What is Périndopril?
Périndopril is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Périndopril works by blocking a substance in the body that causes the blood vessels to tighten. As a result, Périndopril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Périndopril is also used in patients with coronary artery disease to prevent heart attacks.
Périndopril is available only with your doctor's prescription.
Périndopril indications
Hypertension
Périndopril erbumine is indicated for the treatment of patients with essential hypertension. Périndopril erbumine may be used alone or given with other classes of antihypertensives, especially thiazide diuretics.
Stable Coronary Artery Disease
Périndopril erbumine is indicated for treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction. Périndopril erbumine can be used with conventional treatment for management of coronary artery disease, such as antiplatelet, antihypertensive or lipid-lowering therapy.
How should I use Périndopril?
Use Périndopril as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Périndopril by mouth with or without food.
- Take Périndopril on a regular schedule to get the most benefit from it.
- Taking Périndopril at the same time(s) each day will help you to remember to take it.
- Continue taking Périndopril even if you feel well. Do not miss any doses.
- If you miss a dose of Périndopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Périndopril.
Uses of Périndopril in details
Périndopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to prevent heart attacks in patients with a certain type of heart disease (stable coronary artery disease).
Périndopril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to treat congestive heart failure and to help protect the kidneys from damage due to diabetes.
How to use Périndopril
Take this medication by mouth as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment.
To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
It may take several weeks before you get the full benefit of this drug.
Tell your doctor if your condition does not get better or if it gets worse (for example, your blood pressure readings remain high or increase).
Périndopril description
Périndopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Périndopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
Périndopril dosage
Périndopril Dosage
Generic name: Périndopril erbumine 2mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Hypertension
Use in Uncomplicated Hypertensive Patients: In patients with essential hypertension, the recommended initial dose is 4 mg once a day. The dose may be titrated, as needed to a maximum of 16 mg per day. The usual maintenance dose range is 4 mg to 8 mg administered as a single daily dose or in two divided doses.
Use in Elderly Patients: The recommended initial daily dosage of Périndopril for the elderly is 4 mg daily, given in one or two divided doses. Experience with Périndopril is limited in the elderly at doses exceeding 8 mg. Dosages above 8 mg should be administered with careful blood pressure monitoring and dose titration.
Use with Diuretics: In patients who are currently being treated with a diuretic, symptomatic hypotension can occur following the initial dose of Périndopril. Consider reducing the dose of diuretic prior to starting Périndopril.
Stable Coronary Artery Disease
In patients with stable coronary artery disease, Périndopril should be given at an initial dose of 4 mg once daily for 2 weeks, and then increased as tolerated, to a maintenance dose of 8 mg once daily. In elderly patients (greater than 70 years), Périndopril should be given as a 2 mg dose once daily in the first week, followed by 4 mg once daily in the second week and 8 mg once daily for maintenance dose if tolerated.
Dose Adjustment in Renal Impairment and Dialysis
Perindoprilat elimination is decreased in renally impaired patients. Périndopril is not recommended in patients with creatinine clearance <30 mL/min. For patients with lesser degrees of impairment, the initial dosage should be 2 mg/day and dosage should not exceed 8 mg/day. During dialysis, Périndopril is removed with the same clearance as in patients with normal renal function.
More about Périndopril (Périndopril)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
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- Support Group
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- Generic Availability
Consumer resources
- Périndopril
- Périndopril (Advanced Reading)
Professional resources
- Périndopril (AHFS Monograph)
- Périndopril (FDA)
Related treatment guides
- Coronary Artery Disease
- Diabetic Kidney Disease
- Heart Attack
- Heart Failure
- High Blood Pressure
- More (1) »
Périndopril interactions
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What other drugs will affect Périndopril?
you should check with your doctor if you are taking any of the following to
be sure that it is safe to take this medicine at the same time:
• other medicines for treating high blood pressure including diuretics
(water tablets);
• potassium-sparing diuretics (eg spironolactone, triamterene or
amiloride); potassium supplements and potassium-containing salt
substitutes;
• medicines for the treatment of diabetes (insulin or tablets) to lower
blood sugar;
• lithium for mania or depression;
• medicines for the treatment of mental disorders such as depression,
anxiety, schizophrenia or other psychoses;
Read all of this leaflet carefully before you start taking
this medicine.
• Keep this leaflet. You may need to read it again.
• If you have further questions, please ask your doctor or
pharmacist.
• This medicine has been prescribed for you personally and
you should not pass it on to others. It may harm them, even
if their symptoms are the same as yours.
