Actions of Oxatomide Nichi-iko in details
Description: Oxatomide Nichi-iko is a piperazine derivative sedating antihistamine. It also has mast-cell stabilising properties.
Pharmacokinetics:
Absorption: Almost completely absorbed from the GI tract. Peak plasma levels within 2 hr.
Distribution: Protein-binding: 98%.
Metabolism: Hepatic via aromatic hydroxylation, oxidative N-dealkylation and conjugation.
Excretion: Mainly via faeces (60%) from the bile; via urine. Half-life: 14 hr.
Oxatomide Nichi-iko administration
Should be taken with food. Take after meals.
Oxatomide Nichi-iko pharmacology
Oxatomide Nichi-iko is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
References
- EPA DSStox. "Oxatomide: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
