What is Omecon D?
Omecon D is a medicine that increases the movements or contractions of the stomach and bowel. Omecon D is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Omecon D is to be given only by or under the immediate supervision of your doctor.
Omecon D indications
Dyspeptic symptom complex often associated with delayed gastric emptying, gastroesophageal reflux disease (GERD) or esophagitis: Epigastric sense of fullness, feeling of abdominal distention, upper abdominal pain, flatulence (gassiness), eructation (belching), and heartburn.
Short-term treatment of nausea and vomiting of various origins including functional, organic, infectious, diabetic origin, or induced by radiotherapy or medicine therapy. (It is not considered suitable for chronic nausea and vomiting, nor for the routine prophylaxis of postoperative vomiting.)
Treatment of nausea and vomiting induced by dopamine agonists ie, L-dopa and bromocriptine used in Parkinson's disease.
Omecon D may also be given as needed, together with paracetamol for the symptomatic treatment of nausea and vomiting associated with migraine.
Uses of Omecon D in details
Omecon D is used to treat vomiting or nausea caused due to indigestion, diseases or drugs. It is also used to relieve fullness of stomach, belching and heavy bloating, gas and heartburn for a longer period up to 2 weeks.
Omecon D description
Omecon D is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K mediated gamma-carboxylation of precursor proteins.
Omecon D dosage
It is recommended to take oral Omecon D before meals. If taken after meals, absorption of the drug is somewhat delayed.
Adults and Adolescents >12 years and weighing ≥35 kg: Tablets: One to two 10-mg tablet 3-4 times/day, with a maximum daily dose of 8 tablets (80 mg).
Oral Suspension:
10-20 mL (of oral susp containing Omecon D 1 mg/mL) 3-4 times/day, with a maximum daily dose of 80 mL.Infants and Children: 0.25-0.5 mg/kg 3-4 times/day with a maximum daily dose of 2.4 mg/kg (but do not exceed 80 mg/day).
Tablets are unsuitable for use in children weighing <35 kg.
Oral Suspension:
0.25-0.5 mg/kg 3-4 times/day with a maximum dose of 2.4 mg/kg (not exceeding 80 mL).Omecon D interactions
The concomitant administration of Omecon D with phenothiazines, butyrophenones and rauwolfia alkaloids may induce the endocrine disturbances or extrapyramidal disorders. If necessary, monitored carefully and administered cautiously.
Should be administered cautiously in patients receiving digitalis preparations.
The concomitant administration of Omecon D with anticholinergic agents may compromise the beneficial effects of Omecon D because of depressing the promoting action of gastrointestinal motility.
Theologically, Omecon D may have an effect on the absorption of oral preparations, especially slow-releasing or enteric-coated preparations because of increasing gastric motility. But in patients stabilized with digoxin or acetaminophen, the concomitant administration of Omecon D had no effect on plasma concentration of these drugs.
It is not reported that Omecon D enhances the effect of neuroleptics.
Omecon D inhibits peripheral adverse reactions eg, dyspepsia, nausea, vomiting, induced by dopamine agonist (eg, bromocriptine, levodopa), but has no effect on central nervous system.
As the concomitant administration of Omecon D with antacids or acid secretion inhibitors lowers biologic activity of Omecon D, these drugs should not be used together.
The actions of Omecon D on gastrointestinal function may be antagonised by antimuscarinics and opioid analgesics.
Omecon D side effects
See also:
What are the possible side effects of Omecon D?
Clinical Trial Data: The safety of Omecon D was evaluated in 1221 patients with gastroparesis, dyspepsia, gastro-oesophageal reflux disorder (GERD) or other related conditions in 45 clinical trials included in the safety database. All patients were ≥15 years and received at least 1 dose of oral Omecon D (Omecon D base). Slightly fewer than one-half (553/1221) of patients were diabetic. The median total daily dose was 80 mg (range 10-160 mg), with 230 patients receiving a dose >80 mg. Median duration of exposure was 56 days (range 1-2248 days).
Adverse drug reactions (ADRs) reported by ≥1% of patients treated with oral Omecon D in these 45 clinical trials (n=1221) are the following: Psychiatric Disorders: Depression (2.5%), anxiety (1.6%), decreased libido/loss of libido (1.5%).
