Noliprel Forte Arginine Dosage

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Dosage of Noliprel Forte Arginine in details

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Noliprel Forte Arginine 5 mg/1.25 mg Tablet: If blood pressure is not controlled after 1 month of treatment, the dose should be titrated to one 5 mg/1.25 mg tablet/day as a single dose, preferably to be taken in the morning and before a meal. When clinically appropriate, direct change from monotherapy to 5 mg/1.25 mg film-coated tablet may be considered.

Noliprel Forte Arginine 10 mg/2.5 mg Tablet: One 10 mg/2.5 mg as a single dose, preferably to be taken in the morning and before a meal.

Elderly: In elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated with Noliprel Forte Arginine 5 mg/1.25 mg and 10 mg/2.5 mg if renal function is normal and after considering blood pressure response.

Renal Impairment: In severe renal impairment (creatinine clearance <30 mL/min), treatment is contraindicated.

In moderate renal impairment (creatinine clearance <60 mL/min), treatment is contraindicated to Noliprel Forte Arginine 10 mg/2.5 mg.

Noliprel Forte Arginine 5 mg/1.25 mg Tablet: In patients with moderate renal impairment (creatinine clearance 30-60 mL/min), it is recommended to start treatment with the adequate dosage of the free combination.

In patients with creatinine clearance ≥60 mL/min, no dose modification is required.

Usual medical follow-up will include frequent monitoring of creatinine and potassium.

Hepatic Impairment: In severe hepatic impairment, treatment is contraindicated.

In patients with moderate hepatic impairment, no dose modification is required.

Noliprel Forte Arginine interactions

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Avoid Noliprel Forte Arginine with lithium, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium salts.

Caution in use of Noliprel Forte Arginine with the following drugs: Other medicines for treating high blood pressure; procainamide; allopurinol; terfenadine or astemizole; corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis; immunosuppressants used for the treatment of autoimmune disorders or following transplant surgery to prevent rejection (eg, cyclosporin); medicines for the treatment of cancer; erythromycin by injection; halofantrine; pentamidine; injectable gold; vincamine; bepridil; sulfopride; medicines used for heart rhythm problems (eg, quinidine, hydroquinidine, disopyramide, amiodarone, sotalol); digoxin or other cardiac glycosides; baclofen; medicines used to treat diabetes eg, insulin or metformin; calcium, including calcium supplements; stimulant laxatives (eg, senna); nonsteroidal anti-inflammatory drugs (eg, ibuprofen) or high-dose salicylates (eg, aspirin); amphotericin B by injection; medicines to treat mental disorders eg, depression, anxiety, schizophrenia (eg, tricyclic antidepressants, neuroleptics); tetracosactide.


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References

  1. DailyMed. "INDAPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "Y5GMK36KGY: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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