Norethisterone acetate indications
contraceptive
Uses of Norethisterone acetate in details
Norethisterone acetate is a man-made form of progesterone, a naturally occurring female sex hormone. It has a number of uses:
- Low-strength progesterone is used in oral contraceptive pill to prevent pregnancy.
- Medium-strength progesterone is used, to treat irregular, painful or heavy periods, to treat endometriosis (where tissue from the lining of the womb is present in places where it is not normally found), to treat premenstrual syndrome (also known as premenstrual tension, PMS or PMT), to delay periods.
Norethisterone acetate description
Norethisterone acetate (INN, BAN), also known as Norethindrone (USAN), is a synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Norethisterone acetate dosage
Norethisterone acetate Tablets
Therapy with Norethisterone acetate tablets must be adapted to the specific indications and therapeutic response of the individual patient.
Secondary Amenorrhea, Abnormal Uterine Bleeding due to Hormonal Imbalance in the Absence of Organic Pathology
2.5 to 10 mg Norethisterone acetate tablets may be given daily for 5 to 10 days to produce secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen.
Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing Norethisterone acetate tablets therapy. Patients with a past history of recurrent episodes of abnormal uterine bleeding may benefit from planned menstrual cycling with Norethisterone acetate tablets.
Endometriosis
Initial daily dosage of 5 mg Norethisterone acetate tablets for two weeks. Dosage should be increased by 2.5 mg per day every two weeks until 15 mg per day of Norethisterone acetate tablets is reached. Therapy may be held at this level for six to nine months or until annoying breakthrough bleeding demands temporary termination.
Norethisterone acetate interactions
Barbiturates, phenyl butazone, hydantoins, rifampicin and ampicillin may impair the action of steroid hormones like Norethisterone acetate.
Insulin and antidiabetic requirements may be changed.
Norethisterone acetate side effects
Rarely some nausea may occur.
Norethisterone acetate contraindications
Pregnancy.
Severe disturbance of liver function.
Thromboembolic process.
History of jaundice or pruritus during pregnancy.
Active ingredient matches for Norethisterone acetate:
Norethisterone acetate
List of Norethisterone acetate substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| COROLUT-N (India) | |
| 5 mg x 10's (Triton (Corolla)) | |
| COROLUT-N tab 5 mg x 10's (Triton (Corolla)) | $ 0.60 |
| Norcolut 5 | |
| Norestin 5 | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
