Overdose of Megacillin in details
Symptoms: Nausea, vomiting, stomach pain, diarrhoea, and rarely, major motor seizures. If other symptoms are present, consider the possibility of an allergic reaction. Hyperkalaemia may result, particularly for patients w/ renal insufficiency. Management: Symptomatic and supportive treatment. May admin activated charcoal w/ a cathartic, e.g. sorbitol to hasten drug elimination. May be removed by haemodialysis.
Megacillin warnings
Megacillin potassium is an antibiotic used to treat a variety of infections, most notably strep throat. This drug is also used to prevent infections (bacterial endocarditis) in patients with congenital heart disease or rheumatic or other acquired valvular heart disease. Penicillin is taken before dental procedures and surgical procedures in these patients. This drug should not be used by those with allergies to penicillin and you should consult with your pharmacist or physician if you are allergic to penicillin before taking this medication. The most common side effects from penicillin include: nausea, vomiting, epigastric distress, and diarrhea. Because this medication is used to treat infections, it should be taken as prescribed. Even if your symptoms are better, the entire supply of medication should be taken to ensure the infection is cured. Liquid forms of penicillin must be refrigerated and shaken before administered.
Megacillin precautions
Careful inquiry should be made concerning previous hypersensitivity to penicillins prior to initiation of penicillin V therapy.
Reduce dosage in patients with impaired renal function.
Superinfections with fungal or bacterial pathogens may develop with prolonged or repeated use. Use in pregnancy: Safe use of penicillin V during pregnancy has not been definitely established.
Use in lactation: Penicillin V is excreted in milk. Use of the drug by nursing mothers may lead to sensitization of infants; therefore, a decision should be made whether to discontinue nursing or discontinue penicillin V, taking into account the importance of the drug to the mother.
References
- DailyMed. "PENICILLIN G SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Tazobactam". http://www.drugbank.ca/drugs/DB01606 (accessed September 17, 2018).
- DrugBank. "penicillin g". http://www.drugbank.ca/drugs/DB01053 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
