Actions of Ospenine 500 in details
Description: Ospenine 500 inhibits the final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane, thus inhibiting bacterial cell wall synthesis. It may be less active against some susceptible organisms, particularly gm-ve bacteria. It is suitable for mild to moderate infections.
Pharmacokinetics:
Absorption: Rapidly but incompletely absorbed (approx 60%) from the GI tract. Absorption is slightly affected by the presence of food. Bioavailability: Approx 60%. Time to peak plasma concentrations: 30-60 min.
Distribution: Widely distributed into body tissues. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 80%.
Metabolism: Undergoes hepatic metabolism. Several metabolites have been identified, including penicilloic acid.
Excretion: Via urine (as unchanged drug and metabolites) and bile (small amounts). Plasma half-life: Approx 30-60 min.
Ospenine 500 administration
Ospenine 500: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Ospenine 500 pharmacology
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ospenine 500 inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ospenine 500 interferes with an autolysin inhibitor.
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Information checked by Dr. Sachin Kumar, MD Pharmacology