Novo-Pen G indications
Prophylactic: Recurrence of rheumatic fever. Treatment of mild to moderate infections caused by sensitive organisms: Pneumococcal infections of the middle ear; Streptococcal otitis media and sinusitis; Streptococcal pharyngitis caused by Strep pyogenes; mild to moderate pulmonary and periodontal anaerobic infections; gingivostomatitis; early Lyme disease.
Uses of Novo-Pen G in details
Novo-Pen G (also known as benzyl penicillin) is used:
- To treat bacterial infections of the wound, blood (septicemia and pyemia), bone (osteomyelitis), pus filled (pyogenic) skin or soft tissue, nose, throat, respiratory tract, and middle ear.
- To prevent of infection in newborn babies (specifically group B streptococcal infection).
- To treat inflammation of brain (meningitis), inflammation of the inner layer of the heart (endocarditis), inflammation of joint (arthritis), gas in tissues (gas gangrene), joint pain caused by parasite ticks (Lyme disease), diphtheria, tetanus, infection from animals (anthrax and leptospirosis), rat-bite fever, actinomycosis (puss filled swelling in the mouth, lungs or gastrointestinal tract caused by actinomyces), listeriosis (infection of central nervous system caused by listeria), pasteurellosis (respiratory disease caused by pasteurella), and sexually transmitted infections (gonorrhea and syphilis).
Novo-Pen G description
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on gamma-aminobutyric acid mediated synaptic transmission.
Novo-Pen G interactions
Anticoagulants (oral and heparin)
May increase bleeding risks of anticoagulant by prolonging bleeding time.
Beta-blockers
May potentiate anaphylactic reactions of penicillin.
Chloramphenicol
May cause synergism or antagonism to develop.
Contraceptives, oral
May reduce efficacy of oral contraceptives.
Erythromycin
May cause synergism or antagonism to develop.
Probenecid
Increases penicillin serum concentration.
Tetracyclines
May impair bactericidal effects of Novo-Pen G.
Incompatibility
Aminoglycosides, parenteral
Penicillin may inactivate aminoglycosides in vitro; do not mix in same IV solution. May be used in combination for synergy if administered separately.
Carbohydrate solutions at alkaline pH
Penicillin solutions are rapidly inactivated.
Laboratory Test Interactions
Antiglobulin (Coombs test)
Drug may cause false-positive results.
Urine glucose test
Drug may cause false-positive results with copper sulfate tests (Benedict test, Fehling test, or Clinitest tablets); enzyme-based tests (eg, Clinistix, Tes-tape ) are not affected.
Urine protein determinations
Drug may cause false-positive reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction, and nitric acid test; bromphenol blue test ( Multi-Stix ) is not affected.
Novo-Pen G side effects
See also:
What are the possible side effects of Novo-Pen G?
Phenoxymethylpenicillin may produce diarrhoea, nausea and heartburn. Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and vasculitis, may occur.
A generalised sensitivity reaction with urticaria, fever, joint pains and eosinophilia can develop within a few hours to several weeks after starting treatment. Superinfection by resistant species, such as Pseudomonas or Candida, which do not respond to penicillin therapy may occur. A sore mouth and a black hairy tongue have been reported.
Increases in liver enzyme values have been reported. Care should be taken when high doses are given to patients with renal impairment (because of the risk of neurotoxicity) or congestive heart failure.
Renal and haematological systems should be monitored during prolonged and high dose therapy.
Care should be taken when treating patients with syphilis, as the Jarisch-Herxheimer reaction may occur shortly after starting treatment. This reaction, manifesting as fever, chills, headache and reactions at the site of the lesion, can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.
Haemolytic anaemia and leucopenia, prolongation of bleeding time and defective platelet function have been observed. Convulsions and other signs of toxicity to the CNS may occur particularly in patients with renal failure.
Disturbances of blood electrolytes may follow the administrations of large doses of this medicine.
High doses should be used with caution in patients receiving potassium containing medicines or potassium-sparing diuretics.
Novo-Pen G contraindications
Hypersensitivity to penicillins. Do not treat severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and purulent or septic arthritis with oral Novo-Pen G during acute stage.
