• Dosage of Neomycin Sulfate Sparhawk in details
• Neomycin Sulfate Sparhawk interactions
• Neomycin Sulfate Sparhawk reviews

Dosage of Neomycin Sulfate Sparhawk in details

Neomycin Sulfate Sparhawk Dosage

Generic name: Neomycin Sulfate Sparhawk SULFATE 87.5mg in 5mL

Dosage form: oral solution

See also:

• Neomycin Sulfate Sparhawk

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment for periods longer than two weeks is not recommended.

Hepatic coma

For use as an adjunct in the management of hepatic coma, the recommended dose is 4 to 12 grams per day given in the following regimen:

1. Withdraw protein from diet. Avoid use of diuretic agents.

2. Give supportive therapy including blood products, as indicated.

3. Give Neomycin Sulfate Sparhawk

   Oral Solution in doses of four to twelve grams of Neomycin Sulfate Sparhawk sulfate per day in divided doses.

   Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet.

4. If less potentially toxic drugs cannot be used for chronic hepatic insufficiency, Neomycin Sulfate Sparhawk sulfate in doses of up to four grams daily may be necessary. The risks for the development of Neomycin Sulfate Sparhawk induced toxicity progressively increase when the treatment must be extended to preserve the life of a patient with hepatic encephalopathy who has failed to fully respond. Frequent periodic monitoring of these patients to ascertain the presence of drug toxicity is mandatory. Also, Neomycin Sulfate Sparhawk serum concentrations should be monitored to avoid potentially toxic levels. The benefits to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity and neuromuscular blockade following the accumulation of Neomycin Sulfate Sparhawk in the tissues.

More about Neomycin Sulfate Sparhawk (Neomycin Sulfate Sparhawk)

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Consumer resources

• Neomycin Sulfate Sparhawk solution
• Neomycin Sulfate Sparhawk
• Neomycin Sulfate Sparhawk (Advanced Reading)

• Other brands: Neo-Tab

Professional resources

• Neomycin Sulfate Sparhawk (FDA)
• Neomycin Sulfate Sparhawk Sulfate (AHFS Monograph)

Related treatment guides

• Bowel Preparation
• Diarrhea
• Hepatic Coma
• Hepatic Encephalopathy

What other drugs will affect Neomycin Sulfate Sparhawk?

Neomycin Sulfate Sparhawk can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Neomycin Sulfate Sparhawk, tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.

Before you take Neomycin Sulfate Sparhawk, tell your doctor if you are using any other antibiotics, such as

• amikacin (Amikin)
• amphotericin-B (Amphotec);
• bacitracin (Baci IM);
• colistimethate (Coly Mycin M);
• gentamicin (Garamycin);
• kanamycin (Kantrex);
• paromomycin (Humatin, Paromycin);
• polymyxin B sulfate;
• penicillin V (PC Pen VK);
• streptomycin;
• tobramycin (Nebcin, Tobi); or
• vancomycin (Vancocin, Vancoled).

Tell your doctor about all other medicines you use, especially:

• cisplatin (Platinol);
• digoxin (digitalis, Lanoxin, Lanoxicaps);
• methotrexate (Rheumatrex, Trexall);
• vitamin B-12;
• antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or tenofovir (Viread);
• a blood thinner such as warfarin (Coumadin, Jantoven);
• a botulism toxin medication (Botox, Dysport, Myobloc, Xeomin, and others); or
• a diuretic (water pill) such as bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), or torsemide (Demadex).

