What is Neomycin 325?
Neomycin 325 is an antibiotic that fights bacteria in the body.
Neomycin 325 is used to reduce the risk of infection during surgery of your intestines. Neomycin 325 is also used to reduce the symptoms of hepatic coma.
Neomycin 325 may also be used for purposes not listed in this medication guide.
Neomycin 325 indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neomycin 325 Sulfate tablets and other antibacterial drugs, Neomycin 325 Sulfate tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Suppression of Intestinal Bacteria
Neomycin 325 Sulfate tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.
Hepatic Coma (Portal-Systemic Encephalopathy)
Neomycin 325 Sulfate has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.
How should I use Neomycin 325?
Use Neomycin 325 solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Neomycin 325 solution by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Neomycin 325 solution with plenty of water to avoid dehydration.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Take Neomycin 325 solution on a regular schedule to get the most benefit from it.
- To clear up your infection completely, use Neomycin 325 solution for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Neomycin 325 solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Neomycin 325 solution.
Uses of Neomycin 325 in details
Oral Neomycin 325 is used before the operation of the gut to kill the bacteria which normally live in the gut that may cause a serious infection and in treatment of patients with coma due to liver disease (hepatic coma).
Neomycin 325 description
A component of Neomycin 325 that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin 325 is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Neomycin 325 dosage
Neomycin 325 Dosage
Generic name: Neomycin 325 SULFATE 87.5mg in 5mL
Dosage form: oral solution
See also:
- Neomycin 325
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment for periods longer than two weeks is not recommended.
Hepatic coma
For use as an adjunct in the management of hepatic coma, the recommended dose is 4 to 12 grams per day given in the following regimen:
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Withdraw protein from diet. Avoid use of diuretic agents.
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Give supportive therapy including blood products, as indicated.
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Give Neomycin 325
Oral Solution in doses of four to twelve grams of Neomycin 325 sulfate per day in divided doses.
Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet.
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If less potentially toxic drugs cannot be used for chronic hepatic insufficiency, Neomycin 325 sulfate in doses of up to four grams daily may be necessary. The risks for the development of Neomycin 325 induced toxicity progressively increase when the treatment must be extended to preserve the life of a patient with hepatic encephalopathy who has failed to fully respond. Frequent periodic monitoring of these patients to ascertain the presence of drug toxicity is mandatory. Also, Neomycin 325 serum concentrations should be monitored to avoid potentially toxic levels. The benefits to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity and neuromuscular blockade following the accumulation of Neomycin 325 in the tissues.
More about Neomycin 325 (Neomycin 325)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
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Consumer resources
- Neomycin 325 solution
- Neomycin 325
- Neomycin 325 (Advanced Reading)
- Other brands: Neo-Tab
Professional resources
- Neomycin 325 (FDA)
- Neomycin 325 Sulfate (AHFS Monograph)
Related treatment guides
- Bowel Preparation
- Diarrhea
- Hepatic Coma
- Hepatic Encephalopathy
Neomycin 325 interactions
See also:
What other drugs will affect Neomycin 325?
Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Neomycin 325.
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Neomycin 325's nephrotoxicity and/or ototoxicity and potentiate Neomycin 325 sulfate's neuromuscular blocking effects.
Oral Neomycin 325 inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral Neomycin 325 sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.
Neomycin 325 side effects
See also:
What are the possible side effects of Neomycin 325?
Applies to Neomycin 325: oral solution, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Neomycin 325 (the active ingredient contained in Neomycin 325). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Neomycin 325:
Rare
- Any loss of hearing
- clumsiness
- diarrhea
- difficulty in breathing
- dizziness
- drowsiness
- greatly decreased frequency of urination or amount of urine
- increased amount of gas
- increased thirst
- light-colored, frothy, fatty-appearing stools
- ringing or buzzing or a feeling of fullness in the ears
- skin rash
- unsteadiness
- weakness
Minor Side Effects
Some of the side effects that can occur with Neomycin 325 may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Irritation or soreness of the mouth or rectal area
- nausea or vomiting
Neomycin 325 contraindications
See also:
What is the most important information I should know about Neomycin 325?
You should not take this medicine if you are allergic to Neomycin 325 or similar antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).
You should not take Neomycin 325 if you have ulcerative colitis, Crohn's disease, a blockage in your intestines, or other inflammatory bowel disease.
Do not use Neomycin 325 if you are pregnant. It could harm the unborn baby.
Before you take Neomycin 325, tell your doctor if you have kidney disease, myasthenia gravis, or Parkinson's disease.
