What happens if I overdose Minims Saline?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Minims Saline nebulizer solution may be harmful if swallowed.
Proper storage of Minims Saline nebulizer solution:
Store Minims Saline nebulizer solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not use the solution if it is discolored or contains particles. Store ampules in foil pouch until ready for use. Keep Minims Saline nebulizer solution out of the reach of children and away from pets.
Overdose of Minims Saline in details
Excessive administration of 0.45% Minims Saline Injection, USP may lead to hypo- and hypernatremia, while excessive administration of 0.9% Minims Saline Injection, USP may lead to hypernatremia. Both hypo- and hypernatremia can lead to CNS manifestations, including seizures, coma, cerebral edema and death.
Excessive administration of Minims Saline Injection, USP may lead to sodium overload (which can lead to central and/or peripheral edema).
When assessing an overdose, any additives in the solution must also be considered. The effects of an overdose may require immediate medical attention and treatment.
What should I avoid while taking Minims Saline?
Avoid getting Minims Saline in your eyes.
Avoid sharing nasal products with other people. Sharing a nasal spray container or applicator that is inserted into the nose can allow infections or disease to pass from one person to another.
Minims Saline warnings
Hypersensitivity/infusion reactions, including hypotension, pyrexia, tremor, chills, urticaria, rash, and pruritus have been reported with 0.9% Minims Saline Injection, USP and may occur with 0.45% Minims Saline Injection, USP.
Stop the infusion immediately if signs or symptoms of a hypersensitivity reaction develop, such as tachycardia, chest pain, dyspnea and flushing. Appropriate therapeutic countermeasures must be instituted as clinically indicated.
Depending on the volume and rate of infusion, the intravenous administration of Minims Saline Injection, USP can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration/hypervolemia, congested states, pulmonary edema, or acid-base imbalance. The risk of dilutive states is inversely proportional to the electrolyte concentration of the injection. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injection.
Monitor changes in fluid balance, electrolyte concentrations, and acid base balance during prolonged parenteral therapy or whenever the condition of the patient or the rate of administration warrants such evaluation.
Administer 0.9% Minims Saline Injection, USP with particular caution, to patients with or at risk for hypernatremia, hyperchloremia, or metabolic acidosis.
The infusion of solutions with 0.45% Minims Saline Injection, USP may result in hyponatremia. Close clinical monitoring may be warranted. Hyponatremia can lead to headache, nausea, seizures, lethargy, coma, cerebral edema and death. The risk for hyponatremia is increased, for example, in children, elderly, women, postoperatively, in persons with psychogenic polydipsia, and in patients treated with medications that increase the risk of hyponatremia (such as certain antiepileptic and psychotropic medications). The risk for developing hyponatremic encephalopathy is increased, for example, in pediatric patients (≤16 years of age), women (in particular pre-menopausal women), in patients with hypoxemia, and in patients with underlying central nervous system disease. Acute symptomatic hyponatremic encephalopathy is considered a medical emergency.
Administer Minims Saline Injection, USP with particular caution, to patients with or at risk for hypervolemia or with conditions that may cause sodium retention, fluid overload and edema; such as patients with primary hyperaldosteronism, or secondary hyperaldosteronism [e.g., associated with hypertension, congestive heart failure, liver disease (including cirrhosis), renal disease (including renal artery stenosis, nephrosclerosis) or pre-eclampsia]. Certain medications may increase risk of sodium and fluid retention, see Drug Interactions.
Administer Minims Saline Injection, USP with particular caution, to patients with severe renal impairment. In such patients, administration of Minims Saline Injection, USP may result in sodium retention.
What should I discuss with my healthcare provider before taking Minims Saline?
Some medical conditions may interact with Minims Saline solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have congestive heart failure or other heart problems, kidney or liver problems, swelling with or without sodium retention, high blood volume, high blood potassium or sodium levels, a damaged urinary tract, or circulation problems
Some MEDICINES MAY INTERACT with Minims Saline solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Corticosteroids (eg, prednisone) or corticotropin because the risk of side effects of Minims Saline solution may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Minims Saline solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Minims Saline precautions
General
Do not connect flexible plastic containers of intravenous solutions in series connections. Such use could result in air embolism due to residual air being drawn from one container before administration of the fluid from a secondary container is completed. Pressurizing intravenous solutions contained in flexible plastic containers to increase flow rates can result in air embolism if the residual air in the container is not fully evacuated prior to administration.
Use of a vented intravenous administration set with the vent in the open position could result in air embolism. Vented intravenous administration sets with the vent in the open position should not be used with flexible plastic containers.
Laboratory Tests
Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentrations, and acid base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation.
Carcinogenesis and Mutagenesis and Impairment of Fertility
Studies with Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP have not been performed to evaluate carcinogenic potential, mutagenic potential, or effects on fertility.
Pregnancy
Teratogenic Effects
Pregnancy Category C
Animal reproduction studies have not been conducted with Minims Saline Injection, USP. It is also not known whether Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP should be given to a pregnant woman only if clearly needed.
Labor and Delivery
Studies have not been conducted to evaluate the effects of Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP on labor and delivery. Caution should be exercised when administering this drug during labor and delivery.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP is administered to a nursing woman.
Pediatric Use
Safety and effectiveness of Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP in pediatric patients have not been established by adequate and well controlled trials, however, the use of Minims Saline (Minims Saline (Minims Saline injection) injection) solutions in the pediatric population is referenced in the medical literature. The warnings, precautions and adverse reactions identified in the label copy should be observed in the pediatric population.
Geriatric Use
Clinical studies of Minims Saline (Minims Saline (Minims Saline injection) injection) Injection, USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in the responses between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or drug therapy.
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
What happens if I miss a dose of Minims Saline?
Since Minims Saline inhalation is sometimes used only as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
References
- DailyMed. "AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Sodium Chloride". http://www.drugbank.ca/drugs/DB09153 (accessed September 17, 2018).
- MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
