Pregnancy of Mit S CODEINE in details
Chlorpheniramine (Mit S Codeine (Mit S CODEINE))-Codeine (Mit S CODEINE) has been assigned to pregnancy category C by the manufacturer. Codeine (Mit S CODEINE) has been assigned to pregnancy category C by the FDA. Codeine (Mit S CODEINE) has shown a statistically significant association with teratogenicity (involving respiratory tract malformations). Like other narcotics, Codeine (Mit S CODEINE) rapidly crosses the placenta. Neonatal Codeine (Mit S CODEINE) withdrawal has occurred even in infants whose mothers were taking Codeine (Mit S CODEINE) at cough suppressant doses for as little as ten days prior to delivery. There are no controlled data in human pregnancy. Chlorpheniramine (Mit S Codeine (Mit S CODEINE))-Codeine (Mit S CODEINE) is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
Mit S CODEINE breastfeeding
Chlorpheniramine (Mit S Codeine (Mit S CODEINE)) is excreted into human milk. The clinical significance is unknown, however, the anticholinergic action of Chlorpheniramine (Mit S Codeine (Mit S CODEINE)) may suppress lactation if taken prior to nursing. Codeine (Mit S CODEINE) is excreted into human milk in small amounts. The FDA issued a Public Health Advisory about a very rare, but serious, side effect in nursing infants whose mothers are taking Codeine (Mit S CODEINE) and are ultra-rapid metabolizers of Codeine (Mit S CODEINE). Several small series and one small retrospective study suggest that Codeine (Mit S CODEINE) may be causative in episodes of apnea, bradycardia, and cyanosis in the first week of life. Codeine (Mit S CODEINE) is nevertheless considered compatible with breast-feeding by the American Academy of Pediatrics. The manufacturer recommends that caution be used when administering Chlorpheniramine (Mit S Codeine (Mit S CODEINE))-Codeine (Mit S CODEINE) is nursing women.
The FDA issued a Public Health Advisory regarding a very rare, but serious, side effect. This may occur in nursing infants whose mothers are taking Codeine (Mit S CODEINE) and are ultra-rapid metabolizers of Codeine (Mit S CODEINE). When Codeine (Mit S CODEINE) enters the body and is metabolized, it changes to morphine, which relieves pain. Many factors affect Codeine (Mit S CODEINE) metabolism, including a person's genetic make-up. Some people have a variation in a liver enzyme and may change Codeine (Mit S CODEINE) to morphine more rapidly and completely than other people. Nursing mothers taking Codeine (Mit S CODEINE) may also have higher morphine levels in their breast milk. These higher levels of morphine in breast milk may lead to life-threatening or fatal side effects in nursing babies. In most cases, it is not known if someone is an ultra-rapid metabolizer of Codeine (Mit S CODEINE). When prescribing Codeine (Mit S CODEINE)-containing drugs to nursing mothers, it is recommended that the lowest effective dose be used for the shortest period of time. It is also recommended that the mother-infant pairs be closely monitored. There is an FDA cleared test for determining a patient's CYP450 2D6 genotype. The test is not routinely used in clinical practice but is available through a number of different laboratories. The results of this test predict that a person can convert Codeine (Mit S CODEINE) to morphine at a faster rate than average, resulting in higher morphine levels in the blood. When levels of morphine are too high, patients have an increased risk of adverse events.
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CODEINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Codeine (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