Nervous System Disorders: Headache (5.6%), somnolence (2.5%), akathisia (1%).
Gastrointestinal Disorders: Diarrhoea (5.2%).
Skin and Subcutaneous Tissue Disorders: Rash (2.8%), pruritus (1.7%).
Reproductive System and Breast Disorders: Breast enlargement/gynaecomastia (5.3%), breast tenderness (4.4%), galactorrhoea (3.3%), amenorrhoea (2.9%), breast pain (2.3%), irregular menstruation (2%), lactation disorder (1.6%).
General Disorders and Administration Site Conditions: Asthenia (1.9%).
ADRs that occurred in <1% of Omecon D-treated patients in the 45 clinical trials (n=1221) are the following: Immune System Disorders: Hypersensitivity (0.2%).
Skin and Subcutaneous Disorders: Urticaria (0.7%).
Reproductive System and Breast Disorders: Breast discharge (0.8%), breast swelling (0.5%).
Dry mouth has been reported with over-the-counter use of Omecon D.
Post-Marketing: In addition to the adverse effects reported during clinical studies and previously mentioned, the following adverse drug reactions provided the frequencies according to the following convention: Very common (≥1/10), common (≥1/100 and <1/10); uncommon (≥1/1000 and <1/100); rare (≥1/10,000 and <1/1000); very rare (<1/10,000, including isolated reports).
The following ADRs are presented by frequency category based on spontaneous reporting rates: Immune System Disorders: Very Rare: Anaphylactic reactions (including anaphylactic shock).
Psychiatric Disorders: Very Rare: Agitation, nervousness.
Nervous System Disorders: Very Rare: Extrapyramidal disorder, convulsion.
Cardiac Disorders: Very Rare: Sudden cardiac death*, serious ventricular arrhythmias*.
Skin and Subcutaneous Tissue Disorders: Very Rare: Angioedema.
Renal and Urinary Disorders: Very Rare: Urinary retention.
Investigations: Very Rare: Abnormal liver function test; increased blood prolactin.
Note: *Based on epidemiology data (as follows).
As the hypophysis is outside the blood-brain barrier, Omecon D may cause an increase in prolactin levels. In rare cases, this hyperprolactinaemia may lead to neuro-endocrinological side effects eg, galactorrhoea, gynaecomastia and amenorrhoea.
Extrapyramidal disorder occurs primarily in neonates and infants.
Other central nervous system-related effects of convulsion and agitation are also reported primarily in infants and children.
An increase in the risk of serious ventricular arrhythmias and sudden cardiac death has been reported in some epidemiology studies. Due to the limitations of these data, risk factors and the exact frequency of these adverse reactions could not be defined.
Omecon D contraindications
Hypersensitivity to Omecon D or any ingredient of Omecon D.
If patients are taking oral ketoconazole, fluconazole, voriconazole, erythromycin, clarithromycin, telithromycin, amiodarone, selective serotonin reuptake inhibitors, HIV protease inhibitors, calcium antagonists which can increase plasma concentrations of Omecon D, leading to a prolonged QTc interval. These medicines can increase plasma concentrations of Omecon D leading to a prolonged QTc interval. Patients with long QT syndrome develop a very fast heart rhythm disturbance leading to a sudden loss of consciousness.
Gastrointestinal hemorrhage (bleeding), obstruction, perforation or conditions where gastrointestinal stimulation or movements may be dangerous.
Prolactin-releasing pituitary tumor (prolactinoma).
