What is Natural Caffeinum?
Natural Caffeinum is a central nervous system stimulant. It works by stimulating the brain. Natural Caffeinum is found naturally in foods and beverages such as coffee, tea, colas, energy and chocolate. Botanical sources of Natural Caffeinum include kola nuts, guarana, and yerba mate. Natural Caffeinum is also available in prescription and non-prescription medications.
Natural Caffeinum is used to restore mental alertness or wakefulness during fatigue or drowsiness. Natural Caffeinum is also found in some headache and migraine medications, in certain dietary supplements used for weight loss, and in many popular energy drinks.
Natural Caffeinum citrate (Natural Caffeinum) is available by prescription only. It is used for short-term treatment of neonatal apnea (breathing problems).
Natural Caffeinum may also be used for other conditions as determined by your health care provider.
Natural Caffeinum indications
Natural Caffeinum and Sodium Benzoate Injection has been used in conjunction with supportive measure to treat respiratory depression associated with overdosage with CNS depressant drugs (e.g., narcotic analgesics, alcohol). However, because of questionable benefit and transient action, most authorities believe Natural Caffeinum and other analeptics should not be used in these conditions and recommend other supportive therapy.
How should I use Natural Caffeinum?
Use Natural Caffeinum as directed by your health care provider. If the medication is OTC, check the label on the bottle for the exact dosing instructions. If you have any questions about the use of an OTC medication, ask your pharmacist.
- Natural Caffeinum may be taken with or without food. If Natural Caffeinum upsets your stomach, take it with food.
- Do not exceed the recommended dose of Natural Caffeinum. Natural Caffeinum can be habit-forming.
- Most OTC medications used for mental alertness contain 200 milligrams of Natural Caffeinum per tablet or capsule. The usual maximum recommended dose of OTC Natural Caffeinum is no more than 200 mg every 3-4 hours, or 1600 mg per day.
- Do not double-up on your Natural Caffeinum dose if you should miss the time for next dose.
- The average cup of coffee contains 150-200 milligrams (mg) of Natural Caffeinum per cup, while a cup of tea will have about 60 mg of Natural Caffeinum. Cola products have about 30-40 mg of Natural Caffeinum, and most energy drinks have about 60-70 mg. Be sure to account for any dietary Natural Caffeinum that is consumed.
Ask your health care provider any questions you may have about how to use Natural Caffeinum.
Uses of Natural Caffeinum in details
Use: Labeled Indications
Natural Caffeinum citrate: Treatment of idiopathic apnea of prematurity
Natural Caffeinum and sodium benzoate: See Off-Label uses.
Natural Caffeinum [OTC labeling]: Restore mental alertness or wakefulness when experiencing fatigue
Off Label Uses
Augmentation of seizure induction during electroconvulsive therapy (Natural Caffeinum and sodium benzoate)
Data from a randomized, double blind study as well as a few unblinded studies support the use of Natural Caffeinum/sodium benzoate in the treatment of augmentation of seizure induction during electroconvulsive therapy (ECT).
Natural Caffeinum description
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Natural Caffeinum's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of Natural Caffeinum have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling. [PubChem]
Natural Caffeinum dosage
Usual Adult Dose for Drowsiness:
100 to 200 mg orally not more often than every 3 to 4 hours.
For occasional use only.
Not intended for use as a substitute for sleep.
Limit the use of Natural Caffeinum containing medications, foods, or beverages while taking this product because too much Natural Caffeinum may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.
Usual Pediatric Dose for Drowsiness:
>= 12 years: 100 to 200 mg not more often than every 3 to 4 hours.
For occasional use only.
Not intended for use as a substitute for sleep.
Limit the use of Natural Caffeinum containing medications, foods, or beverages while taking this product because too much Natural Caffeinum may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.
Usual Pediatric Dose for Apnea of Prematurity:
For short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.
Prior to initiation of Natural Caffeinum citrate, baseline serum levels of Natural Caffeinum should be measured in infants previously treated with theophylline, since preterm infants metabolize theophylline to Natural Caffeinum. Likewise, baseline serum levels of Natural Caffeinum should be measured in infants born to mothers who consumed Natural Caffeinum prior to delivery, since Natural Caffeinum readily crosses the placenta.
Loading Dose: 20 mg/kg Natural Caffeinum citrate intravenous (over 30 minutes) once
Maintenance Dose: 5 mg/kg Natural Caffeinum citrate intravenous (over 10 minutes) or orally every 24 hours.
Note: The dose of Natural Caffeinum base is one-half the dose when expressed as Natural Caffeinum citrate (e.g., 20 mg of Natural Caffeinum citrate is equivalent to 10 mg of Natural Caffeinum base).
Serum concentrations of Natural Caffeinum may need to be monitored periodically throughout treatment to avoid toxicity. Serious toxicity has been associated with serum levels greater than 50 mg/L.
