Dosage of Numlo-TM in details
Numlo-TM Dosage
Generic name: Numlo-TM 20mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
2.1 Hypertension
Dosage must be individualized. The usual starting dose of Numlo-TM tablets is 40 mg once a day. Blood pressure response is dose-related over the range of 20 to 80 mg.
Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks. When additional blood pressure reduction beyond that achieved with 80 mg Numlo-TM is required, a diuretic may be added.
No initial dosage adjustment is necessary for elderly patients or patients with renal impairment, including those on hemodialysis. Patients on dialysis may develop orthostatic hypotension; their blood pressure should be closely monitored.
Numlo-TM tablets may be administered with other antihypertensive agents.
Numlo-TM tablets may be administered with or without food.
2.2 Cardiovascular Risk Reduction
The recommended dose of Numlo-TM tablets is 80 mg once a day and can be administered with or without food. It is not known whether doses lower than 80 mg of Numlo-TM are effective in reducing the risk of cardiovascular morbidity and mortality.
When initiating Numlo-TM therapy for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of medications that lower blood pressure may be necessary.
More about Numlo-TM (Numlo-TM)
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Consumer resources
- Numlo-TM
- Numlo-TM (Advanced Reading)
Professional resources
- Numlo-TM (AHFS Monograph)
- Numlo-TM (FDA)
Other formulations
- Numlo-TM HCT
Related treatment guides
- Cardiovascular Risk Reduction
- High Blood Pressure
- Prevention of Cardiovascular Disease
What other drugs will affect Numlo-TM?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Numlo-TM, especially:
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digoxin;
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lithium;
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a diuretic or "water pill";
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NSAIDs (non-steroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, or meloxicam, and others; or
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ramipril or other blood pressure medicines.
This list is not complete. Other drugs may interact with Numlo-TM, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Numlo-TM interactions
Aliskiren: Do not co-administer aliskiren with Numlo-TM in patients with diabetes. Avoid use of aliskiren with Numlo-TM in patients with renal impairment (GFR < 60 mL/min).
Digoxin: When Numlo-TM was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed. Therefore, monitor digoxin levels when initiating, adjusting, and discontinuing Numlo-TM for the purpose of keeping the digoxin level within the therapeutic range.
Lithium: Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists including Numlo-TM. Therefore, monitor serum lithium levels during concomitant use.
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including Numlo-TM, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Numlo-TM and NSAID therapy.
The antihypertensive effect of angiotensin II receptor antagonists, including Numlo-TM may be attenuated by NSAIDs including selective COX-2 inhibitors.
Ramipril and Ramiprilat: Co-administration of Numlo-TM 80 mg once daily and ramipril 10 mg once daily to healthy subjects increases steady-state Cmax and AUC of ramipril 2.3-and 2.1-fold, respectively, and Cmax and AUC of ramiprilat 2.4-and 1.5-fold, respectively. In contrast, Cmax and AUC of Numlo-TM decrease by 31% and 16%, respectively. When co-administering Numlo-TM and ramipril, the response may be greater because of the possibly additive pharmacodynamic effects of the combined drugs, and also because of the increased exposure to ramipril and ramiprilat in the presence of Numlo-TM. Concomitant use of Numlo-TM and ramipril is not recommended.
Other Drugs: Co-administration of Numlo-TM did not result in a clinically significant interaction with acetaminophen, amlodipine, glyburide, simvastatin, hydrochlorothiazide, warfarin, or ibuprofen. Numlo-TM is not metabolized by the cytochrome P450 system and had no effects in vitro on cytochrome P450 enzymes, except for some inhibition of CYP2C19. Numlo-TM is not expected to interact with drugs that inhibit cytochrome P450 enzymes; it is also not expected to interact with drugs metabolized by cytochrome P450 enzymes, except for possible inhibition of the metabolism of drugs metabolized by CYP2C19.
References
- DailyMed. "AMLODIPINE BESYLATE; TELMISARTAN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "U5SYW473RQ: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Angiotensin II Type 1 Receptor Blockers". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Numlo-TM are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Numlo-TM. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
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Information checked by Dr. Sachin Kumar, MD Pharmacology
