Overdose of Panoprist in details
The most likely adverse event in case of overdose is hypotension, with clinical possibility of nausea, vomiting, hypotension in Panoprist 5 mg, cramps, dizziness, sleepiness, mental confusion, polyuria or oliguria which may progress to anuria (due to hypovolaemia). Salt and water disturbances (low sodium levels, low potassium levels) may occur.
The first measures to be taken consist of rapid elimination of the products ingested by gastric lavage and/or administration of activated charcoal, then restoration of fluid and electrolyte balance in a specialised centre until they return to normal.
If marked hypotension occurs, this can be treated by placing the patient in a supine position with the head lowered. If necessary, an IV infusion of isotonic saline may be given, or any other method of volaemic expansion may be used.
Perindoprilate, the active form of Perindopril (Panoprist), can be dialysed.
Panoprist warnings
Take special care with this medicine If any of the following apply to you please talk to your doctor before taking this medicine:
* if you have aortic stenosis (narrowing of the main blood vessel leading from the heart)
or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing
of the artery supplying the kidney with blood),
* if you have any other heart problems or problems with your kidneys,
* if you have liver problems,
* if you suffer from a collagen disease (skin disease) such as systemic lupus erythematosus
or scleroderma,
* if you have atherosclerosis (hardening of the arteries),
PACKAGE LEAFLET: INFORMATION FOR THE USER
Read all of this leaflet carefully before you start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them,
even if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
Perindopril (Panoprist) arginine / Indapamide (Panoprist) Film-coated tablets
2
* if you suffer from hyperparathyroidism (overactive parathyroid gland),
* if you suffer from gout,
* if you have diabetes,
* if you are on a salt restricted diet or use salt substitutes which contain potassium,
* if you take lithium or potassium-sparing diuretics (spironolactone, triamterene) as their use
with this medicine should be avoided (see “Taking other
medicines”).
You must tell your doctor if you think that you are (or might become) pregnant. this medicine is not recommended in early pregnancy, and must not be taken
if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at
that stage.
When you are taking this medicine, you should also inform your
doctor or the medical staff:
* if you are to undergo anaesthesia and/or surgery,
* if you have recently suffered from diarrhoea or vomiting, or are dehydrated,
* if you are to undergo dialysis or LDL apheresis (which is removal of cholesterol from your blood by a machine),
* if you are going to have desensitisation treatment to reduce the effects of an allergy to bee
or wasp stings,
* if you are to undergo a medical test that requires injection of an iodinated contrast agent
(a substance that makes organs like kidney or stomach visible on an X-ray)
Athletes should be aware that this medicine contains an active
ingredient (Indapamide (Panoprist)) which may give a positive reaction in drug tests.
this medicine should not be given to children.
Panoprist precautions
Aortic stenosis or hypertrophic cardiomyopathy or renal artery stenosis. Other heart, kidney or liver problems; collagen disease eg, systemic lupus erythematosus or scleroderma; atherosclerosis; hyperparathyroidism; gout; diabetes; on salt-restricted diet or salt substitutes containing potassium. Avoid use in those taking lithium or potassium-sparing diuretics.
The physician should be informed in the following instances: Those who will undergo anesthesia and/or surgery; recently suffered from diarrhea or vomiting or dehydrated; undergo dialysis or LDL apheresis; desensitization treatment to reduce the effects of an allergy to bee or wasp stings; medical test that will require injection of an iodinated contrast agent.
Athletes should be aware that Panoprist contains Indapamide (Panoprist) which may give a positive reaction in drug tests.
Panoprist contains lactose. Physician should be informed if there is intolerance to sugar.
Effects on the Ability to Drive or Operate Machinery: Panoprist does not usually affect alertness but different reactions eg, dizziness or weakness in relation to the decrease in blood pressure may occur in certain patients. If affected, the ability to drive or operate machinery may be impaired.
References
- DailyMed. "INDAPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "indapamide". http://www.drugbank.ca/drugs/DB00808 (accessed September 17, 2018).
- DrugBank. "PERINDOPRIL". http://www.drugbank.ca/drugs/DB00790 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
