What is Netazox DT?
Netazox DT belongs to a group of medicines called antiprotozoals. It is used to treat diarrhea that is caused by certain types of protozoa (tiny, one-celled animals).
Netazox DT is available only with your healthcare professional's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Netazox DT is used in certain patients with the following medical condition:
- Intestinal parasitic infections
Netazox DT indications
Diarrhea Caused by Giardia Lamblia or Cryptosporidium Parvum
Netazox DT for
Oral Suspension (patients 1 year of age and older) and Netazox DT Tablets (patients 12 years and older) are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.
Limitations Of Use
Netazox DT for
Oral Suspension and Netazox DT Tablets have not been shown to be effective for the treatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.
How should I use Netazox DT?
Use Netazox DT suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Netazox DT suspension with food.
- Shake well before using.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- If you miss a dose of Netazox DT suspension, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Netazox DT suspension.
Uses of Netazox DT in details
Use: Labeled Indications
Diarrhea, infectious: Treatment of diarrhea caused by Cryptosporidium parvum or Giardia lamblia
Off Label Uses
Clostridioides (formerly Clostridium) difficile infection
Current evidence from small, controlled trials regarding the use of Netazox DT in the management of C. difficile infection suggests that it may be comparable to the use of oral metronidazole or vancomycin. The Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology (SHEA) clinical practice guidelines for C. difficile infection state that Netazox DT is considered a probable effective alternative for primary C. difficile infection in adults without specific recommendations for use. Larger controlled trials are needed.
Cryptosporidiosis-associated diarrhea in HIV-infected patients
Based on the US Department of Health and Human Services (HHS) Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Netazox DT may be considered as an alternative agent in the management of diarrhea caused by Cryptosporidium in HIV-infected patients (must be used in combination with optimized antiretroviral therapy (ART), electrolyte replacement, and symptomatic treatment and rehydration).
Netazox DT description
Netazox DT, also known by the brand name Netazox DT, is a synthetic nitrothiazolyl-salicylamide derivative and an anti-protozoal agent. It is approved for treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. Following oral administration it is rapidly hydrolyzed to its active metabolite, tizoxanide, which is 99% protein bound. Peak concentrations are observed 1–4 hours after administration. It is excreted in the urine, bile and feces. Untoward effects include abdominal pain, vomiting and diarrhea. [Wikipedia]
Netazox DT dosage
Netazox DT Dosage
Generic name: Netazox DT 500mg
Dosage form: tablet; powder, for oral suspension
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
2.1 Recommended Dosage and Important Administration Instructions
Important Administration Instructions for Pediatric Patients 11 years of Age or Younger:
Netazox DT tablets should not be administered to pediatric patients 11 years of age or younger because a single tablet contains a greater amount of Netazox DT than the recommended dosing in this pediatric age group.
Table 1. Recommended Dosage
| Age | Dosage | Duration |
| 1-3 years | 5 mL of Netazox DT for Oral suspension(100 mg Netazox DT) taken orally every 12 hours with food | |
| 4-11 years | 10 mL of Netazox DT for Oral Suspension(200 mg Netazox DT) taken orally every 12 hours with food | 3 Days |
| 12 years and older | One Netazox DT Tablet (500 mg Netazox DT) taken orally every 12 hours with food or 25 mL of Netazox DT for Oral Suspension (500 mg Netazox DT) taken orally every 12 hours with food |
2.2 Directions for Mixing Netazox DT for
Oral Suspension
Reconstitute Netazox DT for
Oral Suspension as follows:
- Measure 48 mL of water for preparation of the 100 mg/5 mL suspension
- Tap bottle until all powder flows freely.
- Add approximately one-half of the 48 mL of water required for reconstitution and shake vigorously to suspend powder.
- Add remainder of water and again shake vigorously
Keep container tightly closed, and shake the suspension well before each administration. The reconstituted suspension may be stored for 7 days at room temperature, after which any unused portion must be discarded.
More about Netazox DT (Netazox DT)
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Consumer resources
- Netazox DT
- Netazox DT suspension
- Netazox DT (Advanced Reading)
Professional resources
- Netazox DT (AHFS Monograph)
- Netazox DT (FDA)
Related treatment guides
- Ascariasis
- Giardiasis
- Dwarf Tapeworm Infection (Hymenolepis nana)
- Amebiasis
- Cryptosporidiosis
Netazox DT interactions
See also:
What other drugs will affect Netazox DT?
Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering Netazox DT concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin). In vitro metabolism studies have demonstrated that tizoxanide has no significant inhibitory effect on cytochrome P450 enzymes. Although no drug-drug interaction studies have been conducted in vivo, it is expected that no significant interaction would occur when Netazox DT is co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes.
Netazox DT side effects
See also:
What are the possible side effects of Netazox DT?
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The safety of Netazox DT was evaluated in 2177 HIV-uninfected subjects 12 months of age and older who received Netazox DT Tablets or Netazox DT for
Oral Suspension at the recommended dose for at least three days. In pooled controlled clinical trials involving 536 HIV-uninfected subjects treated with Netazox DT Tablets or Netazox DT for
Oral Suspension, the most common adverse reactions were abdominal pain, headache, chromaturia and nausea ( > 2%).
