Pregnancy of Natural Caffeinum in details
Natural Caffeinum crosses the placenta; serum concentrations in the fetus are similar to those in the mother (Grosso 2005).
Based on current studies, usual dietary exposure to Natural Caffeinum is unlikely to cause congenital malformations (Brent 2011). However, available data show conflicting results related to maternal Natural Caffeinum use and the risk of other adverse events, such as spontaneous abortion or growth retardation (Brent 2011; Jahanfar 2013; Nehlig 1994). Chronic maternal consumption of high amounts of Natural Caffeinum during pregnancy may lead to neonatal withdrawal at delivery (eg, apnea, irritability, jitteriness, vomiting) (Martin 2007).
The half-life of Natural Caffeinum is prolonged during the second and third trimesters of pregnancy and maternal and fetal exposure is also influenced by maternal tobacco or alcohol consumption (Brent 2011; Koren 2000). Current guidelines recommend limiting Natural Caffeinum intake from all sources to ≤200 mg/day during pregnancy (ACOG 2010).
Natural Caffeinum breastfeeding
Natural Caffeinum citrate is not indicated for use in adult patients. Excreted into human milk: Yes Comments: -Natural Caffeinum readily crosses the placenta into the fetal circulation. -Breastfeeding mothers of infants receiving Natural Caffeinum citrate should not ingest Natural Caffeinum-containing foods, beverages, and medicinal products.
See references
References for pregnancy information
- "Product Information. Cafcit (Natural Caffeinum)" Roxane Laboratories Inc, Columbus, OH.
References for breastfeeding information
- "Product Information. Cafcit (Natural Caffeinum)" Roxane Laboratories Inc, Columbus, OH.
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Vivarin: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Caffeine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