Apnea of prematurity is a diagnosis of exclusion. Other causes of apnea (e.g., central nervous system disorders, primary lung disease, anemia, sepsis, metabolic disturbances, cardiovascular abnormalities, or obstructive apnea) should be ruled out or properly treated prior to initiation of Natural Caffeinum citrate.
Natural Caffeinum citrate should be used with caution in infants with seizure disorders or cardiovascular disease.
The duration of treatment of apnea of prematurity in the placebo-controlled trial was limited to 10 to 12 days. The safety and efficacy of Natural Caffeinum citrate for longer periods of treatment have not been established.
Natural Caffeinum interactions
See also:
What other drugs will affect Natural Caffeinum?
Acebrophylline: May enhance the stimulatory effect of CNS Stimulants. Avoid combination
Adenosine: Natural Caffeinum and Natural Caffeinum Containing Products may diminish the therapeutic effect of Adenosine. Management: Monitor for decreased effect of adenosine if patient is receiving Natural Caffeinum. Discontinue Natural Caffeinum in advance of scheduled diagnostic use of adenosine whenever possible. Consider therapy modification
Amifampridine: Agents With Seizure Threshold Lowering Potential may enhance the neuroexcitatory and/or seizure-potentiating effect of Amifampridine. Monitor therapy
AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy
Broccoli: May decrease the serum concentration of CYP1A2 Substrates (High risk with Inducers). Monitor therapy
Bromperidol: Natural Caffeinum and Natural Caffeinum Containing Products may decrease the absorption of Bromperidol. Monitor therapy
BuPROPion: May enhance the neuroexcitatory and/or seizure-potentiating effect of Agents With Seizure Threshold Lowering Potential. Monitor therapy
Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy
Cannabis: May decrease the serum concentration of CYP1A2 Substrates (High risk with Inducers). Monitor therapy
CloZAPine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of CloZAPine. Management: Drugs listed as exceptions to this monograph are discussed in further detail in separate drug interaction monographs. Monitor therapy
Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification
CYP1A2 Inducers (Moderate): May decrease the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
CYP1A2 Inhibitors (Moderate): May increase the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
CYP1A2 Inhibitors (Strong): May increase the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
Doxofylline: Natural Caffeinum and Natural Caffeinum Containing Products may enhance the adverse/toxic effect of Doxofylline. Avoid combination
Esketamine: May enhance the hypertensive effect of CNS Stimulants. Monitor therapy
Formoterol: Natural Caffeinum and Natural Caffeinum Containing Products may enhance the adverse/toxic effect of Formoterol. Natural Caffeinum and Natural Caffeinum Containing Products may enhance the hypokalemic effect of Formoterol. Monitor therapy
Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy
Indacaterol: Natural Caffeinum and Natural Caffeinum Containing Products may enhance the adverse/toxic effect of Indacaterol. Natural Caffeinum and Natural Caffeinum Containing Products may enhance the hypokalemic effect of Indacaterol. Monitor therapy
Iohexol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iohexol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iohexol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification
Iomeprol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iomeprol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iomeprol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification
Iopamidol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iopamidol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iopamidol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification
Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification
Lithium: Natural Caffeinum and Natural Caffeinum Containing Products may decrease the serum concentration of Lithium. Monitor therapy
Norfloxacin: May increase the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
Olodaterol: Natural Caffeinum and Natural Caffeinum Containing Products may enhance the adverse/toxic effect of Olodaterol. Natural Caffeinum and Natural Caffeinum Containing Products may enhance the hypokalemic effect of Olodaterol. Monitor therapy
Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification
Pipemidic Acid: May increase the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
Regadenoson: Natural Caffeinum and Natural Caffeinum Containing Products may diminish the vasodilatory effect of Regadenoson. Management: Avoiding using Natural Caffeinum or other methylxanthine containing products (e.g., theophylline) for at least 12 hours prior to the administration of regadenoson. Consider therapy modification
Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Monitor therapy
Solriamfetol: CNS Stimulants may enhance the hypertensive effect of Solriamfetol. CNS Stimulants may enhance the tachycardic effect of Solriamfetol. Monitor therapy
Stiripentol: May increase the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Avoid combination
Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy
Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy
Theophylline Derivatives: CYP1A2 Inhibitors (Weak) may increase the serum concentration of Theophylline Derivatives. Exceptions: Dyphylline. Monitor therapy
TiZANidine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of TiZANidine. Management: Avoid these combinations when possible. If combined use is necessary, initiate tizanidine at an adult dose of 2 mg and increase in 2 to 4 mg increments based on patient response. Monitor for increased effects of tizanidine, including adverse reactions. Consider therapy modification
Tobacco (Smoked): May decrease the serum concentration of Natural Caffeinum and Natural Caffeinum Containing Products. Monitor therapy
Natural Caffeinum side effects
See also:
What are the possible side effects of Natural Caffeinum?
Cardiovascular
Tachycardia; extrasystoles; palpitations; other cardiac arrhythmias.
