What is Nexlosar?
Nexlosar is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of strokes and heart attacks.
Nexlosar is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, Nexlosar relaxes the blood vessels. A lower blood pressure will increase the supply of the blood and oxygen to the heart.
Nexlosar is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart. It is also used to treat kidney problems in patients with type 2 diabetes and a history of hypertension.
Nexlosar is available only with your doctor's prescription.
Nexlosar indications
Nexlosar is used to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Nexlosar works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, Nexlosar relaxes blood vessels. This lowers blood pressure.
Nexlosar is also used to decrease the risk of stroke in patients with high blood pressure and a condition called left ventricular hypertrophy (LVH). LVH is an enlargement of the left pumping chamber of the heart and can cause problems with the way the heart pumps blood.
Nexlosar is also used to treat a condition called diabetic nephropathy. Diabetic nephropathy is a complication of type 2 diabetes which causes the kidneys to not work properly.
How should I use Nexlosar?
Use Nexlosar as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Nexlosar. Talk to your pharmacist if you have questions about this information.
- Take Nexlosar by mouth with or without food.
- If you cannot swallow tablets, ask your doctor or pharmacist about preparing a suspension of Nexlosar.
- Take Nexlosar on a regular schedule to get the most benefit from it. Taking Nexlosar at the same time each day will help you remember to take it.
- Continue to take Nexlosar even if you feel well. Do not miss any doses.
- If you miss a dose of Nexlosar, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Nexlosar.
Uses of Nexlosar in details
Use: Labeled Indications
Hypertension: Management of hypertension in adults and children ≥6 years of age
Proteinuric chronic kidney disease, diabetic: Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio ≥300 mg/g) in patients with type 2 diabetes and a history of hypertension
Off Label Uses
Heart failure with reduced ejection fraction
Data from a randomized, double-blind, dose comparison study in patients with New York Heart Association (NYHA) class II to IV heart failure support the use of Nexlosar at higher doses to reduce the rate of death or admission for heart failure in patients with heart failure.
Proteinuric chronic kidney disease, nondiabetic
Based on the 2012 Kidney Disease Improving Global Outcomes guidelines, the use of an ACE inhibitor or an ARB is recommended in patients with proteinuric CKD to prevent progression of CKD.
ST-elevation myocardial infarction
Based on the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infraction, an ARB is recommended and effective in patients who have indications for but are intolerant of ACE inhibitors.
Nexlosar description
Nexlosar, the first of a new class of agents for the treatment of hypertension, is an angiotensin II receptor (type AT1) antagonist. Nexlosar also provides a reduction in the combined risk of cardiovascular death, stroke, and myocardial infarction in hypertensive patients with left ventricular hypertrophy and renal protection for type 2 diabetic patients with proteinuria.
Nexlosar, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt.
Its empirical formula is C22H22ClKN6O.
Nexlosar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone.
Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of Nexlosar.
Nexlosar dosage
Hypertension: The usual starting and maintenance dose is 50 mg once daily for most patients. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose to 100 mg once daily.
For patients with intravascular volume-depletion (e.g., those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered.
No initial dosage adjustment is necessary for elderly patients or for patients with renal impairment, including patients on dialysis. A lower dose should be considered for patients with a history of hepatic impairment.
Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is 50 mg of Nexlosar once daily. A low dose of hydrochlorothiazide should be added and/or the dose of Nexlosar should be increased to 100 mg once daily based on blood pressure response.
Renal Protection in Type 2 Diabetic Patients with Proteinuria: The usual starting dose is 50 mg once daily. The dose may be increased to 100 mg once daily based on blood pressure response. Nexlosar may be administered with other antihypertensive agents (e.g., diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) as well as with insulin and other commonly used hypoglycemic agents (e.g., sulfonylureas, glitazones and glucosidase inhibitors).
Administration: Nexlosar may be administered with or without food.
Nexlosar may be administered with other antihypertensive agents.