Safety data were analyzed separately for 280 HIV-uninfected subjects ≥ 12 years of age receiving Netazox DT at the recommended dose for at least three days in 5 placebo-controlled clinical trials and for 256 HIV-uninfected subjects 1 through 11 years of age in 7 controlled clinical trials. There were no differences between the adverse reactions reported for Netazox DT-treated subjects based upon age.
Postmarketing Experience
The following adverse reactions have been identified during post approval use of Netazox DT. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following is a list of adverse reactions spontaneously reported with Netazox DT Tablets which were not included in clinical trial listings:
Gastrointestinal disorders: diarrhea, gastroesophageal reflux disease
Nervous System disorders: dizziness
Respiratory, thoracic and mediastinal disorders: dyspnea
Skin and subcutaneous tissue disorders: rash, urticaria
Netazox DT contraindications
See also:
What is the most important information I should know about Netazox DT?
Hypersensitivity
Netazox DT Tablets and Netazox DT for
Oral Suspension are contraindicated in patients with a prior hypersensitivity to Netazox DT or any other ingredient in the formulations.
Active ingredient matches for Netazox DT:
| Unit description / dosage (Manufacturer) | Price, USD |
| Netazox DT 200 mg Tablet | $ 0.06 |
List of Netazox DT substitutes (brand and generic names): | |
| Netazox FC | |
| Netazox FC 500 mg Tablet (Ind-Swift Limited) | $ 0.09 |
| Niazid (Bangladesh) | |
| Nicud (Bangladesh) | |
| Nidozox (Bangladesh) | |
| Nit Clean (Egypt) | |
| Nitacol | |
| Nitacol 30 ml Suspension (Rexcel Pharmaceuticals Ltd) | $ 0.04 |
| Nitacure (India) | |
| Nitacure 200mg FC-TAB / 6 (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.31 |
| Nitacure 500mg FC-TAB / 6 (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.59 |
| 200 mg x 6's (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.31 |
| 500 mg x 6's (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.59 |
| Nitacure 30 ml Syrup (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.05 |
| Nitacure 200 mg Tablet (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.05 |
| Nitacure 500 mg Tablet (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.09 |
| NITACURE film-coated tab 200 mg x 6's (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.31 |
| NITACURE film-coated tab 500 mg x 6's (Megacare (Alembic Chemical Works Co Ltd)) | $ 0.65 |
| NITACURE SYP (India) | |
| 100 mg x 30ml (Alembic) | $ 0.29 |
| Nitacure SYP 100mg DRY-SYR / 30ml (Alembic) | $ 0.29 |
| NITACURE SYP dry syr 100 mg x 5 mL x 30ml (Alembic) | $ 0.29 |
| Nitacure SYP 100mg DRY-SYR / 30ml (Alembic) | $ 0.29 |
| NITADOX (India) | |
| NITADOX tab 500 mg x 6's (Signova) | $ 0.54 |
| Nitahelmin (Colombia) | |
| Nitanid (Bangladesh, Ecuador) | |
| NITARID (India) | |
| NITARID Capsule/ Tablet / 500mg / 6 units (Cipla Limited) | $ 0.54 |
| NITARID Dispersible Tablet / 200mg / 6 units (Cipla Limited) | $ 0.39 |
| NITARID Liquid / 10gm per 30ml / 30ml units (Cipla Limited) | $ 0.24 |
| 200 mg x 6's (Cipla Limited) | $ 0.39 |
| 500 mg x 6's (Cipla Limited) | $ 0.54 |
| 30ml (Cipla Limited) | $ 0.24 |
| Nitarid 200mg DT-TAB / 6 (Cipla Limited) | $ 0.39 |
| Nitarid 500mg TAB / 6 (Cipla Limited) | $ 0.54 |
| Nitarid - DRY-SYR / 30ml (Cipla Limited) | $ 0.24 |
| Nitarid 500 mg Tablet (Cipla Limited) | $ 0.10 |
| Nitarid 30 ml Syrup (Cipla Limited) | $ 0.24 |
| NITARID 100 MG SYRUP 1 bottle / 30 ML syrup each (Cipla Limited) | $ 0.25 |
| NITARID 200 MG TABLET DT 1 strip / 6 tablet dts each (Cipla Limited) | $ 0.32 |
| NITARID dispertab 200 mg x 6's (Cipla Limited) | $ 0.39 |
| NITARID tab 500 mg x 6's (Cipla Limited) | $ 0.54 |
| NITARID dry syr 100 mg x 5 mL x 30ml (Cipla Limited) | $ 0.24 |
| Nitarid 200mg DT-TAB / 6 (Cipla Limited) | $ 0.39 |
| Nitarid 500mg TAB / 6 (Cipla Limited) | $ 0.54 |
| Nitarid - DRY-SYR / 30ml (Cipla Limited) | $ 0.24 |
| Nitarid 100mg Syrup (Cipla Limited) | $ 0.25 |
See 375 substitutes for Netazox DT | |
References
- DailyMed. "NITAZOXANIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "NITAZOXANIDE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "NITAZOXANIDE". http://www.drugbank.ca/drugs/DB00507 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Netazox DT are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Netazox DT. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yet1 consumer reported time for results
To what extent do I have to use Netazox DT before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Netazox DT. To get the time effectiveness of using Netazox DT drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
2 consumers reported age
| Users | % | ||
|---|---|---|---|
| 1-5 | 1 | 50.0% | |
| 6-15 | 1 | 50.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