Active ingredient matches for Novo-Pen G:
| Unit description / dosage (Manufacturer) | Price, USD |
| Tablet; Oral; Penicillin G Potassium 500, 000 units | |
List of Novo-Pen G substitutes (brand and generic names): | |
| Mudapenil (Argentina) | |
| Novopen (South Africa) | |
| Ortopen (Spain) | |
| P.P.F | |
| P.P.F 400000IU Injection (Karnataka Antibiotics & Pharmaceuticals Ltd) | $ 0.07 |
| P.P.F(KAA) | |
| P.P.F 400000 IU INJECTION 1 vial / 1 ML injection each (Karnataka Antibiotics & Pharmaceuticals Ltd) | $ 0.07 |
| Pebencil (Venezuela) | |
| Pekamin (Spain) | |
| Pen Aqueous | |
| Injectable; Injection; Penicillin G Procaine 300, 000 units / ml | |
| Pen G (Thailand) | |
| Injectable; Injection; Penicillin G Procaine 300, 000 units / ml | |
| Pen G 1000000 IU x 1's | |
| Pen G 5000000 IU x 1's | |
| Pen Vet | |
| Injectable; Injection; Penicillin G Procaine 300, 000 units / ml | |
| Pen-BGP LA | |
| Injectable; Injection; Penicillin G Benzathine 150, 000 units; Penicillin G Procaine 150, 000 units / ml | |
| Pen-P 1000 | |
| Powder; Oral; Penicillin G Procaine 1, 000 g / kg | |
| Pen-P 110 | |
| Drug Premix; Oral; Penicillin G Procaine 110 g / kg | |
| Pencil 400 (Brazil) | |
| Pencil P (Brazil) | |
| Pencillin G | |
| Pencip (India) | |
| 200000 IU x 6's (Cipla) | $ 0.05 |
| 400000 IU x 6's (Cipla) | $ 0.09 |
| 800000 IU x 4's (Cipla) | $ 0.11 |
| PENCIP tab 200000 IU x 6's (Cipla) | $ 0.05 |
| PENCIP tab 400000 IU x 6's (Cipla) | $ 0.09 |
| PENCIP tab 800000 IU x 4's (Cipla) | $ 0.11 |
| Pencip 200000IU Tablet (Cipla) | $ 0.01 |
| Pencip 400000IU Tablet (Cipla) | $ 0.02 |
| Pencip 800000IU Tablet (Cipla) | $ 0.02 |
| PENCIP(CIP) | |
| PENCIP 200 TABLET 1 strip / 6 tablets each (Cipla Ltd) | $ 0.04 |
| PENCIP 400 TABLET 1 strip / 6 tablets each (Cipla Ltd) | $ 0.09 |
| PENCIP 800 TABLET 1 strip / 4 tablets each (Cipla Ltd) | $ 0.08 |
| Pendiben L-A (Mexico) | |
| Pendure Neat | |
| Injectable; Injection; Penicillin G Benzathine 150, 000 units; Penicillin G Procaine 150, 000 units / ml | |
| Peni G | |
| Injectable; Injection; Benzylpenicillin 500 mg | |
| Injectable; Injection; Benzylpenicillin 1 g | |
| Penibiot Retard (Spain) | |
| Penicil Dermol (Argentina) | |
| Penicillin 10 Mega | |
| Injectable; Injection; Penicillin G Potassium 10 MIU; Penicillin G Sodium | |
| Penicillin Fortified (Israel) | |
| Penicillin G (Bulgaria, Lithuania, Turkey, United States) | |
| Penicillin gk 20 million unit | $ 160.26 |
| Penicillin g na 5 million unit | $ 47.91 |
| Bicillin C-R / 1200000 2ml Syringe | $ 43.00 |
| Penicillin g k 5 million unit | $ 42.18 |
See 210 substitutes for Novo-Pen G | |
References
- DailyMed. "PENICILLIN G SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "penicillin g". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "penicillin g". http://www.drugbank.ca/drugs/DB01053 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Novo-Pen G are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Novo-Pen G. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