Never take Neomycin 325 in larger amounts than recommended, or for longer than 2 weeks. High doses or long-term use of Neomycin 325 can cause serious kidney problems, or hearing loss that may not be reversible. The longer you take Neomycin 325, the more likely you are to develop these serious side effects.
To be sure this medication is not causing harmful effects, your kidney function, and your nerve and muscle function will need to be tested often. You may also need hearing tests. Neomycin 325 can have long lasting effects on your body. Do not miss any follow up visits to your doctor for blood or urine tests.
Neomycin 325 can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Neomycin 325, tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.
If you are being treated for hepatic coma, avoid eating foods that are high in protein. Follow your doctor's instructions about any other restrictions on food, beverages, or activity.
Active ingredient matches for Neomycin 325:
| Unit description / dosage (Manufacturer) | Price, USD |
| Powder; Oral; Neomycin Sulfate 81.25 g / 100 g | |
List of Neomycin 325 substitutes (brand and generic names): | |
| Neomycin Zoetis (United States) | |
| Neomycine 40 Agneau-Chevreau sevres Franvet (France) | |
| Neomycine 40 Lapin-Volaille-Porc Franvet (France) | |
| Neomycine 50 Coophavet (France) | |
| Néomycine 50% Virbac (France) | |
| Neomycine 50% Virbac (France) | |
| Néomycine Avitec (France) | |
| Néomycine Coophavet (France) | |
| Neomycine Diamant | |
| Solution; Ophthalmic; Neomycin Sulfate 3, 500 IU / ml | |
| Néomycine Franvet (France) | |
| Neomycine Unimed (Tunisia) | |
| Néomycine VIRBAC (France) | |
| Neomycinesulfaat (Netherlands) | |
| Neomycinesulfaat CF (Netherlands) | |
| Neomycinsulfat (Germany) | |
| Neomycinsulfat Chevita (Austria) | |
| Neomycinum (Poland) | |
| Neomycinum 0.5 % x 1 tube 3 g | |
| Neomycinum Jelfa (Poland) | |
| Neomycinum TC (Bulgaria) | |
| Neomycinum TZF (Poland) | |
| Neomycyna (Poland) | |
| Neomycyna Veto-Farma (Poland) | |
| Néomydiar (France) | |
| Neopolygramin | |
| Neopolygramin Eye 3 gm Ointment (Sunways India Pvt. Ltd.) | $ 0.03 |
| Neopt (Australia) | |
| Neosmin | |
| Neosmin 5 ml Drop (Calibre Pharmaceutical Pvt. Ltd.) | $ 0.03 |
| Neosol (Netherlands, Poland, United States) | |
| Solution; Oral; Methscopolamine Bromide 0.25 mg; Neomycin Sulfate 35 mg / ml (Breckenridge) | |
| NEOSOL 0.05% W/V OINTMENT 1 tube / 30 GM ointment each (Breckenridge) | $ 1.41 |
| Neosol 0.05% w/v Ointment (Breckenridge) | $ 0.05 |
| Neosol 100% voor kalvermelk (Netherlands) | |
| Neosporin Antibiotic | |
| Neosporin Antibiotic Skin 20 gm Ointment (Glaxo Smithkline Pharmaceuticals Ltd.) | $ 0.03 |
| Neosporin Eye DPS (India) | |
| Neosporin Eye DPS Polymyxin B sulphate 5000 u, Neomycin sulphate 3400 u, Gramicidin 0.025 mg/1 mL. EYE-SOLN / 5ml (GSK) | $ 0.29 |
| 5ml (GSK) | $ 0.29 |
| NEOSPORIN EYE DPS eye soln 5ml (GSK) | $ 0.29 |
| Neosporin-H DPS (India) | |
| Neosporin-H DPS Polymyxin B sulphate 10000 u, Neomycin sulphate 3400 u, Hydrocortisone 10 mg/1 mL. EAR-DPS / 5ml (GSK) | $ 0.48 |
| 5ml (GSK) | $ 0.48 |
| NEOSPORIN-H DPS ear drops 5ml (GSK) | $ 0.53 |
| Neosul (Pakistan) | |
| Neosulf (Australia) | |
| Suspension; Oral; Neomycin Sulfate 4.4 mg; Sulfamethazine 8.8 mg; Sulfathiazole 26.5 mg / ml (Alphapharm) | |
| Tablet; Oral; Neomycin Sulfate 500 mg (Alphapharm) | |
| Nepozin | |
| Nepozin 5 gm Ointment (Dupen Lab Pvt. Ltd.) | $ 0.23 |
See 287 substitutes for Neomycin 325 | |
References
- DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "neomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "neomycin". http://www.drugbank.ca/drugs/DB00452 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
