Mlm-Dex Pregnancy

• Pregnancy of Mlm-Dex in details
• Mlm-Dex breastfeeding
• Mlm-Dex reviews

Pregnancy of Mlm-Dex in details

Mlm-Dex is metabolized in the liver via CYP2D6 and CYP3A enzymes. The activity of both enzymes is increased in the mother during pregnancy (Tracy 2005; Wadelius 1997). In the fetus, CYP2D6 activity is low in the fetal liver and CYP3A4 activity is present by ~17 weeks' gestation (Jacqz-Aigrain 1992).

When an antitussive is needed during pregnancy, Mlm-Dex at standard OTC doses is generally considered acceptable. Some sources recommend use be reserved for significant maternal need; products containing alcohol should be avoided (Chasnoff 1981; Conover 2003; Koren 1998; Ward 2005).

Mlm-Dex breastfeeding

There are no data on the excretion of Mlm-Dex into human milk.

Based on the low molecular weight of Mlm-Dex some passage into breast milk probably occurs. However, maternal use of Mlm-Dex products that do not contain alcohol are probably safe to use during breast-feeding.

See references

References for pregnancy information

1. Debus O, Kurlemann G, Gehrmann J, Krasemann T "Mlm-Dex in pregnancy." Chest 120 (2001): 1038-40
2. Andaloro VJ, Monaghan DT, Rosenquist TH "Mlm-Dex and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model." Pediatr Res 43 (1998): 1-7
3. Einarson A, Lyszkiewicz D, Koren G "The safety of Mlm-Dex in pregnancy - Results of a controlled study." Chest 119 (2001): 466-9
4. "Product Information. Benylin DM (Mlm-Dex)." Warner Lambert Laboratories, Morris Plains, NJ.
5. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References for breastfeeding information

1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
2. "Product Information. Benylin DM (Mlm-Dex)." Warner Lambert Laboratories, Morris Plains, NJ.

References

1. DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Vicks 44 Cough Relief: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

Consumer reviews

Information checked by Dr. Sachin Kumar, MD Pharmacology