Active ingredient matches for Omecon D:
| Unit description / dosage (Manufacturer) | Price, USD |
| Omecon D 20+10 Capsule | $ 0.05 |
| OMECON D 10MG/20MG CAPSULE 1 strip / 10 capsules each (Icon Pharma & Surgicals Pvt Ltd) | $ 0.48 |
| Omecon D Capsule (Icon Pharma & Surgicals Pvt Ltd) | $ 0.05 |
List of Omecon D substitutes (brand and generic names): | |
| Omecon | |
| Omecon 20mg Capsule (Icon Pharma & Surgicals Pvt. Ltd) | $ 0.04 |
| OMECOOL | |
| OMECOOL 20MG CAPSULE 1 strip / 15 capsules each (Shreya Life Sciences Pvt Ltd) | $ 0.78 |
| OMECOS (India) | |
| 20 mg x 200's (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 9.64 |
| Omecos 20mg TAB / 10 (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | |
| Omecos 20 mg Capsule (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 0.05 |
| Omecos 20mg CAP / 200 (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 9.64 |
| OMECOS cap 20 mg x 10's (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 0.48 |
| Omecos 20mg CAP / 200 (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 9.64 |
| Omecos D | |
| Omecos D 20+10 Capsule (Coastal (Symbiosis Pharmaceuticals Pvt Ltd)) | $ 0.06 |
| Omecyg DR | |
| Omecyg DR 20 mg Tablet (Talent Laboratories) | $ 0.04 |
| Omed (Philippines, South Korea) | |
| Tablet, Film-Coated; Oral; Omeprazole 20 mg (Almed Drugs (P) Ltd.) | |
| Omed 20 mg x 2 x 10's (Almed Drugs (P) Ltd.) | $ 19.84 |
| Capsules; Oral; Omeprazole 20 mg (Almed Drugs (P) Ltd.) | |
| Tablets, Film-Coated; Oral; Omeprazole 20 mg (Almed Drugs (P) Ltd.) | |
| Omed 20 mg Tablet (Almed Drugs (P) Ltd.) | $ 0.02 |
| Omed 20 mg Dynamic Labs Tablet (Almed Drugs (P) Ltd.) | $ 0.02 |
| Omed 20 (Philippines) | |
| Omed 20 20 mg x 24's | |
| Omed antacid (Switzerland) | |
| Omed antacid Sandoz (Switzerland) | |
| Omed antacid Sandoz 20mg (Switzerland) | |
| OMED LB | |
| OMED LB TABLET 1 strip / 10 tablets each (Medicross Pharmaceuticals) | $ 0.57 |
| OMED(PAJ) | |
| OMED CAPSULE 1 strip / 10 capsules each (Panjon Pharma Ltd) | $ 0.57 |
| Omed/Omed 20 (Philippines) | |
| Omed 20 cap 20 mg 24's (Medhaus) | |
| Omedar (Oman, Romania) | |
| Omedate | |
| Omedate 20 mg Tablet (Biosearch Organics (Ultramark Healthcare Pvt Ltd) | $ 0.04 |
| Omeday (India) | |
| Omeday 20 mg Capsule (Bio Vitamins Pvt Ltd.) | $ 0.05 |
| OMEDAY 20MG CAPSULE 1 strip / 10 capsules each (Bio Vitamins Pvt Ltd.) | $ 0.72 |
| OMEDAY 20MG CAPSULE 1 strip / 15 capsules each (Bio Vitamins Pvt Ltd.) | $ 0.72 |
| OMEDAY cap 20 mg x 15's (Bio Vitamins Pvt Ltd.) | $ 0.72 |
| OMEDAY D | |
| OMEDAY D 30MG CAPSULE 1 strip / 10 capsules each (Bio Vitamins) | $ 0.59 |
| Omedec (Ecuador) | |
| Omeder (India) | |
| Omeder 20 mg Capsule (Wonder Healthcare) | $ 0.05 |
| OMEDER cap 20 mg x 10's (Wonder Healthcare) | $ 0.36 |
| Omeder D | |
| Omeder D 20+10 Capsule (Wonder Healthcare) | $ 0.07 |
| Omeder DSR | |
| Omeder DSR 20+30 Capsule (Wonder Healthcare) | $ 0.09 |
| Omediprol (Estonia) | |
| Omedoc (Germany) | |
| Omedone | |
| Omedone 20+10 Capsule (Allied Chemicals & Pharmaceuticals Pvt.Ltd.) | $ 0.05 |
| Omedone 20+10 BL Pharma Tablet (Allied Chemicals & Pharmaceuticals Pvt.Ltd.) | $ 0.05 |
| Omedy | |
| Omedy 20 mg Capsule (Zedip Formulations) | $ 0.03 |
| Omedy D | |
| Omedy D 20+10 Capsule (Zedip Formulations) | $ 0.04 |
| Omee | |
| Omee 20mg CAP / 15 | $ 0.75 |
See 7429 substitutes for Omecon D | |
References
- DailyMed. "OMEPRAZOLE MAGNESIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "omeprazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "domperidone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Omecon D are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Omecon D. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