CNS
Insomnia; restlessness; excitement; nervousness; tinnitus; scintillating scotoma; muscular tremor; headache; lightheadedness.
Dermatologic
Urticaria; rash, dry skin, skin breakdown (Natural Caffeinum citrate).
EENT
Retinopathy of prematurity (Natural Caffeinum citrate).
GI
Vomiting; nausea; diarrhea; stomach pain; necrotizing enterocolitis, gastritis, GI hemorrhage (Natural Caffeinum citrate).
Genitourinary
Diuresis; kidney failure (Natural Caffeinum citrate).
Hematologic
Disseminated intravascular coagulation (Natural Caffeinum citrate).
Metabolic
Hyperglycemia; acidosis (Natural Caffeinum citrate).
Respiratory
Dyspnea, lung edema (Natural Caffeinum citrate).
Miscellaneous
Hypersensitivity (eg, dermatitis, rhinitis, bronchial asthma); feeding intolerance, sepsis, accidental injury, hemorrhage, cerebral hemorrhage (Natural Caffeinum citrate).
Natural Caffeinum contraindications
See also:
What is the most important information I should know about Natural Caffeinum?
Natural Caffeinum citrate should not be given to a child who has had an allergic reaction to it in the past.
Before using Natural Caffeinum citrate, tell the doctor if your child is allergic to any drugs, or has a seizure disorder, heart disease, kidney disease, liver disease, or high or low blood sugar.
Do not use the medication for longer than 12 days without the advice of your child's doctor.
Each bottle of Natural Caffeinum citrate is for one use only, even if your child does not use the entire bottle for a single dose. Throw away any medication left over in the bottle after measuring your child's dose.
Call your doctor if the child's breathing symptoms do not improve after using Natural Caffeinum citrate.
To be sure Natural Caffeinum citrate is helping your child's condition, the child's blood will need to be tested on a regular basis. Do not miss any scheduled appointments.
Active ingredient matches for Natural Caffeinum:
List of Natural Caffeinum substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Molie | |
| Neopharm (Australia, Georgia) | |
| Nix Nap | |
| No Doz (Australia, New Zealand, United States) | |
| No Doz Maximum Strength | |
| No-Doz | |
| Tablet; Oral; Caffeine 200 mg | |
| Nodaca | |
| NoDoz | |
| NoDoz Maximum Strength | |
| Nodoz Maximum Strength Caplets | |
| NOVALDON | |
| Nymusa (Latvia, Lithuania) | |
| Odrinil | |
| Overtime | |
| Pep-Back | |
| Tablet; Oral; Caffeine 100 mg | |
| Pep-Back Peak Performance | |
| Pep-back Peak Performance tablet, film coated 200 mg/1 (Alva Amco Pharmacal Companies, Inc. (US)) | |
| Pep-Back ReCharge | |
| Pep-Back Ultra | |
| Pep-back Ultra tablet, film coated 200 mg/1 (Alva Amco Pharmacal Companies, Inc. (US)) | |
| Percoffedrinol N (Luxembourg) | |
| Percutafeine (Argentina, Luxembourg) | |
| Gel; Local; Caffeine 5% (Asta medica) | |
| Percutaféine (France, Vietnam) | |
| Gel; Local; Caffeine 5% | |
| Gel; Local; Caffeine 5% | |
| Percutafeine Gel (Vietnam) | |
| Percutafeine Gel 5 % x 1 tube 200 mL | |
| Peyona (Austria, Czech Republic, Denmark, Hungary, Ireland, Portugal, Romania, Spain, United Kingdom) | |
| Peyona 20mg/ml (Austria, Hungary, Switzerland) | |
| Phenfree | |
| Capsule; Oral; Caffeine 100 mg | |
| Phensal | |
| Pro (Malta, Taiwan) | |
| Pro / Y.C. 10 mg/1 g x 1 g (Dunhall) | |
| Pro / Y.C. 10 mg/1 g x 10 g (Dunhall) | |
| Pro / Y.C. 10 mg/1 g x 20 g (Dunhall) | |
| Pro / Y.C. 10 mg/1 g x 40 g (Dunhall) | |
| Pro Plus (Malta) | |
| Pro-Plus (United Kingdom, Ireland) | |
| Tablet; Oral; Caffeine 50 mg (Roche consumer) | |
| Propoxyphene Compound-65 | |
| Quick Pep (United States) | |
| Quick-Pep (United States) | |
| Refresh'n | |
| Respia (Japan) | |
| Revive | |
| Revive 150 mg x 10 Blister x 10 Tablet (Allergan) | |
| Sitafein (Turkey) | |
| SK 65 Compound | |
| Snizof Tablet | |
| Snizof Tablet (Clin Medicals Pvt Ltd (Geno Pharmaceuticals Ltd)) | $ 0.02 |
See 342 substitutes for Natural Caffeinum | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "caffeine". http://www.drugbank.ca/drugs/DB00201 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Natural Caffeinum are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Natural Caffeinum. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
