) | $ 0.29 |
| Meflaxin Mefenamic acid 250 mg, Dicyclomine hydrochloride 10mg. TAB / 10 (Acto) | $ 0.29 |
See 1276 substitutes for Mefenamin Pfizer | |
References
- DailyMed. "MEFENAMIC ACID: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "mefenamic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "mefenamic acid". http://www.drugbank.ca/drugs/DB00784 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Mefenamin Pfizer are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Mefenamin Pfizer. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
