• Dosage of Ophtosan in details
• Ophtosan interactions
• Ophtosan reviews

Dosage of Ophtosan in details

Ophtosan Dosage

Medically reviewed by Drugs.com. Last updated on Dec 14, 2018.

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• Side Effects
• Dosage
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Applies to the following strengths: 10000 intl units; 25000 units; 50000 units/mL; 50000 units; 8000 units

Usual Adult Dose for:

• Ophtosan Deficiency
• Vitamin/Mineral Supplementation

Usual Pediatric Dose for:

• Ophtosan Deficiency
• Vitamin/Mineral Supplementation

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis

Usual Adult Dose for Ophtosan Deficiency

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Ophtosan deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Adult Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

Adult male: 900 mcg retinol activity equivalents (RAE) (3000 international units [IU])

Tolerable Upper Intake Level (UL): 3000 mcg RAE (10,000 IU)

Adult female: 700 mcg RAE (2330 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Ophtosan RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Ophtosan into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Usual Pediatric Dose for Ophtosan Deficiency

Infants (under 1 year): 7500 to 15,000 Units intramuscularly once a day

Duration of therapy: 10 days

1 to 8 years: 17,500 to 35,000 Units intramuscularly once a day

Duration of therapy: 10 days

Adult dose:

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Ophtosan deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Pediatric Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

0 to 6 months: 400 mcg retinol activity equivalents (RAE) (1332 international units [IU])

Tolerable Upper Intake Level (UL): 600 mcg RAE (2000 IU)

7 to 12 months: 500 mcg RAE (1665 IU)

UL: 600 mcg RAE (2000 IU)

1 to 3 years: 300 mcg RAE (1000 IU)

UL: 900 mcg RAE (3000 IU)

4 to 8 years: 400 mcg RAE (1332 IU)

UL: 900 mcg RAE (3000 IU)

9 to 13 years: 600 mcg RAE (2000 IU)

UL: 1700 mcg RAE (5667 IU)

14 to 18 years, male: 900 mcg RAE (3000 IU)

UL: 2800 mcg RAE (9333 IU)

14 to 18 years, female: 700 mcg RAE (2330 IU)

UL: 2800 mcg RAE (9333 IU)

Comments:

-The Ophtosan RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Ophtosan into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

US Recommended Dietary Allowance (RDA):

Pregnancy:

14 to 18 years: 750 mcg retinol activity equivalents (RAE) (2500 international units [IU])

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 770 mcg RAE (2564 IU)

UL: 3000 mcg RAE (10,000 IU)

Lactation:

14 to 18 years: 1200 mcg RAE (2564 IU)

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 1300 mcg RAE (4329 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Ophtosan RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Ophtosan into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Precautions

CONTRAINDICATIONS:

-Administration of the intramuscular formulation intravenously

-Hypervitaminosis A

-Hypersensitivity to any of the ingredients

-The safety of doses exceeding 6000 units Ophtosan in pregnancy has not been established. Use of high doses in pregnancy or patients who may become pregnant is contraindicated. Doses above the recommended dietary allowance (RDA) may cause fetal harm; fetal abnormalities (central nervous system, eye, and palate malformations) were seen in animal overdose models. If patients become pregnant, apprise them of potential fetal harms.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

More about Ophtosan

• Side Effects
• During Pregnancy
• Drug Interactions
• En Español
• Drug class: vitamins

Consumer resources

• Ophtosan
• Ophtosan Tablets and Capsules
• Ophtosan Injection
• Ophtosan

  Oral,

  Intramuscular (Advanced Reading)

Other brands: Aquasol A, Ophtosan, A/Fish Oil

Professional resources

• Ophtosan (AHFS Monograph)
• ... +1 more

Related treatment guides

• Ophtosan Deficiency

What other drugs will affect Ophtosan?

Do not take Ophtosan without your doctor's advice if you are also taking:

• birth control pills;

• a blood thinner such as warfarin (Coumadin, Jantoven);

• bexarotene (Targretin);

• cholestyramine (Questran, Prevalite);

• acitretin (Soriatane);

• tretinoin (Vesanoid); or

• isotretinoin (Accutane, Sotret, Claravis, Amnesteem).

This list is not complete and other drugs may interact with Ophtosan. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Ophtosan interactions

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this vitamin include: acitretin, alitretinoin, bexarotene, cholestyramine, isotretinoin, tretinoin, other products that contain Ophtosan (such as multivitamins), warfarin.

Avoid taking Ophtosan at the same time as you take neomycin, orlistat, and mineral oil. If you take any of these medications, separate your doses from your dose of Ophtosan by at least 2 hours.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Reviews

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Information checked by Dr. Sachin Kumar, MD Pharmacology