Pregnancy of N-Acetil Cisteina in details
N-Acetil Cisteina crosses the placenta.
N-Acetil Cisteina may be used to treat acetaminophen overdose during pregnancy (Wilkes 2005). Delaying treatment to pregnant women with acetaminophen toxicity may increase the risk of adverse maternal and fetal outcomes. In general, medications used as antidotes should take into consideration the health and prognosis of the mother; antidotes should be administered to pregnant women if there is a clear indication for use and should not be withheld because of fears of teratogenicity (Bailey 2003).
N-Acetil Cisteina breastfeeding
Animal studies did not show adverse effects during lactation. It is unknown in this drug or its metabolites are excreted in milk. Based on the pharmacokinetics, it should be nearly cleared 30 hours after administration.
Use is not recommended. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: May consider resuming nursing 30 hours after the last administration.
See references
References for pregnancy information
- "Product Information. N-Acetil Cisteina." American Regent Laboratories Inc, Shirley, NY.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Briggs GG, Freeman RK, Yaffe SJ. "Drugs in Pregnancy and Lactation. 9th ed." Philadelphia, PA: Llippincott Williams & Wilkins (2011):
- "Product Information. Acetadote (N-Acetil Cisteina)." Cumberland-Swan Inc, Smyrna, TN.
References for breastfeeding information
- "Product Information. N-Acetil Cisteina." American Regent Laboratories Inc, Shirley, NY.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Acetadote (N-Acetil Cisteina)." Cumberland-Swan Inc, Smyrna, TN.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
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Information checked by Dr. Sachin Kumar, MD Pharmacology