Nexlosar interactions
See also:
What other drugs will affect Nexlosar?
Using Nexlosar with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Lithium
Using Nexlosar with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Aceclofenac
Acemetacin
Alclofenac
Apazone
Benoxaprofen
Bromfenac
Bufexamac
Carprofen
Celecoxib
Clometacin
Clonixin
Dexketoprofen
Diclofenac
Diflunisal
Dipyrone
Droxicam
Etodolac
Etofenamate
Felbinac
Fenbufen
Fenoprofen
Fentiazac
Floctafenine
Fluconazole
Flufenamic Acid
Flurbiprofen
Ibuprofen
Indomethacin
Indoprofen
Isoxicam
Ketoprofen
Ketorolac
Lornoxicam
Meclofenamate
Mefenamic Acid
Meloxicam
Nabumetone
Naproxen
Niflumic Acid
Nimesulide
Oxaprozin
Oxyphenbutazone
Phenylbutazone
Pirazolac
Piroxicam
Pirprofen
Propyphenazone
Proquazone
Rifampin
Rofecoxib
Sulindac
Suprofen
Tenidap
Tenoxicam
Tiaprofenic Acid
Tolmetin
Valdecoxib
Zomepirac
Nexlosar side effects
See also:
What are the possible side effects of Nexlosar?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Hoarseness
swelling of face, mouth, hands, or feet
trouble in swallowing or breathing (sudden)
Incidence not known
Abdominal pain
black, tarry stools
bleeding gums
blood in urine or stools
coma
confusion
convulsions
decreased urine output
difficult breathing
fast or irregular breathing
headache
increased thirst
irregular heartbeat
large, flat, bluish patches on the skin
muscle pain or cramps
nausea or vomiting
painful knees and ankles
pinpoint red spots on skin
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal pain
weakness or heaviness of legs
yellow eyes and skin
Check with your doctor as soon as possible if any of the following side effects occur:
Less common
Cough, fever or sore throat
dizziness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Headache
Less common
Back pain
diarrhea
fatigue
nasal congestion
Rare
Cough, dry
leg pain
muscle cramps or pain
sinus problems
trouble in sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Nexlosar contraindications
See also:
What is the most important information I should know about Nexlosar?
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Nexlosar, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to Nexlosar or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Active ingredient matches for Nexlosar:
| Unit description / dosage (Manufacturer) | Price, USD |
| Nexlosar 25 mg Tablet | $ 0.04 |
| Nexlosar 50 mg Tablet | $ 0.06 |
List of Nexlosar substitutes (brand and generic names): | |
| LSR (India) | |
| LSR tab 50 mg x 10's (Medihealth) | $ 0.52 |
| Nexlosar H | |
| Nexlosar H 50+12.5 Tablet (Nexus Biotech) | $ 0.06 |
| Nexlosar H 25+12.5 Tablet (Nexus Biotech) | $ 0.05 |
| Omnitan H | |
| Omnitan H 50+12.5 Tablet (Macleods Pharmaceuticals Pvt Ltd.) | $ 0.07 |
| OMNITAN H 50 MG/12.5 MG TABLET 1 strip / 15 tablets each (Macleods Pharmaceuticals Pvt Ltd.) | $ 1.44 |
| Omnitan H 50 mg/12.5 mg Tablet (Macleods Pharmaceuticals Pvt Ltd.) | $ 0.11 |
