Dosage of Minocycline Hydrochloride in details
The recommended dosage of Minocycline Hydrochloride extended-release tablet USP is approximately 1 mg/kg once daily for 12 weeks. Higher doses have not shown to be of additional benefit in the treatment of inflammatory lesions of acne, and may be associated with more acute vestibular side effects.
The following table shows tablet strength and body weight to achieve approximately 1 mg/kg.
| Patient's Weight (lbs.) | Patient's Weight (kg) | Tablet Strength (mg) | Actual mg/kg Dose |
| 99 - 109 | 45 - 49 | 45 | 1 - 0.92 |
| 110 - 131 | 50 - 59 | 55 | 1.10 - 0.93 |
| 132 - 157 | 60 - 71 | 65 | 1.08 - 0.92 |
| 158 - 186 | 72 - 84 | 80 | 1.11 - 0.95 |
| 187 - 212 | 85 - 96 | 90 | 1.06 - 0.94 |
| 213 - 243 | 97 - 110 | 105 | 1.08 - 0.95 |
| 244 - 276 | 111 - 125 | 115 | 1.04 - 0.92 |
| 277 - 300 | 126 - 136 | 135 | 1.07 - 0.99 |
Minocycline Hydrochloride extended-release tablets USP may be taken with or without food. Ingestion of food along with Minocycline Hydrochloride extended-release tablets USP may help reduce the risk of esophageal irritation and ulceration.
In patients with renal impairment, the total dosage should be decreased by either reducing the recommended individual doses and/or by extending the time intervals between doses.
What other drugs will affect Minocycline Hydrochloride?
Tell your doctor about all other medicines you use, especially:
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other antibiotics;
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acetaminophen (Tylenol);
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isotretinoin (Accutane, Amnesteem, Claravis, Sotret);
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methotrexate (Rheumatrex, Trexall);
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antifungal medicine such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend);
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a blood thinner such as warfarin (Coumadin, Jantoven);
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cholesterol medications such as niacin (Advicor, Niaspan, Niacor, Simcor, Slo Niacin, and others), atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);
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heart or blood pressure medicine such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
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migraine headache medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine); or
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an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others.
This list is not complete and other drugs may interact with Minocycline Hydrochloride. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Minocycline Hydrochloride interactions
Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.
Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.
The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.
Administration of isotretinoin should be avoided shortly before, during, and shortly after Minocycline Hydrochloride therapy. Each drug alone has been associated with pseudotumor cerebri.
Increased risk of ergotism when ergot alkaloids or their derivatives are given with tetracyclines.
References
- FDA/SPL Indexing Data. "FYY3R43WGO: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "(4S,4aS,5aR,12aS,Z)-2-[amino(hidroxi)metilene]-4,7-bis(dimetilamino)-10,11,12a-trihidroxi-4a,5,5a,6-tetrahidrotetracene-1,3,12(2H,4H,12aH)-triona: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Minocycline Hydrochloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Minocycline Hydrochloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yet1 consumer reported doses
What doses of Minocycline Hydrochloride drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Minocycline Hydrochloride drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 51-100mg | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