Périndopril 2mg TABLETS
Périndopril tert-butylamine salt
Périndopril 4mg TABLETS
Périndopril tert-butylamine salt
Périndopril 8mg TABLETS
Périndopril tert-butylamine salt
• allopurinol used for the treatment of gout;
• immunosuppressants used for the treatment of auto-immune
disorders (eg rheumatoid arthritis) or following transplant surgery;
• procainamide, a treatment for irregular heartbeat;
• non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief,
including aspirin;
• medicines used for the treatment of low blood pressure, shock or
asthma (eg ephedrine, noradrenaline or adrenaline);
• vasodilators including nitrates (products that make the blood
vessels become wider);
• heparin (used to thin the blood).
Ask your doctor if you are not sure what these medicines are.
Périndopril side effects
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What are the possible side effects of Périndopril?
Because clinical trials are conducted under widely varying conditions, adverse event rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Clinical Trials Experience
The following adverse reactions are discussed elsewhere in labeling:
- •
- Anaphylactoid reactions, including angioedema
- •
- Hypotension
- •
- Neutropenia and agranulocytosis
- •
- Impaired renal function
- •
- Hyperkalemia
- •
- Cough
Périndopril has been evaluated for safety in approximately 3,400 patients with hypertension in U.S. and foreign clinical trials. The data presented here are based on results from the 1,417 Périndopril-treated patients who participated in the U.S. clinical trials. Over 220 of these patients were treated with Périndopril for at least one year.
In placebo-controlled U.S. clinical trials, the incidence of premature discontinuation of therapy due to adverse events was 6.5% in patients treated with Périndopril and 6.7% in patients treated with placebo. The most common causes were cough, headache, asthenia and dizziness.
Among 1,012 patients in placebo-controlled U.S. trials, the overall frequency of reported adverse events was similar in patients treated with Périndopril and in those treated with placebo (approximately 75% in each group). The only adverse events whose incidence on Périndopril was at least 2% greater than on placebo were cough (12% vs. 4.5%) and back pain (5.8% vs. 3.1%).
Dizziness was not reported more frequently in the Périndopril group (8.2%) than in the placebo group (8.5%), but its likelihood increased with dose, suggesting a causal relationship with Périndopril.
Stable Coronary Artery Disease
Périndopril has been evaluated for safety in EUROPA, a double-blind, placebo-controlled study in 12,218 patients with stable coronary artery disease. The overall rate of discontinuation was about 22% on drug and placebo. The most common medical reasons for discontinuation that were more frequent on Périndopril than placebo were cough, drug intolerance and hypotension.
Postmarketing Experience
Voluntary reports of adverse events in patients taking Périndopril that have been received since market introduction and are of unknown causal relationship to Périndopril include: cardiac arrest, eosinophilic pneumonitis, neutropenia/agranulocytosis, pancytopenia, anemia (including hemolytic and aplastic), thrombocytopenia, acute renal failure, nephritis, hepatic failure, jaundice (hepatocellular or cholestatic), symptomatic hyponatremia, bullous pemphigoid, pemphigus, acute pancreatitis, falls, psoriasis, exfoliative dermatitis and a syndrome which may include: arthralgia/arthritis, vasculitis, serositis, myalgia, fever, rash or other dermatologic manifestations, a positive antinuclear antibody (ANA), leukocytosis, eosinophilia or an elevated erythrocyte sedimentation rate (ESR).
Clinical Laboratory Test Findings
HematologySmall decreases in hemoglobin and hematocrit occur frequently in hypertensive patients treated with Périndopril, but are rarely of clinical importance. In controlled clinical trials, no patient was discontinued from therapy due to the development of anemia. Leukopenia (including neutropenia) was observed in 0.1% of patients in U.S. clinical trials.
Liver Function Tests
Elevations in ALT (1.6% Périndopril versus 0.9% placebo) and AST (0.5% Périndopril versus 0.4% placebo) have been observed in placebo-controlled clinical trials. The elevations were generally mild and transient and resolved after discontinuation of therapy.
Périndopril contraindications
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What is the most important information I should know about Périndopril?
Hypersensitivity to Périndopril or to any of the excipients of Périndopril or to any other ACE inhibitor; history of angioedema associated with previous ACE inhibitor therapy; hereditary or idiopathic angioedema.
Due to the presence of lactose, patients with rare hereditary problems of galactose intolerance, glucose-galactose malabsorption, or the Lapp lactase deficiency should not take Périndopril.
Use in pregnancy: Périndopril should not be used during the 1st trimester of pregnancy. When a pregnancy is planned or confirmed, the switch to an alternative treatment should be initiated as soon as possible. Controlled studies with ACE inhibitors have not been done in humans, but in a limited number of cases with 1st trimester exposure, there do not appear to have been any malformations consistent with human foetotoxicity as described as follows.
Périndopril is contraindicated during the 2nd and 3rd trimesters of pregnancy.
Prolonged ACE inhibitor exposure during the 2nd and 3rd trimesters is known to induce human foetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia).
Should exposure to Périndopril have occurred from the 2nd trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Active ingredient matches for Périndopril:
Périndopril
| Unit description / dosage (Manufacturer) | Price, USD |
| Tablet; Oral; Perindopril Erbumine 4 mg | |
| Tablet; Oral; Perindopril Erbumine 8 mg | |
| Tablet; Oral; Perindopril Erbumine 2 mg | |
| Aceon 8 mg tablet | $ 3.14 |
| Perindopril erbumine 8 mg tablet | $ 2.80 |
| Aceon 4 mg tablet | $ 2.58 |
| Perindopril erbumine 4 mg tablet | $ 2.30 |
| Aceon 2 mg tablet | $ 2.22 |
| Perindopril erbumine 2 mg tablet | $ 1.98 |
| Coversyl 8 mg Tablet | $ 1.23 |
| Coversyl 4 mg Tablet | $ 0.88 |
| Coversyl 2 mg Tablet | $ 0.70 |
List of Périndopril substitutes (brand and generic names): | |
| Prestpril (Romania) | |
| Prexanil (Croatia (Hrvatska), Czech Republic, Estonia, Serbia, Slovenia) | |
| Prexanil A (Croatia (Hrvatska)) | |
| Prexanil Combi A (Croatia (Hrvatska)) | |
| Prexum (Indonesia, South Africa) | |
| Pricoron (Czech Republic, Romania) | |
| Prilam (Georgia) | |
| Prindace (Ireland) | |
| Prindex (Bulgaria, Estonia, Latvia, Lithuania, Romania) | |
| Syrup; Oral; Carbinoxamine Maleate 25 mg; Pseudoephedrine Hydrochloride 60 mg / 5 ml (Medicamenta) | |
| Tablet, Film-Coated; Oral; Carbinoxamine Maleate 2.5 mg; Pseudoephedrine Hydrochloride 60 mg (Medicamenta) | |
| Prinopril (Bulgaria) | |
| Pritnox (Poland) | |
| Procaptan (Italy) | |
| Provinace (Malaysia) | |
| Provinace 4 mg x 3 Blister x 10 Tablet | |
| Provinace 4 mg x 30's | |
| Ran-Perindopril (South Africa) | |
| Ranbapril (Serbia) | |
| Relika (Croatia (Hrvatska)) | |
| Revosyl 8 | |
| Rindolex (Slovenia) | |
| Serperil (Turkey) | |
| Spec Perindopril (South Africa) | |
| Spopress (Poland) | |
| Stoppress (Romania) | |
| Stopress (Bulgaria, Estonia, Latvia, Lithuania) | |
| Terc-butilaminijev (Slovenia) | |
| Terry White Chemists Perindopril (Australia) | |
| Tablet; Oral; Perindopril Erbumine 2 mg | |
| Tablet; Oral; Perindopril Erbumine 4 mg | |
| Tablet; Oral; Perindopril Erbumine 8 mg | |
| Terry White Chemists Perindopril Arginine (Australia) | |
| Trezen (Romania) | |
| Vectoryl (South Africa) | |
| Versil (Bangladesh) | |
| Versil 6 mg Tablet (Silver Biotech (Sanify Healthcare Pvt. Ltd.)) | $ 0.18 |
| Vidotin (Czech Republic, Estonia, Latvia, Lithuania, Poland, Romania) | |
| Vidotin 4 mg (Hungary) | |
| Vidotin 8 mg (Hungary) | |
| Viritin (Vietnam) | |
| Viritin 4 (Vietnam) | |
| Viritin 4 4 mg x 1 Blister x 30 Tablet | |
| Zimpril | |
| Zimpril 4mg Tablet (Zee Laboratories) | $ 0.10 |
| Zimpril 8mg Tablet (Zee Laboratories) | $ 0.17 |
| Zydus Perindopril (South Africa) | |
See 484 substitutes for Périndopril | |
References
- PubChem. "PERINDOPRIL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "PERINDOPRIL". http://www.drugbank.ca/drugs/DB00790 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
