What happens if I overdose Panaflex?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Panaflex patch may be harmful if swallowed.
Proper storage of Panaflex patch:
Store Panaflex patch at 77 degrees F (25 degrees C) in the sealed pouch. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Throw away any unused patches 3 months after opening the pouch. The pouch is not child-resistant. Keep Panaflex patch out of the reach of children and away from pets.
Overdose of Panaflex in details
Symptoms: There is no typical clinical picture resulting from Panaflex overdosage. Overdosage can cause symptoms such as vomiting, gastrointestinal hemorrhage, diarrhea, dizziness, tinnitus or convulsions. In the event of significant poisoning, acute renal failure and liver damage are possible.
Therapeutic Measures: Management of acute poisoning with NSAIDs, including Panaflex, essentially consists of supportive measures and symptomatic treatment. Supportive measures and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal disorder, and respiratory depression.
Special measures such as forced diuresis, dialysis, or hemoperfusion are probably of no help in eliminating NSAIDs, including Panaflex, due to the high protein binding and extensive metabolism.
Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination (e.g. vomiting, gastric lavage) after ingestion of a potentially life-threatening overdose.
Gastro-Resistant/SR Tablets: Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination (e.g. vomiting, gastric lavage) after ingestion of a potentially life-threatening overdose.
What should I avoid while taking Panaflex?
Ask a doctor or pharmacist before using any cold, allergy, or other pain medicine. Medicines similar to Panaflex are contained in many combination medicines. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid exposure to sunlight or tanning beds. Panaflex can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Panaflex warnings
Panaflex should be used cautiously with the elderly. In patients with congestive heart failure, hypertension, decreased renal, or hepatic function, history of gastrointestinal disease or those receiving anticoagulants.
Panaflex 50 DT is recommended for short-term treatment only.
Use in Pregnancy and Lactation:
Panaflex should not be used during pregnancy particularly the last three months owing to the possibility of uterine inertia and/or premature closure of the ductus arteriosus.
Panaflex is excreted in breast milk, but in quantities so small that no undesirable effects on the infant are to be expected.
Management of acute poisoning with NSAIDs consists essentially of supportive and symptomatic measures. There is no typical clinical picture associated with overdosage of Panaflex.
The following therapeutic measures should be taken in cases of overdosage:
Absorption should be prevented as soon as possible after the overdosage by means of gastric lavage and treatment with activated charcoal.
Supportive and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal irritation and respiratory depression.
Specific therapy such as forced diuresis, dialysis or haemoperfusion is unlikely to be helpful in accelerating the elimination of NSAIDs because of their high protein binding rate and extensive metabolism.
What should I discuss with my healthcare provider before taking Panaflex?
Panaflex can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking Panaflex.
Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Panaflex may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Panaflex, especially in older adults.
You should not use Panaflex if you are allergic to Panaflex, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
To make sure Panaflex is safe for you, tell your doctor if you have:
-
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
-
a history of heart attack, stroke, or blood clot;
-
a history of stomach ulcers or bleeding;
-
asthma;
-
liver or kidney disease;
-
fluid retention.
Taking Panaflex during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether Panaflex passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Panaflex is not approved for use by anyone younger than 18 years old.
Panaflex precautions
Deterioration in renal function has been attributed to the concomitant use of Panaflex and triamterene and to the concomitant use of Panaflex and cyclosporin.
Panaflex sodium has been associated with clinical exacerbation of porphyria and is considered unsafe in porphyric patients.
Use in pregnancy & lactation: In late pregnancy, Panaflex should, as with other NSAIDs, be avoided because it will cause premature arteriosus. The effect of Panaflex on labor and delivery in pregnant women are unknown. Because of the known effects of prostaglandin-inhibiting drugs on the fetal cardiovascular system (closure of ductus arteriosus), use of Panaflex during late pregnancy should be avoided and as with other NSAIDs, it is possible that Panaflex may inhibit uterine contractions and delay parturition.
Because of the potential of serious adverse reactions in nursing infants from Panaflex, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
What happens if I miss a dose of Panaflex?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).
- MeSH. "Cyclooxygenase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