This list is not complete and other drugs may interact with Neomycin Sulfate Sparhawk. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Neomycin Sulfate Sparhawk interactions

Acarbose: Neomycin Sulfate Sparhawk may enhance the adverse/toxic effect of Acarbose. Neomycin Sulfate Sparhawk may decrease the metabolism of Acarbose. Monitor therapy

Amphotericin B: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Arbekacin: May enhance the nephrotoxic effect of Aminoglycosides. Arbekacin may enhance the ototoxic effect of Aminoglycosides. Monitor therapy

Ataluren: May enhance the adverse/toxic effect of Aminoglycosides. Specifically, an increased risk of nephrotoxicity may occur with the concomitant use of ataluren and aminoglycosides. Avoid combination

Bacitracin (Systemic): Neomycin Sulfate Sparhawk may enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy

Bisphosphonate Derivatives: Aminoglycosides may enhance the hypocalcemic effect of Bisphosphonate Derivatives. Monitor therapy

Botulinum Toxin-Containing Products: Aminoglycosides may enhance the neuromuscular-blocking effect of Botulinum Toxin-Containing Products. Monitor therapy

Capreomycin: May enhance the neuromuscular-blocking effect of Aminoglycosides. Monitor therapy

CARBOplatin: Aminoglycosides may enhance the ototoxic effect of CARBOplatin. Especially with higher doses of carboplatin. Monitor therapy

Cardiac Glycosides: Aminoglycosides may decrease the serum concentration of Cardiac Glycosides. This effect has only been demonstrated with oral aminoglycoside administration. Monitor therapy

Cefazedone: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Cephalosporins (2nd Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Cephalosporins (3rd Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Cephalosporins (4th Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Cephalothin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Cephradine: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

CISplatin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Colistimethate: Aminoglycosides may enhance the nephrotoxic effect of Colistimethate. Aminoglycosides may enhance the neuromuscular-blocking effect of Colistimethate. Management: Avoid coadministration of colistimethate and aminoglycosides whenever possible due to the risk of nephrotoxicity and neuromuscular blockade. If coadministration cannot be avoided, monitor renal and neuromuscular function. Consider therapy modification

CycloSPORINE (Systemic): Aminoglycosides may enhance the nephrotoxic effect of CycloSPORINE (Systemic). Monitor therapy

Distigmine: Aminoglycosides may diminish the therapeutic effect of Distigmine. Monitor therapy

Foscarnet: May enhance the nephrotoxic effect of Aminoglycosides. Avoid combination

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy

Loop Diuretics: May enhance the adverse/toxic effect of Aminoglycosides. Specifically, nephrotoxicity and ototoxicity. Monitor therapy

Mannitol (Systemic): May enhance the nephrotoxic effect of Aminoglycosides. Avoid combination

Mecamylamine: Aminoglycosides may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination

Methoxyflurane: Aminoglycosides may enhance the nephrotoxic effect of Methoxyflurane. Avoid combination

Neuromuscular-Blocking Agents: Aminoglycosides may enhance the therapeutic effect of Neuromuscular-Blocking Agents. Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May decrease the excretion of Aminoglycosides. Data only in premature infants. Monitor therapy

Oxatomide: May enhance the ototoxic effect of Aminoglycosides. Monitor therapy

Penicillins: May decrease the serum concentration of Aminoglycosides. Primarily associated with extended spectrum penicillins, and patients with renal dysfunction. Exceptions: Amoxicillin; Ampicillin; Bacampicillin; Cloxacillin; Dicloxacillin; Nafcillin; Oxacillin; Penicillin G (Parenteral/Aqueous); Penicillin G Benzathine; Penicillin G Procaine; Penicillin V Benzathine; Penicillin V Potassium. Consider therapy modification

Regorafenib: Neomycin Sulfate Sparhawk may decrease serum concentrations of the active metabolite(s) of Regorafenib. Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification

SORAfenib: Neomycin Sulfate Sparhawk may decrease the serum concentration of SORAfenib. Monitor therapy

Tenofovir Products: Aminoglycosides may increase the serum concentration of Tenofovir Products. Tenofovir Products may increase the serum concentration of Aminoglycosides. Monitor therapy

Vancomycin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy

Vitamin K Antagonists (eg, warfarin): Neomycin Sulfate Sparhawk may enhance the anticoagulant effect of Vitamin K Antagonists. Monitor therapy

References

1. DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "4BOC774388: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology