Consists of Crataegus, Guaifenesin, Lupulus, Melissa, Passion Flower, Sambucus, St. John's Wort, Valerian
Pregnancy of Guaifenesin (Novo-Passit) in details
The Collaborative Perinatal Project reported 197 first-trimester exposures to Guaifenesin (Novo-Passit). Fourteen malformations were reported for a relative risk not significantly different from 1.0. In a review of 229,101 deliveries to Michigan Medicaid patients, 141 first-trimester exposures to Guaifenesin (Novo-Passit) and 349 exposures anytime during pregnancy were recorded. A total of 9 birth defects were reported with first trimester exposure (6 expected) and included 2 cardiovascular defects. These data do not support an association between Guaifenesin (Novo-Passit) and birth defects. (written communication, Franz Rosa, MD, Food and Drug Administration, 1994)
Guaifenesin (Novo-Passit) has been assigned to pregnancy category C. by the FDA. There are no controlled data in human pregnancy. Guaifenesin (Novo-Passit) is only recommend for use during pregnancy when benefit outweighs risk.
See references
Guaifenesin (Novo-Passit) breastfeeding
There are no data on the excretion of Guaifenesin (Novo-Passit) into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- "Product Information. Humabid (Guaifenesin (Novo-Passit))." Medeva Pharmaceuticals, Rochester, NY.
- Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
References for breastfeeding information
- Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
References
- DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Mucinex: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Guaifenesin: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