| Osar | |
| Osar 50 mg Tablet (Ortin Laboratories Ltd) | $ 0.06 |
| Osart H | |
| Osart H 50+12.5 Tablet (Invision Medi Sciences) | $ 0.06 |
| OSART H 50MG/12.5MG TABLET 1 strip / 10 tablets each (Invision Medi Sciences) | $ 0.63 |
| Osart H 50 mg/12.5 mg Tablet (Invision Medi Sciences) | $ 0.06 |
| Oslo K | |
| Oslo K 25 mg Tablet (G.M.H. Laboratories) | $ 0.03 |
| Pyzacar 25/50 (Vietnam) | |
| Pyzacar 25/50 25 mg x 2 Blister x 15 Tablet | |
| Pyzacar 25/50 50 mg x 2 Blister x 15 Tablet | |
| Resillo | |
| Resillo Capsule/ Tablet / 50mg / 10 units (Dr. Reddy's Laboratories) | $ 0.54 |
| Resillo Capsule/ Tablet / 25mg / 10 units (Dr. Reddy's Laboratories) | $ 0.23 |
| Saan | |
| Saan 50 mg Tablet (Hinglaj Laboratories of India) | $ 0.04 |
| Smilor | |
| Smilor 50+5 Tablet (Smithcare Remedies) | $ 0.07 |
| Tank H | |
| Tank H 50+12.5 Tablet (Fillips Pharma) | $ 0.05 |
| TANZAR (India) | |
| 50 mg x 10's (Tan) | $ 0.53 |
| Tanzar 50mg TAB / 10 (Tan) | $ 0.53 |
| TANZAR tab 50 mg x 10's (Tan) | $ 0.53 |
| Tanzar 50mg TAB / 10 (Tan) | $ 0.53 |
| Tosar | |
| Tosar 50 mg Tablet (Welbe Life Sciences) | $ 0.05 |
| Tozaar H | |
| Tozaar H 50+12.5 Tablet (Torrent Labs (P) Ltd.) | $ 0.09 |
| TOZAAR H 50 MG/12.5 MG TABLET 1 strip / 10 tablets each (Torrent Labs (P) Ltd.) | $ 1.05 |
| Tozaar R | |
| Tozaar R 50+2.5 Tablet (Torrent Labs (P) Ltd.) | $ 0.09 |
| Tozaar R 50+5 Tablet (Torrent Labs (P) Ltd.) | $ 0.12 |
| Tozaar R Tablet (Torrent Labs (P) Ltd.) | $ 0.09 |
| Unisart H | |
| Unisart H 50+12.5 Tablet (Unicorn (India)) | $ 0.06 |
| Vida FC | |
| Vida FC 25 mg Tablet (Lupin Laboratories Ltd.) | $ 0.03 |
| Vida FC 50 mg Tablet (Lupin Laboratories Ltd.) | $ 0.06 |
| Vida H | |
| Vida H 50+12.5 Tablet (Lupin Laboratories Ltd.) | $ 0.06 |
| Vilos H | |
| Vilos H 50+12.5 Tablet (Anvi Pharmaceuticals) | $ 0.07 |
| Zaart - 25 | |
| Zaart - 25 Capsule/ Tablet / 25mg / 10 units (Cipla) | $ 0.31 |
| Zaart - 50 | |
| Zaart - 50 Capsule/ Tablet / 50mg / 10 units (Cipla) | $ 0.59 |
| Zaart H | |
| Zaart H 50+12.5 Tablet (Cipla Limited) | $ 0.07 |
| ZAART H 50 MG/12.5 MG TABLET 1 strip / 10 tablets each (Cipla Limited) | $ 1.04 |
| Zargo H | |
| Zargo H 50+12.5 Tablet (Biocon Limited) | $ 0.05 |
| ZARGO H 50 MG/12.5 MG TABLET 1 strip / 10 tablets each (Biocon Limited) | $ 0.90 |
| Zargo H 50 mg/12.5 mg Tablet (Biocon Limited) | $ 0.09 |
| Zarlo | |
| Zarlo 50 mg Tablet (Grandix Pharmaceuticals) | $ 0.04 |
| Zarlo 25 mg Tablet (Grandix Pharmaceuticals) | $ 0.02 |
See 229 substitutes for Nexlosar | |
References
- DailyMed. "LOSARTAN POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "losartan". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "losartan". http://www.drugbank.ca/drugs/DB00678 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Nexlosar are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Nexlosar. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
