Pencillin 625 indications
Oral
Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
Adult: 125-250 mg 6-8 hrly for 10 days.
Oral
Fusospirochetosis (Vincent's infection) of the oropharynx, Staphylococcal infections of the skin and soft tissue
Adult: 250-500 mg 6-8 hrly.
Oral
Pneumococcal infections of the respiratory tract, including otitis media
Adult: 250-500 mg 6 hrly until the patient is afebrile for at least 2 days.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Prophylaxis of recurrent rheumatic fever
Adult: 250 mg bid.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Susceptible infections
Adult: 250-500 mg 6 hrly.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Pencillin 625 description
Pencillin 625 (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Pencillin 625 dosage
Adults: 250-500 mg every 6 hrs.
Children: Suggested dosage for infants and children is 50 mg/kg body weight/day in 4 divided doses. To be given every 6 hrs.
Children 7-12 years: 5-10 mL (1-2 tsp) of Pencillin 625 250 mg/5 mL; 3-6 years: 5-10 mL (1-2 tsp) of Pencillin 625 125 mg/5 mL or 5 mL (1 tsp) of Pencillin 625 250 mg/5 mL; 1-2 years: 5 mL (1 tsp) of Pencillin 625 125 mg/5 mL or 2.5-5 mL of Pencillin 625 250 mg/5 mL.
Usual duration of therapy is from 10-14 days. Or as prescribed by the physician.
Pencillin 625 interactions
Pencillin 625 should not be combined with bacteriostatic antibiotics. Combinations with other antibiotics should be considered if their effects can be expected to be synergistic or at least additive. The combination partners should be fully dosed. (Exception: In combination with a proven synergistic action, the dose of the more toxic combination partner may be reduced.) Competitive inhibition of drug elimination should be remembered, whenever anti-inflammatories, antirheumatics, antipyretics (particularly indomethacin, phenylbutazone, salicylates in high doses) or probenecid are used concomitantly. Ingestion of Pencillin 625 with meals reduce the absorption of the drug. Like other antibiotics, Pencillin 625 may reduce the efficacy of oral contraceptives. During treatment with Pencillin 625 non-enzymatic urinary glucose tests and uribilinogen tests may be false-positive. Urinary amino acid quantitations with ninhydrin may also be false-positive.
Pencillin 625 side effects
Pencillin 625 may produce diarrhoea, nausea and heartburn. Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and vasculitis, may occur.
A generalised sensitivity reaction with urticaria, fever, joint pains and eosinophilia can develop within a few hours to several weeks after starting treatment. Superinfection by resistant species, such as Pseudomonas or Candida, which do not respond to penicillin therapy may occur. A sore mouth and a black hairy tongue have been reported.
Increases in liver enzyme values have been reported. Care should be taken when high doses are given to patients with renal impairment (because of the risk of neurotoxicity) or congestive heart failure.
Renal and haematological systems should be monitored during prolonged and high dose therapy.
Care should be taken when treating patients with syphilis, as the Jarisch-Herxheimer reaction may occur shortly after starting treatment. This reaction, manifesting as fever, chills, headache and reactions at the site of the lesion, can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.
Haemolytic anaemia and leucopenia, prolongation of bleeding time and defective platelet function have been observed. Convulsions and other signs of toxicity to the CNS may occur particularly in patients with renal failure.
Disturbances of blood electrolytes may follow the administrations of large doses of this medicine.
High doses should be used with caution in patients receiving potassium containing medicines or potassium-sparing diuretics.
Pencillin 625 contraindications
Pencillin 625 should not be given to patients known to be allergic to penicillin and should be given with care to patients with a history of allergy to cephalosporins. Cases of cross sensitivity have been reported. It should not be given to babies, in the neonatal period, born of hypersensitive mothers. It is not recommended for chronic, severe or deep-seated infections such as subacute bacterial endocarditis, meningitis or syphilis.
Active ingredient matches for Pencillin 625:
List of Pencillin 625 substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Pencillin-v500000iu | |
Pencin-V (Bangladesh) | |
Pener (Myanmar, Thailand) | |
Pener V2 200000 u x 1, 000's (Unison) | |
Pener V2 200000 u x 60 mL (Unison) | |
Pener V4 400000 u x 1, 000's (Unison) | |
Penfantil (Argentina) | |
Penhexal (Australia, Germany, Luxembourg) | |
Capsule; Oral; Penicillin V Potassium 250 mg (Hexal) | |
Capsule; Oral; Penicillin V Potassium 500 mg (Hexal) | |
Peni Oral (Belgium, Luxembourg) | |
Peni Oral 1000000UI (Luxembourg) | |
Peni-Oral (Belgium) | |
Peni-V (Tunisia) | |
Penicilina Fenoximetil Mintlab (Chile) | |
Penicilina Lepetit (Argentina) | |
Penicilina Oral Lepetit (Argentina) | |
Penicilina Oral Richet (Argentina) | |
Penicilina Richet (Argentina) | |
PenicilinĂ£ V (Romania) | |
Tablet; Oral; Penicillin V Potassium 1, 000, 000 IU | |
Penicilina V Potasica Farmatech (Colombia) | |
Penicilina V Sandoz (Argentina) | |
Penicillin Sandoz (Germany) | |
Penicillin Spirig (Switzerland) | |
Penicillin Spirig HC (Switzerland) | |
Penicillin V AbZ (Germany) | |
Penicillin V acis (Germany) | |
Penicillin V AL (Germany) | |
Penicillin V Asian Union (Thailand) | |
Penicillin V Asian Union 250 mg x 500's | |
Penicillin V Asian Union 250 mg x 1, 000's | |
Penicillin V Athlone (Hong Kong) | |
Penicillin V Athlone 125 mg/5 mL x 100 mL (Athlone) | |
Penicillin V Athlone elixir 125 mg/5 mL 100 mL x 1's (Athlone) | |
Penicillin V Athlone tab 250 mg 1000's (Athlone) | |
Penicillin V Billix (Germany) | |
Penicillin V CCPC (Taiwan) | |
Penicillin V dura (Germany) | |
Penicillin V Heumann (Germany) | |
Penicillin V Osoth (Thailand) | |
Penicillin V Osoth 400000 IU x 1, 000's | |
Penicillin V Osoth 200000 IU x 500's | |
Penicillin V Osoth 400000 IU x 500's | |
Penicillin V Osoth 200000 IU/5 mL x 60 mL | |
Penicillin V Potassium - Sandoz (China) | |
Penicillin V Stada (Germany) | |
Penicillin V-CT (Germany) | |
See 330 substitutes for Pencillin 625 |
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Information checked by Dr. Sachin Kumar, MD Pharmacology